U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MOBP myelin associated oligodendrocyte basic protein [ Homo sapiens (human) ]

    Gene ID: 4336, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MOBPprovided by HGNC
    Official Full Name
    myelin associated oligodendrocyte basic proteinprovided by HGNC
    Primary source
    HGNC:HGNC:7189
    See related
    Ensembl:ENSG00000168314 MIM:600948; AllianceGenome:HGNC:7189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion and perinuclear region of cytoplasm. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward brain (RPKM 31.3) See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MOBP in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (39467680..39529497)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (39480633..39542424)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39509171..39570988)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986075 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14229 Neighboring gene ribosomal protein SA Neighboring gene NANOG hESC enhancer GRCh37_chr3:39508789-39509471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:39513805-39514612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:39514613-39515420 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:39547383-39547882 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:39618867-39619806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:39624719-39625251 Neighboring gene NFE2L2 motif-containing MPRA enhancer 66 Neighboring gene NFU1 iron-sulfur cluster scaffold pseudogene 1 Neighboring gene MPRA-validated peak4615 silencer Neighboring gene uncharacterized LOC105377039

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Myelin-associated oligodendrocyte basic protein rs616147 polymorphism as a risk factor for Parkinson's disease. Siokas V, et al. Acta Neurol Scand, 2022 Feb. PMID 34694630
    2. MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study. Liampas I, et al. Medicina (Kaunas), 2021 Dec 7. PMID 34946282, Free PMC Article
    3. Immunoreactivity of myelin-associated oligodendrocytic basic protein in Lewy bodies. Kon T, et al. Neuropathology, 2019 Aug. PMID 31183926
    4. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. Yamamoto Y, et al. J Biol Chem, 1994 Dec 16. PMID 7989345
    5. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Irwin DJ, et al. Neurology, 2014 Aug 5. PMID 24994843, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOBP and HIP1 in multiple system atrophy: New alpha-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
      Title: MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
    2. Myelin-associated oligodendrocyte basic protein rs616147 polymorphism as a risk factor for Parkinson's disease.
      Title: Myelin-associated oligodendrocyte basic protein rs616147 polymorphism as a risk factor for Parkinson's disease.
    3. MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study.
      Title: MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study.
    4. Dentate gyrus volume deficit in schizophrenia.
      Title: Dentate gyrus volume deficit in schizophrenia.
    5. White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy.
      Title: White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy.
    6. Study shoes that myelin-associated oligodendrocytic basic protein immunoreactivity is present in the core of Lewy bodies in Parkinson's disease and dementia with Lewy Bodies.
      Title: Immunoreactivity of myelin-associated oligodendrocytic basic protein in Lewy bodies.
    7. Mutation in MOBP gene is associated with amyotrophic lateral sclerosis.
      Title: Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.
    8. rs1768208 is associated with corticobasal degeneration.
      Title: Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
    9. The rs1768208 risk polymorphism in MOBP has prognostic value in behavioral-variant frontotemporal dementia.
      Title: Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.
    10. Genotypes at MOBP and EIF2AK3 confer risk predominantly in APOE epsilon4-positive subjects, with indications of an interaction between APOE and MOBP or EIF2AK3 on Alzheimer's disease risk.
      Title: An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog
    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
    EBI GWAS Catalog
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Potential readthrough

    Included gene: RPSA

    Homology

    Clone Names

    • FLJ37799, MGC87379

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of myelin sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system myelin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    myelin-associated oligodendrocyte basic protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278322.2 → NP_001265251.1  myelin-associated oligodendrocyte basic protein isoform a

      See identical proteins and their annotated locations for NP_001265251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC092058, AK127034, DA343382
      Consensus CDS
      CCDS63598.1
      UniProtKB/Swiss-Prot
      Q13875
      Related
      ENSP00000312293.6, ENST00000311042.10
      Conserved Domains (1) summary
      cl22851
      Location:1 → 68
      PHD_SF; PHD finger superfamily

    2. NM_001278323.2 → NP_001265252.1  myelin-associated oligodendrocyte basic protein isoform b

      See identical proteins and their annotated locations for NP_001265252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BF511176, DA217942
      Consensus CDS
      CCDS2688.1
      UniProtKB/Swiss-Prot
      A8K2C2, G5E945, Q13874, Q13875, Q6DHZ6, Q8TBJ1
      Related
      ENSP00000506926.1, ENST00000682069.1
      Conserved Domains (2) summary
      PRK06995
      Location:70 → 163
      flhF; flagellar biosynthesis protein FlhF
      cl22851
      Location:1 → 69
      PHD_SF; PHD finger superfamily

    3. NM_001393704.1 → NP_001380633.1  myelin-associated oligodendrocyte basic protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC092058
      Consensus CDS
      CCDS2688.1
      UniProtKB/Swiss-Prot
      A8K2C2, G5E945, Q13874, Q13875, Q6DHZ6, Q8TBJ1
      Related
      ENSP00000508923.1, ENST00000684792.1
      Conserved Domains (2) summary
      PRK06995
      Location:70 → 163
      flhF; flagellar biosynthesis protein FlhF
      cl22851
      Location:1 → 69
      PHD_SF; PHD finger superfamily

    4. NM_182935.4 → NP_891980.1  myelin-associated oligodendrocyte basic protein isoform c

      See identical proteins and their annotated locations for NP_891980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC092058, DA343382
      Consensus CDS
      CCDS2687.1
      UniProtKB/TrEMBL
      A0A0S2Z3W1
      Related
      ENSP00000373261.3, ENST00000383754.7
      Conserved Domains (1) summary
      cl22851
      Location:1 → 73
      PHD_SF; PHD finger superfamily

    RNA

    1. NR_003090.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC092058, D28113, DA343382

    2. NR_103504.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site at an internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC092058, D28113, DA343382

    3. NR_103505.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses two alternate splice sites at an internal exon and differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC092058, D28113, D28114, DA343382

    4. NR_103506.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC092058, DA287397, DA343382

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      39467680..39529497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      39480633..39542424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13875.2 GenPept UniProtKB/Swiss-Prot:Q13875

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous