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    fli1 Fli-1 proto-oncogene, ETS transcription factor [ Danio rerio (zebrafish) ]

    Gene ID: 30619, updated on 12-Oct-2024

    Summary

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    Official Symbol
    fli1provided by ZNC
    Official Full Name
    Fli-1 proto-oncogene, ETS transcription factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-426
    See related
    Ensembl:ENSDARG00000054632 AllianceGenome:ZFIN:ZDB-GENE-980526-426
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fli; cb855; fli-1; fli1a; wu:fc45b11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis and positive regulation of DNA-binding transcription factor activity. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hematopoietic system; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See fli1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (48421158..48487875)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (48426169..48493178)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene somatolactin alpha Neighboring gene v-ets avian erythroblastosis virus E26 oncogene homolog 1 Neighboring gene potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 6 Neighboring gene potassium inwardly rectifying channel subfamily J member 1a, tandem duplicate 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish. Noishiki C, et al. Angiogenesis, 2019 May. PMID 30607697
    2. Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. Al-Olabi L, et al. J Clin Invest, 2018 Apr 2. PMID 29461977, Free PMC Article
    3. Cellular resolution multiplexed FLIM tomography with dual-color Bessel beam. Xu D, et al. Biomed Opt Express, 2017 Feb 1. PMID 28270968, Free PMC Article
    4. Sequential assessment via daphnia and zebrafish for systematic toxicity screening of heterogeneous substances. Jang GH, et al. Environ Pollut, 2016 Sep. PMID 27288628
    5. Notch signaling regulates venous arterialization during zebrafish fin regeneration. Kametani Y, et al. Genes Cells, 2015 May. PMID 25810153, Free PMC Article

    See all (327) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish.
      Title: Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish.
    2. mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 expression) in zebrafish embryos.
      Title: Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1.
    3. Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
      Title: Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
    4. These results showed that young thrombocytes have higher GATA1 promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
      Title: Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation.
    5. Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
      Title: Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
    6. fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin
      Title: Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Friend leukemia integration 1 transcription factor
    Names
    Fli-1 proto-oncogene, ETS transcription factor a
    friend leukemia integration 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131348.2 → NP_571423.1  Friend leukemia integration 1 transcription factor

      See identical proteins and their annotated locations for NP_571423.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066571
      UniProtKB/TrEMBL
      Q1LUW6, Q9PU61
      Related
      ENSDARP00000071331.4, ENSDART00000076861.6
      Conserved Domains (2) summary
      cd08541
      Location:113 → 203
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:279 → 362
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      48421158..48487875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467581.2 → XP_021323256.1  Friend leukemia integration 1 transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A8M9PLW9
      Conserved Domains (2) summary
      cd08541
      Location:131 → 226
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:302 → 385
      ETS; erythroblast transformation specific domain

    2. XM_021467582.2 → XP_021323257.1  Friend leukemia integration 1 transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A8M9P0Y3
      Conserved Domains (2) summary
      cd08541
      Location:131 → 221
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:297 → 380
      ETS; erythroblast transformation specific domain

    3. XM_021467583.2 → XP_021323258.1  Friend leukemia integration 1 transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A8M9P9W7
      Conserved Domains (2) summary
      cd08541
      Location:122 → 217
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:293 → 376
      ETS; erythroblast transformation specific domain

    4. XM_005159278.5 → XP_005159335.1  Friend leukemia integration 1 transcription factor isoform X4

      UniProtKB/TrEMBL
      A0A2R8QGN6, A0A8M2B691
      Related
      ENSDARP00000151205.1, ENSDART00000184233.1
      Conserved Domains (2) summary
      cd08541
      Location:122 → 212
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:288 → 371
      ETS; erythroblast transformation specific domain

    5. XM_068214720.1 → XP_068070821.1  Friend leukemia integration 1 transcription factor isoform X1

    6. XM_068214722.1 → XP_068070823.1  Friend leukemia integration 1 transcription factor isoform X3

    7. XM_021467584.2 → XP_021323259.1  Friend leukemia integration 1 transcription factor isoform X5

      UniProtKB/TrEMBL
      A0A8M9PF94
      Conserved Domains (2) summary
      cd08541
      Location:113 → 208
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      smart00413
      Location:284 → 367
      ETS; erythroblast transformation specific domain
    Nucleotide Protein
    Heading Accession and Version

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