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    MAP4 microtubule associated protein 4 [ Homo sapiens (human) ]

    Gene ID: 4134, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MAP4provided by HGNC
    Official Full Name
    microtubule associated protein 4provided by HGNC
    Primary source
    HGNC:HGNC:6862
    See related
    Ensembl:ENSG00000047849 MIM:157132; AllianceGenome:HGNC:6862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
    Expression
    Ubiquitous expression in heart (RPKM 53.7), brain (RPKM 28.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAP4 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (47850695..48088848, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (47878026..48116148, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47892185..48130338, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit C1 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47710070-47710273 Neighboring gene HIGD2A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14313 Neighboring gene Sharpr-MPRA regulatory region 56 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:47844773-47845298 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47846226-47846422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47859072-47859572 Neighboring gene MPRA-validated peak4635 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47879089-47879907 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47883235-47883741 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:47888661-47888762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:47893749-47894266 Neighboring gene DExH-box helicase 30 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:47912431-47912931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19820 Neighboring gene microRNA 1226 Neighboring gene MPRA-validated peak4636 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14319 Neighboring gene VPS26B pseudogene 1 Neighboring gene MPRA-validated peak4637 silencer Neighboring gene ribosomal protein S27 pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19822 Neighboring gene MPRA-validated peak4638 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48154883-48155384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48155385-48155884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48157513-48158444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48160097-48160597 Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene ribosomal protein L17 pseudogene 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs. Shigematsu H, et al. J Cell Biol, 2018 Dec 3. PMID 30275105, Free PMC Article
    2. MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and Golgi architecture as a central mechanism in growth regulation. Zahnleiter D, et al. Hum Mutat, 2015 Jan. PMID 25323976
    3. Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma. Jiang YY, et al. Oncogene, 2016 Sep 15. PMID 26876215
    4. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. Kremer BE, et al. Mol Biol Cell, 2005 Oct. PMID 16093351, Free PMC Article
    5. Truncation of the projection domain of MAP4 (microtubule-associated protein 4) leads to attenuation of microtubule dynamic instability. Permana S, et al. Cell Struct Funct, 2005 Feb. PMID 15840946

    See all (232) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism.
      Title: A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism.
    2. MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.
      Title: MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.
    3. Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
      Title: Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.
    4. Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4.
      Title: Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4.
    5. study reveals a molecular mechanism by which HPV16E7 perturbs host mitotic progression by interfering Mps1-MAP4 signaling cascade, which results in an extended infection window and may facilitate the persistent HPV16 infection
      Title: Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade.
    6. The strongest bond of MAP4 was found around the intertubulin-dimer interface such that MAP4 coexists on the microtubule with kinesin-1 bound to the intratubulin-dimer interface as well.
      Title: Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs.
    7. Further experiments revealed that MAP4 regulates microtubule dynamics and promotes epidermal cell migration through Tctex-1. MAP4 and Tctex-1 play important roles in regulating the migration of epidermal cells under hypoxia.
      Title: MAP4 regulates Tctex-1 and promotes the migration of epidermal cells in hypoxia.
    8. Results suggest that Syk, MAP4, and calpain-1 expression are correlated with each other and these proteins may be involved in early stages of tumour spread.
      Title: Expression of Syk and MAP4 proteins in ovarian cancer.
    9. Expression level of MAP4 mRNA and protein in lung adenocarcinoma tissues were significantly higher than those in noncancerous tissues. MAP4 expression significantly correlated with tumor progression.
      Title: Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.
    10. Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses.
      Title: MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of DNAL1 and MAP4 by siRNAs and shRNAs inhibits HIV-1 replication in HeLa P4.2 cells by blocking reverse transcription and 2-LTR formation PubMed
    Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated microtubule-associated protein 4 (MAP4) is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with microtubule-associated protein 4 (MAP4) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8617, DKFZp779A1753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule stabilizing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule sliding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein 4
    Names
    MAP-4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052840.1 RefSeqGene

      Range
      77864..243585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134364.2 → NP_001127836.1  microtubule-associated protein 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA904866, AB209377, DA114613
      Consensus CDS
      CCDS46818.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000379083.3, ENST00000395734.8
      Conserved Domains (1) summary
      pfam00418
      Location:992 → 1021
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    2. NM_001384675.1 → NP_001371604.1  microtubule-associated protein 4 isoform 92

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    3. NM_001384676.1 → NP_001371605.1  microtubule-associated protein 4 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:977 → 1007
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    4. NM_001384677.1 → NP_001371606.1  microtubule-associated protein 4 isoform 74

