cars2 cysteinyl-tRNA synthetase 2, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cars2provided by ZNC
Official Full Name: cysteinyl-tRNA synthetase 2, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5564
See related: Ensembl:ENSDARG00000078546 AllianceGenome:ZFIN:ZDB-GENE-030131-5564
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi04c12; wu:fi04c12; si:ch211-198k9.5
Summary: Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Acts upstream of or within gonadotrophin-releasing hormone neuronal migration to the hypothalamus. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in cerebellum and epiphysis. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (29183959..29202797)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (28376158..28398850)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cysteinyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cysteinyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain