ZNF426 zinc finger protein 426 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF426provided by HGNC
Official Full Name: zinc finger protein 426provided by HGNC
Primary source: HGNC:HGNC:20725
See related: Ensembl:ENSG00000130818 AllianceGenome:HGNC:20725
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: K-RBP
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression: Ubiquitous expression in esophagus (RPKM 5.6), ovary (RPKM 2.9) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (9523223..9538645, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (9649415..9664832, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (9633899..9649321, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that the DNA-binding activity of K-RBP plays an important role in repressing viral promoter activity.
Title: The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression.
It was found that herpesvirus 8 RTA can induce K-RBP degradation through the ubiquitin-proteasome pathway and that two regions in RTA are responsible.
Title: Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 426

Names: CTC-543D15.7; KSHV RTA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300883.3 → NP_001287812.1 zinc finger protein 426 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AB209837, AC008567, BP245135

Consensus CDS

CCDS74279.1

UniProtKB/TrEMBL

K7ER43

Related

ENSP00000468100.1, ENST00000593003.5

Conserved Domains (6) summary

smart00349
Location:4 → 60

KRAB; krueppel associated box

COG5048
Location:296 → 448

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:412 → 432

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:186 → 208

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:4 → 43

KRAB; KRAB box

pfam13465
Location:424 → 449

zf-H2C2_2; Zinc-finger double domain
NM_001318055.2 → NP_001304984.1 zinc finger protein 426 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate internal exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC008567, BC001791, BP245135

UniProtKB/Swiss-Prot

Q9BUY5

Conserved Domains (4) summary

COG5048
Location:223 → 375

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:339 → 359

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:113 → 135

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:351 → 376

zf-H2C2_2; Zinc-finger double domain
NM_001318056.2 → NP_001304985.1 zinc finger protein 426 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC008567, BC001791, BE315219, BP245135

Consensus CDS

CCDS82285.1

UniProtKB/TrEMBL

K7EME3

Related

ENSP00000466469.1, ENST00000589289.1

Conserved Domains (1) summary

smart00349
Location:42 → 98

KRAB; krueppel associated box
NM_024106.3 → NP_077011.1 zinc finger protein 426 isoform 1

See identical proteins and their annotated locations for NP_077011.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC008567, BC001791, BP245135

Consensus CDS

CCDS12215.1

UniProtKB/Swiss-Prot

B3KTL2, Q9BUY5

Related

ENSP00000253115.1, ENST00000253115.7

Conserved Domains (5) summary

smart00349
Location:42 → 98

KRAB; krueppel associated box

COG5048
Location:334 → 486

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:450 → 470

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:224 → 246

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:294 → 319

zf-H2C2_2; Zinc-finger double domain