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    ACOT11 acyl-CoA thioesterase 11 [ Homo sapiens (human) ]

    Gene ID: 26027, updated on 2-Nov-2024

    Summary

    Official Symbol
    ACOT11provided by HGNC
    Official Full Name
    acyl-CoA thioesterase 11provided by HGNC
    Primary source
    HGNC:HGNC:18156
    See related
    Ensembl:ENSG00000162390 MIM:606803; AllianceGenome:HGNC:18156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BFIT; THEA; THEM1; STARD14
    Summary
    This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in kidney (RPKM 35.3), small intestine (RPKM 20.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See ACOT11 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54548228..54639192)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54431560..54519420)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55013901..55104865)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2784 Neighboring gene MPRA-validated peak241 silencer Neighboring gene transaldolase 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 920 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 63 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55035141-55035653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55037069-55037592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55037593-55038114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55044894-55045404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55045405-55045913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55059979-55060801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1065 Neighboring gene family with sequence similarity 151 member A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:55102633-55103264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55106005-55106518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55106519-55107031 Neighboring gene MPRA-validated peak242 silencer Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene maestro heat like repeat family member 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55145240-55146100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55163752-55164252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55164253-55164753 Neighboring gene MPRA-validated peak243 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55181271-55181772 Neighboring gene tetratricopeptide repeat domain 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: MROH7

    Clone Names

    • KIAA0707, DKFZp667O1916

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in response to cold PubMed 
    involved_in response to temperature stimulus  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in extracellular exosome PubMed 
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix  

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 11
    Names
    START domain containing 14
    StAR-related lipid transfer (START) domain containing 14
    acyl-CoA thioester hydrolase 11
    adipose-associated thioesterase
    brown fat-inducible thioesterase
    palmitoyl-coenzyme A thioesterase
    thioesterase superfamily member 1
    thioesterase, adipose associated
    NP_056362.1
    NP_671517.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015547.4NP_056362.1  acyl-coenzyme A thioesterase 11 isoform 1

      See identical proteins and their annotated locations for NP_056362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (BFIT1) of this protein.
      Source sequence(s)
      AF416921, AL590093, DA121227
      Consensus CDS
      CCDS592.1
      UniProtKB/Swiss-Prot
      B1AQ22, D3DQ50, O75187, Q52LP1, Q53ER9, Q8WXI4, Q96DI1, Q9H883
      Related
      ENSP00000360366.3, ENST00000371316.3
      Conserved Domains (2) summary
      cd08913
      Location:344583
      START_STARD14-like; Lipid-binding START domain of mammalian STARDT14 and related proteins
      cd03442
      Location:213336
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    2. NM_147161.4NP_671517.1  acyl-coenzyme A thioesterase 11 isoform 2

      See identical proteins and their annotated locations for NP_671517.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate exons in the 3' coding region and UTR, compared to variant 1. The encoded isoform (BFIT2) has a distinct C-terminus compared to isoform BFIT1.
      Source sequence(s)
      AK023937, AL590093
      Consensus CDS
      CCDS593.1
      UniProtKB/Swiss-Prot
      Q8WXI4
      Related
      ENSP00000340260.2, ENST00000343744.7
      Conserved Domains (2) summary
      cd08913
      Location:344583
      START_STARD14-like; Lipid-binding START domain of mammalian STARDT14 and related proteins
      cd03442
      Location:213336
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      54548228..54639192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      54431560..54519420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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