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    TNPO3 transportin 3 [ Homo sapiens (human) ]

    Gene ID: 23534, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TNPO3provided by HGNC
    Official Full Name
    transportin 3provided by HGNC
    Primary source
    HGNC:HGNC:17103
    See related
    Ensembl:ENSG00000064419 MIM:610032; AllianceGenome:HGNC:17103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IPO12; TRNSR; LGMD1F; LGMDD2; MTR10A; TRN-SR; TRN-SR2
    Summary
    The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]
    Expression
    Ubiquitous expression in testis (RPKM 16.7), thyroid (RPKM 13.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNPO3 in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (128954185..129056193, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130267070..130368954, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128594239..128695165, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene filamin C pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128569307-128569807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18620 Neighboring gene Sharpr-MPRA regulatory region 2205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128578271-128578854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26613 Neighboring gene interferon regulatory factor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26615 Neighboring gene RNA, 7SL, cytoplasmic 306, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr7:128622104-128622662 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128669474-128669974 Neighboring gene ornithine decarboxylase pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26616 Neighboring gene Sharpr-MPRA regulatory region 4017 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97561 Neighboring gene small nucleolar RNA U13 Neighboring gene triosephosphate isomerase 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26618 Neighboring gene zinc finger protein 195-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Next-generation sequencing identifies transportin 3 as the causative gene for LGMD1F. Torella A, et al. PLoS One, 2013. PMID 23667635, Free PMC Article
    2. Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import. Cribier A, et al. Retrovirology, 2011 Dec 16. PMID 22176773, Free PMC Article
    3. A novel autosomal dominant limb-girdle muscular dystrophy (LGMD 1F) maps to 7q32.1-32.2. Palenzuela L, et al. Neurology, 2003 Aug 12. PMID 12913210
    4. Transportin-3 Facilitates Uncoating of Influenza A Virus. Zou J, et al. Int J Mol Sci, 2022 Apr 8. PMID 35456945, Free PMC Article
    5. CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import. Janssens J, et al. Microbiol Spectr, 2021 Oct 31. PMID 34612665, Free PMC Article

