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    Tnn tenascin N [ Mus musculus (house mouse) ]

    Gene ID: 329278, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tnnprovided by MGI
    Official Full Name
    tenascin Nprovided by MGI
    Primary source
    MGI:MGI:2665790
    See related
    Ensembl:ENSMUSG00000026725 AllianceGenome:MGI:2665790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tnw; TN-W; tenascin-W
    Summary
    Enables identical protein binding activity and integrin binding activity. Involved in several processes, including generation of neurons; negative regulation of canonical Wnt signaling pathway; and negative regulation of osteoblast differentiation. Acts upstream of or within axonogenesis and cell-matrix adhesion. Located in several cellular components, including CA3 pyramidal cell dendrite; hippocampal mossy fiber expansion; and neuronal cell body. Part of tenascin complex. Is expressed in several structures, including cranium; dura mater; forelimb; palatal shelf; and periosteum. Orthologous to human TNN (tenascin N). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in kidney adult (RPKM 2.1), limb E14.5 (RPKM 1.9) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnn in Genome Data Viewer
    Location:
    1 H2.1; 1 69.4 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (159912599..159981242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (160085029..160153692, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930523C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E11694 Neighboring gene STARR-positive B cell enhancer ABC_E8778 Neighboring gene STARR-positive B cell enhancer ABC_E9489 Neighboring gene predicted gene, 37294 Neighboring gene RIKEN cDNA 4930562F07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162009351-162009552 Neighboring gene predicted gene, 53640 Neighboring gene STARR-seq mESC enhancer starr_02794 Neighboring gene STARR-seq mESC enhancer starr_02795 Neighboring gene STARR-seq mESC enhancer starr_02796 Neighboring gene mitochondrial ribosomal protein S14 Neighboring gene calcyclin binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables integrin binding  
    enables integrin binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis PubMed 
    involved_in cell-matrix adhesion  
    acts_upstream_of_or_within cell-matrix adhesion PubMed 
    involved_in dendrite self-avoidance PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of neuron migration PubMed 
    involved_in negative regulation of osteoblast differentiation PubMed 
    involved_in negative regulation of osteoblast proliferation PubMed 
    involved_in neuron migration PubMed 
    involved_in neuron projection extension  
    involved_in neuron projection extension PubMed 
    involved_in osteoblast development PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of sprouting angiogenesis  
    involved_in regulation of bone development PubMed 
    involved_in regulation of cell adhesion PubMed 
    involved_in regulation of cell adhesion  
    involved_in regulation of cell migration PubMed 
    involved_in regulation of cell migration  
    involved_in regulation of smooth muscle tissue development PubMed 
    Component Evidence Code Pubs
    located_in CA3 pyramidal cell dendrite PubMed 
    located_in cell surface PubMed 
    is_active_in collagen-containing extracellular matrix  
    located_in collagen-containing extracellular matrix PubMed 
    located_in collagen-containing extracellular matrix  
    located_in extracellular matrix PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in hippocampal mossy fiber expansion PubMed 
    located_in neuron projection PubMed 
    located_in neuronal cell body PubMed 
    part_of tenascin complex PubMed 
    part_of tenascin complex  

    General protein information

    Preferred Names
    tenascin-N
    Names
    TN-N
    tenasin W

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177839.3NP_808507.2  tenascin-N precursor

      See identical proteins and their annotated locations for NP_808507.2

      Status: VALIDATED

      Source sequence(s)
      AK048033, BC138335, BY722860, CD773844
      Consensus CDS
      CCDS15404.1
      UniProtKB/Swiss-Prot
      B9EHR3, Q70HX0, Q80Z71
      UniProtKB/TrEMBL
      E9Q1F6
      Related
      ENSMUSP00000039452.6, ENSMUST00000039178.12
      Conserved Domains (6) summary
      smart00060
      Location:532608
      FN3; Fibronectin type 3 domain
      cd00063
      Location:444529
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00087
      Location:13271539
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam18720
      Location:171198
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:264332
      fn3; Fibronectin type III domain
      pfam07974
      Location:236259
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      159912599..159981242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496904.2XP_006496967.1  tenascin-N isoform X1

      UniProtKB/TrEMBL
      E9Q1F6
      Conserved Domains (4) summary
      cd00087
      Location:12391451
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam07974
      Location:233259
      EGF_2; EGF-like domain
      pfam00041
      Location:264342
      fn3; Fibronectin type III domain
      pfam18720
      Location:171198
      EGF_Tenascin; Tenascin EGF domain
    2. XM_006496906.2XP_006496969.1  tenascin-N isoform X2

      UniProtKB/TrEMBL
      E9Q1F6
      Related
      ENSMUSP00000115685.2, ENSMUST00000131919.2
      Conserved Domains (4) summary
      cd00087
      Location:12391451
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam07974
      Location:233259
      EGF_2; EGF-like domain
      pfam00041
      Location:264342
      fn3; Fibronectin type III domain
      pfam18720
      Location:171198
      EGF_Tenascin; Tenascin EGF domain
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