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    sop-2 Polycomb protein sop-2;SAM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174874, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sop-2
    Official Full Name
    Polycomb protein sop-2;SAM domain-containing protein
    Primary source
    WormBase:WBGene00004945
    Locus tag
    CELE_C50E10.4
    See related
    AllianceGenome:WB:WBGene00004945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Is expressed widely. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sop-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (12339944..12344799)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene Serpentine Receptor, class E (epsilon) Neighboring gene ncRNA Neighboring gene Transcriptional regulator Neighboring gene tRNA Neighboring gene R-RAS related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2. Zhang H, et al. Dev Dyn, 2009 Mar. PMID 19235721, Free PMC Article
    2. SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2. Zhang H, et al. Nat Genet, 2004 May. PMID 15107848
    3. A unified mode of epigenetic gene silencing: RNA meets polycomb group proteins. Sun Y, et al. RNA Biol, 2005 Jan. PMID 17132931
    4. Finally, worm polycomb-like genes meet Hox regulation. Pires-daSilva A, et al. Dev Cell, 2003 Jun. PMID 12791262
    5. RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans. Zhang T, et al. Development, 2006 Mar. PMID 16501168

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polycomb-like genes in Caenorhabditis elegans, sop-2 and sor-3, regulate the formation of dopaminergic and serotonergic neurons and several other neuronal properties
      Title: Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.
    2. microRNAs may contribute to the tight restriction of egl-5 expression to particular cell lineages
      Title: Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2.
    3. These studies reveal that sop-2 integrates spatial, temporal, and sexual cues during C. elegans development.
      Title: The Caenorhabditis elegans PcG-like gene sop-2 regulates the temporal and sexual specificities of cell fates.
    4. SOP-2 binds to RNA via 3 RNA binding domains.
      Title: The C. elegans Polycomb gene SOP-2 encodes an RNA binding protein.
    5. SOR-1 and SOP-2 directly interact with each other and are colocalized in nuclear bodies
      Title: RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic mRNA processing body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Polycomb protein sop-2;SAM domain-containing protein
    NP_001254340.1
    • Confirmed by transcript evidence
    NP_001254341.1
    • Confirmed by transcript evidence
    NP_001254342.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12339944..12344799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267412.2 → NP_001254341.1  Polycomb protein sop-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3QMA2, Q965H3
      Conserved Domains (1) summary
      PRK11633
      Location:496 → 615
      PRK11633; cell division protein DedD; Provisional

    2. NM_001267411.2 → NP_001254340.1  Polycomb protein sop-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8P172
      Conserved Domains (1) summary
      PHA03247
      Location:366 → 621
      PHA03247; large tegument protein UL36; Provisional

    3. NM_001267413.3 → NP_001254342.1  SAM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8P173
      Conserved Domains (1) summary
      pfam05843
      Location:272 → 427
      Suf; Suppressor of forked protein (Suf)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q965H3.2

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