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    ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 503714, updated on 25-Apr-2024

    Summary

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    Official Symbol
    ndufaf1provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase complex assembly factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050306-9
    See related
    Ensembl:ENSDARG00000025549 AllianceGenome:ZFIN:ZDB-GENE-050306-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk33c03; wu:fk33c03; zgc:113197
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 11. Orthologous to human NDUFAF1 (NADH:ubiquinone oxidoreductase complex assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See ndufaf1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (33246175..33251767)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (33115701..33121314)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene golgin A5 Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene opa interacting protein 5 Neighboring gene oip5 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Positive correlation between gene coexpression and positional clustering in the zebrafish genome. Ng YK, et al. BMC Genomics, 2009 Jan 22. PMID 19159490, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complex I intermediate-associated protein 30, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
    NADH dehydrogenase (ubiquinone) complex I, assembly factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013308.2 → NP_001013326.1  complex I intermediate-associated protein 30, mitochondrial

      See identical proteins and their annotated locations for NP_001013326.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090683
      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Related
      ENSDARP00000118047.1, ENSDART00000144379.3
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      33246175..33251767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156831.4 → XP_005156888.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005156888.1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    2. XM_005156829.4 → XP_005156886.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005156886.1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    3. XM_005156830.4 → XP_005156887.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005156887.1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Related
      ENSDARP00000034283.8, ENSDART00000035940.8
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    4. XM_005156832.4 → XP_005156889.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005156889.1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    5. XM_009307315.3 → XP_009305590.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_009305590.1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    6. XM_017358738.2 → XP_017214227.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)

    7. XM_005156828.4 → XP_005156885.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005156885.1

      UniProtKB/TrEMBL
      A0A8M2B3R5, F6P7F5, Q5CZW0
      Related
      ENSDARP00000121771.1, ENSDART00000136356.3
      Conserved Domains (1) summary
      pfam08547
      Location:107 → 280
      CIA30; Complex I intermediate-associated protein 30 (CIA30)
    Nucleotide Protein Strain
    Heading Accession and Version

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