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:653 → 930
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:939 → 969
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    5. NM_001384678.1 → NP_001371607.1  microtubule-associated protein 4 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:587 → 931
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:966 → 996
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    6. NM_001384679.1 → NP_001371608.1  microtubule-associated protein 4 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:686 → 975
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:994 → 1024
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    7. NM_001384680.1 → NP_001371609.1  microtubule-associated protein 4 isoform 86

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:473 → 817
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:890 → 920
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    8. NM_001384681.1 → NP_001371610.1  microtubule-associated protein 4 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:951 → 981
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    9. NM_001384707.1 → NP_001371636.1  microtubule-associated protein 4 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 852
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:926 → 956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    10. NM_001384729.1 → NP_001371658.1  microtubule-associated protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Consensus CDS
      CCDS33750.1
      UniProtKB/Swiss-Prot
      P27816, Q13082, Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76, Q96NS9
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    11. NM_001384730.1 → NP_001371659.1  microtubule-associated protein 4 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:969 → 999
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    12. NM_001384731.1 → NP_001371660.1  microtubule-associated protein 4 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:994 → 1024
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    13. NM_001384733.1 → NP_001371662.1  microtubule-associated protein 4 isoform 81

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:653 → 905
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:929 → 959
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    14. NM_001384734.1 → NP_001371663.1  microtubule-associated protein 4 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    15. NM_001384735.1 → NP_001371664.1  microtubule-associated protein 4 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    16. NM_001384736.1 → NP_001371665.1  microtubule-associated protein 4 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:1009 → 1039
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    17. NM_001384737.1 → NP_001371666.1  microtubule-associated protein 4 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 893
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:967 → 997
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    18. NM_001384738.1 → NP_001371667.1  microtubule-associated protein 4 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:587 → 931
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:1004 → 1034
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    19. NM_001384744.1 → NP_001371673.1  microtubule-associated protein 4 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:551 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:968 → 998
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    20. NM_001384745.1 → NP_001371674.1  microtubule-associated protein 4 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:699 → 948
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:1021 → 1051
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    21. NM_001384746.1 → NP_001371675.1  microtubule-associated protein 4 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:511 → 855
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    22. NM_001384748.1 → NP_001371677.1  microtubule-associated protein 4 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:587 → 931
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:1004 → 1034
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    23. NM_001384751.1 → NP_001371680.1  microtubule-associated protein 4 isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:953 → 982
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    24. NM_001384752.1 → NP_001371681.1  microtubule-associated protein 4 isoform 106

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:575 → 852
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:721 → 995
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:882 → 912
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    25. NM_001384753.1 → NP_001371682.1  microtubule-associated protein 4 isoform 87

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:589 → 885
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:888 → 918
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    26. NM_001384754.1 → NP_001371683.1  microtubule-associated protein 4 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    27. NM_001384755.1 → NP_001371684.1  microtubule-associated protein 4 isoform 94

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    28. NM_001384756.1 → NP_001371685.1  microtubule-associated protein 4 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:977 → 1007
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    29. NM_001384757.1 → NP_001371686.1  microtubule-associated protein 4 isoform 104

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:511 → 855
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:890 → 920
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    30. NM_001384758.1 → NP_001371687.1  microtubule-associated protein 4 isoform 100

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:537 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:901 → 931
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    31. NM_001384759.1 → NP_001371688.1  microtubule-associated protein 4 isoform 112

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:612 → 864
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:873 → 903
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    32. NM_001384760.1 → NP_001371689.1  microtubule-associated protein 4 isoform 120

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:534 → 811
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:680 → 954
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:841 → 871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    33. NM_001384761.1 → NP_001371690.1  microtubule-associated protein 4 isoform 83

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:653 → 905
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:929 → 959
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    34. NM_001384762.1 → NP_001371691.1  microtubule-associated protein 4 isoform 127

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:197 → 511
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:546 → 576
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    35. NM_001384774.1 → NP_001371703.1  microtubule-associated protein 4 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:977 → 1007
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    36. NM_001384776.1 → NP_001371705.1  microtubule-associated protein 4 isoform

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:537 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:935 → 965
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    37. NM_001384777.1 → NP_001371706.1  microtubule-associated protein 4 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:969 → 999
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    38. NM_001384778.1 → NP_001371707.1  microtubule-associated protein 4 isoform 122

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:364 → 708
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:781 → 811
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    39. NM_001384779.1 → NP_001371708.1  microtubule-associated protein 4 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:679 → 917
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:920 → 950
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    40. NM_001384780.1 → NP_001371709.1  microtubule-associated protein 4 isoform 84

