LGR6 leucine rich repeat containing G protein-coupled receptor 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGR6provided by HGNC
Official Full Name: leucine rich repeat containing G protein-coupled receptor 6provided by HGNC
Primary source: HGNC:HGNC:19719
See related: Ensembl:ENSG00000133067 MIM:606653; AllianceGenome:HGNC:19719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPCR; VTS20631
Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression: Broad expression in gall bladder (RPKM 3.1), testis (RPKM 2.2) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (202193799..202319761)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (201451367..201581866)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (202162927..202288889)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The oncogenic role of LGR6 overexpression induced by aberrant Wnt/beta-catenin signaling in lung cancer.
Title: The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β-catenin signaling in lung cancer.
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study.
Title: DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study.
WNT enhancing signals in pancreatic cancer are transmitted by LGR6.
Title: WNT enhancing signals in pancreatic cancer are transmitted by LGR6.
Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases.
Title: Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases.
LGR6 activates the Wnt/beta-catenin signaling pathway and forms a beta-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells.
Title: LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells.
[Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia].
Title: [Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia].
LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.
Title: LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.
Epithelial stem cell marker LGR6 expression identifies a low-risk subgroup in human papillomavirus positive oropharyngeal squamous cell carcinoma.
Title: Epithelial stem cell marker LGR6 expression identifies a low-risk subgroup in human papillomavirus positive oropharyngeal squamous cell carcinoma.
WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.
Title: WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.
LGR6 has a role in stimulating maresin 1's key proresolving functions of phagocytes
Title: Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human leucine-rich repeat containing G protein-coupled receptor 6 (LGR6) at amino acid residues 202-203 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH64613 (e-PCR)
- UniSTS:42050

SHGC-79247 (e-PCR)
- UniSTS:102777

D1S1727 (e-PCR)
- UniSTS:2971

RH102679 (e-PCR)
- UniSTS:97013

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 6

Names: gonadotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017403.2 → NP_001017403.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform 1 precursor

See identical proteins and their annotated locations for NP_001017403.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB049405, AF088074, AL356953, BC047905, BM699180

Consensus CDS

CCDS30971.1

UniProtKB/Swiss-Prot

Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7, Q9HBX8

Related

ENSP00000356247.3, ENST00000367278.8

Conserved Domains (5) summary

smart00013
Location:34 → 68

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:131 → 392

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:330 → 344

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:70 → 91

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:375 → 434

LRR_8; Leucine rich repeat
NM_001017404.2 → NP_001017404.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3

See identical proteins and their annotated locations for NP_001017404.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AF088074, AF190501, AL356953, BC047905

Consensus CDS

CCDS30972.1

UniProtKB/Swiss-Prot

Q9HBX8

Related

ENSP00000387869.2, ENST00000439764.2

Conserved Domains (5) summary

cd00116
Location:29 → 253

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:285 → 298

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:29 → 48

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:235 → 276

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:49 → 107

LRR_8; Leucine rich repeat
NM_021636.3 → NP_067649.2 leucine-rich repeat-containing G-protein coupled receptor 6 isoform 2

See identical proteins and their annotated locations for NP_067649.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AF088074, AL356953, AY358119, BC047905

Consensus CDS

CCDS1424.1

UniProtKB/Swiss-Prot

Q9HBX8

Related

ENSP00000255432.7, ENST00000255432.11

Conserved Domains (4) summary

cd00116
Location:79 → 340

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:278 → 292

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:20 → 39

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:323 → 382

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

202193799..202319761

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047426928.1 → XP_047282884.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X4
XM_047426929.1 → XP_047282885.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X6
XM_047426931.1 → XP_047282887.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X9
XM_005245404.4 → XP_005245461.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

Conserved Domains (4) summary

cd00116
Location:88 → 349

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:287 → 301

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:29 → 48

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:332 → 391

LRR_8; Leucine rich repeat
XM_011509839.3 → XP_011508141.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3

Conserved Domains (5) summary

cd00116
Location:88 → 349

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:287 → 310

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:29 → 48

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:331 → 371

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:143 → 203

LRR_8; Leucine rich repeat
XM_017001996.2 → XP_016857485.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X5
XM_011509838.3 → XP_011508140.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X2

Conserved Domains (3) summary

cd00116
Location:186 → 375

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:29 → 48

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:308 → 367

LRR_8; Leucine rich repeat
XM_047426930.1 → XP_047282886.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X8
XM_011509840.3 → XP_011508142.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X7

Conserved Domains (5) summary

cd00116
Location:42 → 277

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:215 → 229

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:29 → 48

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:259 → 300

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:260 → 319

LRR_8; Leucine rich repeat
XM_047426932.1 → XP_047282888.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X10
XM_017001997.2 → XP_016857486.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X11
XM_011509846.3 → XP_011508148.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X13

See identical proteins and their annotated locations for XP_011508148.1

Conserved Domains (3) summary

cd00116
Location:40 → 245

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:22 → 45

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:185 → 244

LRR_8; Leucine rich repeat
XM_011509843.3 → XP_011508145.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X13

See identical proteins and their annotated locations for XP_011508145.1

Conserved Domains (3) summary

cd00116
Location:40 → 245

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:22 → 45

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:185 → 244

LRR_8; Leucine rich repeat
XM_011509841.3 → XP_011508143.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X12

Conserved Domains (5) summary

cd00116
Location:28 → 258

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:290 → 303

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:30 → 53

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:240 → 281

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:241 → 300

LRR_8; Leucine rich repeat
XM_011509842.3 → XP_011508144.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X13

See identical proteins and their annotated locations for XP_011508144.1

Conserved Domains (3) summary

cd00116
Location:40 → 245

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:22 → 45

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:185 → 244

LRR_8; Leucine rich repeat
XM_011509844.3 → XP_011508146.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X14

Conserved Domains (3) summary

cd00116
Location:10 → 183

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:116 → 175

LRR_8; Leucine rich repeat

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

201451367..201581866

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338026.1 → XP_054194001.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X4
XM_054338028.1 → XP_054194003.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X6
XM_054338031.1 → XP_054194006.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X9
XM_054338023.1 → XP_054193998.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1
XM_054338025.1 → XP_054194000.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3
XM_054338027.1 → XP_054194002.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X5
XM_054338024.1 → XP_054193999.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X2
XM_054338030.1 → XP_054194005.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X8
XM_054338029.1 → XP_054194004.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X7
XM_054338032.1 → XP_054194007.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X10
XM_054338033.1 → XP_054194008.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X11
XM_054338038.1 → XP_054194013.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X13
XM_054338035.1 → XP_054194010.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X13
XM_054338034.1 → XP_054194009.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X12
XM_054338036.1 → XP_054194011.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X13
XM_054338037.1 → XP_054194012.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform X14