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IRF5-TNOP3 polymorphisms are associated with elite control of HIV infection: A retrospective study.
      Title: IRF5-TNOP3 polymorphisms are associated with elite control of HIV infection: A retrospective study.
    2. Transportin-3 Facilitates Uncoating of Influenza A Virus.
      Title: Transportin-3 Facilitates Uncoating of Influenza A Virus.
    3. CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import.
      Title: CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import.
    4. TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein Is Independent of the Cargo-Binding Domain.
      Title: TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein Is Independent of the Cargo-Binding Domain.
    5. An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation.
      Title: An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation.
    6. our results support a model in which miR-128 is expressed in primary HIV-1 target cells, is a type I IFN response gene, and functions as a novel antiviral defense mechanism during HIV-1 infection, partly by repressing the nuclear import factors TNPO3 and by inhibiting HIV-1 replication and viral spreading
      Title: Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA.
    7. TNPO3 mutant protein expressed in limb girdle muscular dystrophy 1F cells is the second genetic defect leading to strong HIV-1 restriction.
      Title: The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection.
    8. The crystal structure of the RSLD-TNPO3 complex revealed potential CPSF6 interaction residues, which were confirmed to mediate TNPO3 binding and CPSF6 nuclear import. Both binding and nuclear import were independent of RSLD phosphorylation, though a hyperphosphorylated mimetic mutant failed to bind TNPO3 and mislocalized to the cell cytoplasm
      Title: Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
    9. A novel pathogenic variant (Arg923AspfsTer17) in TNPO3 segregates with limb-girdle muscular dystrophy 1F in a Hungarian family.
      Title: A novel pathogenic variant in TNPO3 in a Hungarian family with limb-girdle muscular dystrophy 1F.
    10. Combining these results with small-angle X-ray scattering data for the complex of TRN-SR2 with truncated integrase, we propose a molecular model of the complex. We speculate that nuclear import of the PIC may proceed concurrently with the normal nuclear transport.
      Title: N-terminal half of transportin SR2 interacts with HIV integrase.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Autosomal dominant limb-girdle muscular dystrophy type 1F
    MedGen: C1842062 OMIM: 608423 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    EBI GWAS Catalog
    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
    EBI GWAS Catalog
    Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
    EBI GWAS Catalog
    Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
    EBI GWAS Catalog
    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    EBI GWAS Catalog
    Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
    EBI GWAS Catalog
    Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
    EBI GWAS Catalog
    Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
    EBI GWAS Catalog
    Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
    EBI GWAS Catalog
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog
    Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 LAI replication requires PSIP1 (LEDGF) and TNPO3 expression as shown through CRISPR/Cas9 genome editing in primary CD4+ T cells PubMed
    Knockdown of CPSF6, TNPO3, or NUP153 through siRNA leads to decreased CA and viral DNA nuclear entry PubMed
    shRNA knockdown of TNPO3 renders cells less permissive to HIV-1 WT; HIV-1 is enhanced by TNPO3 PubMed
    Knockdown of transportin 3 (TNPO3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of transportin 3 (TNPO3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev disrupts both IN-TNPO3 and IN-importin alpha complexes PubMed
    rev The interaction of HIV-1 Rev with RAN or NUP98 hypothetically induces the binding of Rev to transportin 3 PubMed
    capsid gag TNPO3 is an export factor for both HIV-1 CA and tRNAs from the nucleus of infected cells PubMed
    gag HIV-1 inhibition by TNPO3 knockdown and CPSF6-358 is a CA-dependent manner and cytoplasmic localization of CPSF6-358 is required to inhibit HIV-1 PubMed
    gag TNPO3 directly interacts with in vitro-assembled HIV-1 CA-NC complexes. However, the other report that TNPO3 does not interact directly with HIV-1 CA tubes in vitro PubMed
    gag Cyclophilin A stabilizes the HIV-1 CA and antagonizes TNPO3 acceleration of uncoating in vitro PubMed
    gag HIV-1 N74D CA mutant remains partially dependent on TRN-SR2 for efficient infection when carrying the HIV envelope PubMed
    gag Residues N57, M66, Q67, K70, N74, and T107 in the N-terminal domain of HIV-1 CA are important for the binding to CPSF6. Mutations on these residues lead to the loss or reduction of dependency on TNPO3 and RanBP2 PubMed
    gag HIV-1 replication is dependent on TNPO3 expression and HIV-1 CA is the primary determinant for HIV-1 dependence upon TNPO3 PubMed
    gag Replacing HIV-1 CA with the corresponding MLV CA strikingly induce the chimera viruses insensitive to TNPO3 knockdown, suggesting that CA is a dominant viral determinant of TNPO3 dependency during HIV-1 infection PubMed
    gag HIV-1 CA and viral tRNAs bind to TNPO3 with greater affinity in the presence of RanGTP. The last 98 residues (amino acids 826-923) are important for CA and tRNA binding PubMed
    gag RanGTP inhibits the ability of TNPO3 to stimulate the uncoating of HIV-1 CA cores PubMed
    gag HIV-1 CA mutant with five amino acid substitutions (Q67H, K70R, H87P, T107N, and L111I) confers TNPO3-independence PubMed
    integrase gag-pol HIV-1 IN mutant R263A/K264A significantly reduces its ability of binding to TRN-SR2 and displays a block in nuclear import and integration PubMed
    gag-pol Site specific mutagenesis reveals that residues 185FKRK188 in the catalytic core domain (CCD) and 262RRK264 and K266/R269 in the C-terminal domain (CTD) in HIV-1 IN are important for its binding to TRN-SR2 PubMed
    gag-pol HIV-1 IN (amino acids 62-176) interacts with TRN-SR2 (amino acids 62-334) in yeast two-hybrid screen. TRN-SR2 imports the preintegration complex into the nucleus and TRN-SR2 knockdown inhibits early steps of HIV-1 replication PubMed
    gag-pol The binding between HIV-1 IN and TNPO3 is inhibited by RanGTP in a dose-dependent manner, leading to a TNPO3-RanGTP complex formation PubMed
    gag-pol R400E/R402E and Q761E/R762E substitutions in TNPO3 significantly impair its binding to HIV-1 IN. However, E304R and E391R/E392R have very little effect on the IN-TNPO3 interaction PubMed
    gag-pol Peptides (amino acids 170-191, 214-229, and 262-274) derived the C-terminal domain of HIV-1 IN bind to TRN-SR2 PubMed
    gag-pol HIV-1 Rev disrupts both IN-TNPO3 and IN-importin alpha complexes PubMed
    nucleocapsid gag TNPO3 directly interacts with in vitro-assembled HIV-1 CA-NC complexes PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear import signal receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in annulate lamellae IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transportin-3
    Names
    imp12
    importin 12
    limb girdle muscular dystrophy 1F (autosomal dominant)
    transportin-SR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023428.1 RefSeqGene