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:656 → 894
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:897 → 927
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    41. NM_001384781.1 → NP_001371710.1  microtubule-associated protein 4 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    42. NM_001384782.1 → NP_001371711.1  microtubule-associated protein 4 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    43. NM_001384783.1 → NP_001371712.1  microtubule-associated protein 4 isoform 80

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:630 → 907
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:931 → 961
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    44. NM_001384784.1 → NP_001371713.1  microtubule-associated protein 4 isoform 132

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:205 → 446
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:459 → 489
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    45. NM_001384785.1 → NP_001371714.1  microtubule-associated protein 4 isoform 116

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      pfam05109
      Location:665 → 980
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:867 → 897
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    46. NM_001384786.1 → NP_001371715.1  microtubule-associated protein 4 isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:931 → 961
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    47. NM_001384787.1 → NP_001371716.1  microtubule-associated protein 4 isoform 117

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:552 → 829
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:698 → 972
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:859 → 889
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    48. NM_001384788.1 → NP_001371717.1  microtubule-associated protein 4 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:1009 → 1039
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    49. NM_001384789.1 → NP_001371718.1  microtubule-associated protein 4 isoform 119

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      pfam05109
      Location:641 → 956
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:843 → 873
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    50. NM_001384790.1 → NP_001371719.1  microtubule-associated protein 4 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:971 → 1001
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    51. NM_001384791.1 → NP_001371720.1  microtubule-associated protein 4 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:551 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:968 → 998
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    52. NM_001384792.1 → NP_001371721.1  microtubule-associated protein 4 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:971 → 1001
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    53. NM_001384793.1 → NP_001371722.1  microtubule-associated protein 4 isoform 105

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:629 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:890 → 920
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    54. NM_001384794.1 → NP_001371723.1  microtubule-associated protein 4 isoform 82

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK13914
      Location:673 → 889
      PRK13914; invasion associated endopeptidase
      pfam00418
      Location:899 → 929
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    55. NM_001384795.1 → NP_001371724.1  microtubule-associated protein 4 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:604 → 948
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:93 → 260
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:1021 → 1051
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    56. NM_001384796.1 → NP_001371725.1  microtubule-associated protein 4 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:971 → 1001
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    57. NM_001384797.1 → NP_001371726.1  microtubule-associated protein 4 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:551 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:953 → 983
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    58. NM_001384798.1 → NP_001371727.1  microtubule-associated protein 4 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    59. NM_001384800.1 → NP_001371729.1  microtubule-associated protein 4 isoform 75

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:939 → 969
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    60. NM_001384802.1 → NP_001371731.1  microtubule-associated protein 4 isoform 128

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:180 → 429
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:502 → 532
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    61. NM_001384803.1 → NP_001371732.1  microtubule-associated protein 4 isoform 110

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:496 → 840
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:875 → 905
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    62. NM_001384804.1 → NP_001371733.1  microtubule-associated protein 4 isoform 73

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03307
      Location:532 → 910
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:912 → 942
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    63. NM_001384805.1 → NP_001371734.1  microtubule-associated protein 4 isoform 121

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:534 → 811
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:680 → 954
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:841 → 871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    64. NM_001384806.1 → NP_001371735.1  microtubule-associated protein 4 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    65. NM_001384807.1 → NP_001371736.1  microtubule-associated protein 4 isoform 111

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:496 → 840
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:875 → 905
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    66. NM_001384808.1 → NP_001371737.1  microtubule-associated protein 4 isoform 129

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:180 → 429
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:502 → 532
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    67. NM_001384809.1 → NP_001371738.1  microtubule-associated protein 4 isoform 108

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:575 → 852
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:721 → 995
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:882 → 912
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    68. NM_001384810.1 → NP_001371739.1  microtubule-associated protein 4 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    69. NM_001384811.1 → NP_001371740.1  microtubule-associated protein 4 isoform 118

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:552 → 829
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:698 → 972
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:859 → 889
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    70. NM_001384812.1 → NP_001371741.1  microtubule-associated protein 4 isoform 133

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:180 → 429
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:449 → 479
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    71. NM_001384813.1 → NP_001371742.1  microtubule-associated protein 4 isoform 125

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:219 → 554
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:558 → 588
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    72. NM_001384814.1 → NP_001371743.1  microtubule-associated protein 4 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    73. NM_001384815.1 → NP_001371744.1  microtubule-associated protein 4 isoform 131

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:180 → 429
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:464 → 494
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    74. NM_001384816.1 → NP_001371745.1  microtubule-associated protein 4 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:969 → 999
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    75. NM_001384817.1 → NP_001371746.1  microtubule-associated protein 4 isoform 130

