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    arhgef7a Rho guanine nucleotide exchange factor (GEF) 7a [ Danio rerio (zebrafish) ]

    Gene ID: 553493, updated on 28-Oct-2024

    Summary

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    Official Symbol
    arhgef7aprovided by ZNC
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 7aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060322-11
    See related
    Ensembl:ENSDARG00000006299 AllianceGenome:ZFIN:ZDB-GENE-060322-11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc28d09; wu:fc28d09
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm and lamellipodium. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See arhgef7a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21535885..21567083)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21724392..21756214)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 8 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene uncharacterized LOC110438834 Neighboring gene uncharacterized LOC108191313 Neighboring gene SRY-box transcription factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
    2. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. Tsai HY, et al. BMC Genomics, 2015 Nov 18. PMID 26582102, Free PMC Article
    3. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. Tay HG, et al. PLoS One, 2010 Apr 12. PMID 20405038, Free PMC Article
    4. Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Okuda Y, et al. Dev Dyn, 2006 Mar. PMID 16408288
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 7a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123235.1 → NP_001116707.1  rho guanine nucleotide exchange factor 7a

      Status: PROVISIONAL

      Source sequence(s)
      BX649266
      UniProtKB/TrEMBL
      A0A8N1Z0S2, B0S771
      Related
      ENSDARP00000121774.1, ENSDART00000141408.3
      Conserved Domains (8) summary
      cd12060
      Location:164 → 220
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00014
      Location:3 → 105
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00160
      Location:250 → 427
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:458 → 556
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:476 → 556
      PH; PH domain
      pfam16523
      Location:769 → 855
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:604 → 709
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:115 → 162
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      21535885..21567083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478663.2 → XP_021334338.1  rho guanine nucleotide exchange factor 7a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4K4
      Conserved Domains (7) summary
      cd12060
      Location:170 → 226
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:21 → 106
      CH; Calponin homology domain
      cd00160
      Location:256 → 433
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:464 → 562
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:775 → 861
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:621 → 715
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:116 → 168
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    2. XM_005167563.5 → XP_005167620.1  rho guanine nucleotide exchange factor 7a isoform X3

      UniProtKB/TrEMBL
      A0A8M2BF23
      Conserved Domains (8) summary
      cd12060
      Location:170 → 226
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:21 → 106
      CH; Calponin homology domain
      cd00160
      Location:256 → 433
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:464 → 562
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:482 → 562
      PH; PH domain
      pfam16523
      Location:718 → 804
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:610 → 715
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:116 → 168
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    3. XM_021478664.2 → XP_021334339.1  rho guanine nucleotide exchange factor 7a isoform X2

      UniProtKB/TrEMBL
      A0A2R8Q515, A0A8M9QAP8
      Related
      ENSDARP00000147946.1, ENSDART00000182266.1
      Conserved Domains (7) summary
      cd12060
      Location:165 → 221
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:21 → 106
      CH; Calponin homology domain
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16523
      Location:770 → 856
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:616 → 710
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:116 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    4. XM_005167564.5 → XP_005167621.1  rho guanine nucleotide exchange factor 7a isoform X4

      UniProtKB/TrEMBL
      A0A8M2BEZ3
      Conserved Domains (8) summary
      cd12060
      Location:165 → 221
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      smart00033
      Location:21 → 106
      CH; Calponin homology domain
      cd00160
      Location:251 → 428
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:459 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:477 → 557
      PH; PH domain
      pfam16523
      Location:713 → 799
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:605 → 710
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:116 → 163
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394750.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      95830..125943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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