      Range
      5063..105989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191028.3 → NP_001177957.2  transportin-3 isoform 2

      See identical proteins and their annotated locations for NP_001177957.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC018639, AC025594
      Consensus CDS
      CCDS55162.1
      UniProtKB/TrEMBL
      B2R6H7
      Related
      ENSP00000418646.1, ENST00000471234.5
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:120 → 248
      Xpo1; Exportin 1-like protein

    2. NM_001382216.1 → NP_001369145.1  transportin-3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AC018639, AC025594
      Consensus CDS
      CCDS94196.1
      UniProtKB/TrEMBL
      B2R6H7, C9J7E5
      Related
      ENSP00000487231.1, ENST00000627585.2
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    3. NM_001382217.1 → NP_001369146.1  transportin-3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:161 → 275
      Xpo1; Exportin 1-like protein

    4. NM_001382218.1 → NP_001369147.1  transportin-3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    5. NM_001382219.1 → NP_001369148.1  transportin-3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    6. NM_001382220.1 → NP_001369149.1  transportin-3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    7. NM_001382221.1 → NP_001369150.1  transportin-3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7

    8. NM_001382222.1 → NP_001369151.1  transportin-3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    9. NM_001382223.1 → NP_001369152.1  transportin-3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594
      UniProtKB/TrEMBL
      B2R6H7
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    10. NM_012470.4 → NP_036602.1  transportin-3 isoform 1

      See identical proteins and their annotated locations for NP_036602.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC018639, AC025594
      Consensus CDS
      CCDS5809.1
      UniProtKB/Swiss-Prot
      A4D1K9, C9IZM0, Q6NUM1, Q96G71, Q96GU9, Q9Y3R2, Q9Y5L0
      UniProtKB/TrEMBL
      B2R6H7
      Related
      ENSP00000265388.5, ENST00000265388.10
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:121 → 248
      Xpo1; Exportin 1-like protein

    RNA

    1. NR_034053.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1, that causes a frameshift. An in-frame downstream translational start site is available, but it is probably not used due to an upstream ORF (uORF) with a strong Kozak consensus sequence, as well as two uORFs that overlap the putative downstream start site.
      Source sequence(s)
      AC018639, AC025594

    2. NR_167911.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    3. NR_167912.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    4. NR_167913.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    5. NR_167914.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    6. NR_167915.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    7. NR_167916.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    8. NR_167917.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    9. NR_167918.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    10. NR_167919.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    11. NR_167920.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    12. NR_167921.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    13. NR_167922.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    14. NR_167923.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    15. NR_167924.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    16. NR_167925.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    17. NR_167926.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    18. NR_167927.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018639, AC025594

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      128954185..129056193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420091.1 → XP_047276047.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      E9PFH4
      Related
      ENSP00000420089.1, ENST00000482320.5

    2. XM_047420092.1 → XP_047276048.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      E9PFH4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      130267070..130368954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357714.1 → XP_054213689.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      E9PFH4

    2. XM_054357715.1 → XP_054213690.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      E9PFH4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5L0.3 GenPept UniProtKB/Swiss-Prot:Q9Y5L0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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