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:156 → 445
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:464 → 494
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    76. NM_001384819.1 → NP_001371748.1  microtubule-associated protein 4 isoform 76

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    77. NM_001384820.1 → NP_001371749.1  microtubule-associated protein 4 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 893
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:967 → 997
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    78. NM_001384824.1 → NP_001371753.1  microtubule-associated protein 4 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:653 → 905
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:929 → 959
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    79. NM_001384825.1 → NP_001371754.1  microtubule-associated protein 4 isoform 88

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:537 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:916 → 946
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    80. NM_001384826.1 → NP_001371755.1  microtubule-associated protein 4 isoform 113

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:606 → 817
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:841 → 871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    81. NM_001384827.1 → NP_001371756.1  microtubule-associated protein 4 isoform 79

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:653 → 906
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:930 → 960
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    82. NM_001384828.1 → NP_001371757.1  microtubule-associated protein 4 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:931 → 961
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    83. NM_001384831.1 → NP_001371760.1  microtubule-associated protein 4 isoform 77

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK13914
      Location:656 → 900
      PRK13914; invasion associated endopeptidase
      pfam00418
      Location:905 → 935
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    84. NM_001384832.1 → NP_001371761.1  microtubule-associated protein 4 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:537 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    85. NM_001384834.1 → NP_001371763.1  microtubule-associated protein 4 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:545 → 889
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:962 → 992
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    86. NM_001384835.1 → NP_001371764.1  microtubule-associated protein 4 isoform 134

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:166 → 368
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:392 → 422
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    87. NM_001384836.1 → NP_001371765.1  microtubule-associated protein 4 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:951 → 981
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    88. NM_001384837.1 → NP_001371766.1  microtubule-associated protein 4 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:936 → 966
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    89. NM_001384838.1 → NP_001371767.1  microtubule-associated protein 4 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 910
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:983 → 1013
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    90. NM_001384839.1 → NP_001371768.1  microtubule-associated protein 4 isoform 89

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:468 → 812
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:885 → 915
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    91. NM_001384840.1 → NP_001371769.1  microtubule-associated protein 4 isoform 95

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:647 → 858
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:882 → 912
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    92. NM_001384841.1 → NP_001371770.1  microtubule-associated protein 4 isoform 102

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:537 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:901 → 931
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    93. NM_001384842.1 → NP_001371771.1  microtubule-associated protein 4 isoform 114

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:600 → 838
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:841 → 871
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    94. NM_001384843.1 → NP_001371772.1  microtubule-associated protein 4 isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:496 → 840
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    95. NM_001384844.1 → NP_001371773.1  microtubule-associated protein 4 isoform 109

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:575 → 852
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:721 → 995
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:882 → 912
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    96. NM_001384845.1 → NP_001371774.1  microtubule-associated protein 4 isoform 101

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:468 → 812
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:870 → 900
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    97. NM_001384846.1 → NP_001371775.1  microtubule-associated protein 4 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:939 → 969
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    98. NM_001384847.1 → NP_001371776.1  microtubule-associated protein 4 isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:679 → 917
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:920 → 950
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    99. NM_001384848.1 → NP_001371777.1  microtubule-associated protein 4 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    100. NM_001384849.1 → NP_001371778.1  microtubule-associated protein 4 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:562 → 906
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:979 → 1009
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    101. NM_001384850.1 → NP_001371779.1  microtubule-associated protein 4 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 852
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:926 → 956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    102. NM_001384851.1 → NP_001371780.1  microtubule-associated protein 4 isoform 97

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:641 → 879
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:882 → 912
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    103. NM_001384853.1 → NP_001371782.1  microtubule-associated protein 4 isoform 85

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:898 → 928
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    104. NM_001384856.1 → NP_001371785.1  microtubule-associated protein 4 isoform 124

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:364 → 708
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:743 → 773
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    105. NM_001384857.1 → NP_001371786.1  microtubule-associated protein 4 isoform 90

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:916 → 946
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    106. NM_001384859.1 → NP_001371788.1  microtubule-associated protein 4 isoform 98

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:549 → 893
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    107. NM_001384861.1 → NP_001371790.1  microtubule-associated protein 4 isoform 115

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      pfam05109
      Location:665 → 980
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:867 → 897
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    108. NM_001384862.1 → NP_001371791.1  microtubule-associated protein 4 isoform 123

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:505 → 757
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:781 → 811
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    109. NM_001384863.1 → NP_001371792.1  microtubule-associated protein 4 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:603 → 947
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:982 → 1012
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    110. NM_001384864.1 → NP_001371793.1  microtubule-associated protein 4 isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:511 → 855
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:928 → 958
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    111. NM_001384866.1 → NP_001371795.1  microtubule-associated protein 4 isoform 99

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:638 → 876
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:879 → 909
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    112. NM_001384867.1 → NP_001371796.1  microtubule-associated protein 4 isoform 91

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:468 → 812
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:885 → 915
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    113. NM_001384868.1 → NP_001371797.1  microtubule-associated protein 4 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:951 → 981
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    114. NM_001384869.1 → NP_001371798.1  microtubule-associated protein 4 isoform 78

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:552 → 896
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:931 → 961
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    115. NM_001384870.1 → NP_001371799.1  microtubule-associated protein 4 isoform 93

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:647 → 858
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:882 → 912
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    116. NM_001384871.1 → NP_001371800.1  microtubule-associated protein 4 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 894
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:968 → 998
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    117. NM_001384872.1 → NP_001371801.1  microtubule-associated protein 4 isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:665 → 942
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:951 → 981
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    118. NM_001384873.1 → NP_001371802.1  microtubule-associated protein 4 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:549 → 893
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:966 → 996
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    119. NM_001384874.1 → NP_001371803.1  microtubule-associated protein 4 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:545 → 889
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:924 → 954
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    120. NM_001384875.1 → NP_001371804.1  microtubule-associated protein 4 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:587 → 931
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:989 → 1019
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    121. NM_001384876.1 → NP_001371805.1  microtubule-associated protein 4 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:537 → 881
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    122. NM_001384877.1 → NP_001371806.1  microtubule-associated protein 4 isoform 126

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:198 → 470
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:543 → 573
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    123. NM_001384878.1 → NP_001371807.1  microtubule-associated protein 4 isoform 96

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:572 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:913 → 943
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    124. NM_001384879.1 → NP_001371808.1  microtubule-associated protein 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    125. NM_001384892.1 → NP_001371821.1  microtubule-associated protein 4 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:545 → 889
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:962 → 992
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    126. NM_001384893.1 → NP_001371822.1  microtubule-associated protein 4 isoform 103

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:534 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:898 → 928
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    127. NM_001385664.1 → NP_001372593.1  microtubule-associated protein 4 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:1775 → 2024
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:2059 → 2089
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    128. NM_001385665.1 → NP_001372594.1  microtubule-associated protein 4 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    129. NM_001385675.1 → NP_001372604.1  microtubule-associated protein 4 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (3) summary
      PHA03247
      Location:587 → 931
      PHA03247; large tegument protein UL36; Provisional
      COG3456
      Location:76 → 243
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      pfam00418
      Location:966 → 996
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    130. NM_001385676.1 → NP_001372605.1  microtubule-associated protein 4 isoform 107

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:615 → 853
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:856 → 886
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    131. NM_001385677.1 → NP_001372606.1  microtubule-associated protein 4 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:954 → 984
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    132. NM_001385681.1 → NP_001372610.1  microtubule-associated protein 4 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:971 → 1001
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    133. NM_001385682.1 → NP_001372611.1  microtubule-associated protein 4 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Consensus CDS
      CCDS93263.1
      UniProtKB/TrEMBL
      A0A804HKE7
      Related
      ENSP00000507895.1, ENST00000683076.1
      Conserved Domains (2) summary
      PHA03247
      Location:1815 → 2064
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:2137 → 2167
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    134. NM_001385684.1 → NP_001372613.1  microtubule-associated protein 4 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:939 → 969
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    135. NM_001385685.1 → NP_001372614.1  microtubule-associated protein 4 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PRK07003
      Location:679 → 917
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam00418
      Location:920 → 950
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    136. NM_001385686.1 → NP_001372615.1  microtubule-associated protein 4 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:592 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:1009 → 1039
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    137. NM_001385687.1 → NP_001372616.1  microtubule-associated protein 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:1815 → 2064
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:2137 → 2167
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    138. NM_001385688.1 → NP_001372617.1  microtubule-associated protein 4 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:1814 → 2051
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:2060 → 2090
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    139. NM_001385689.1 → NP_001372618.1  microtubule-associated protein 4 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      Conserved Domains (2) summary
      PHA03247
      Location:1815 → 2064
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:2099 → 2129
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    140. NM_001385690.1 → NP_001372619.1  microtubule-associated protein 4 isoform 135

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      UniProtKB/TrEMBL
      A0A0J9YW37

    141. NM_001385691.1 → NP_001372620.1  microtubule-associated protein 4 isoform 135

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      UniProtKB/TrEMBL
      A0A0J9YW37

    142. NM_001385692.1 → NP_001372621.1  microtubule-associated protein 4 isoform 135

      Status: REVIEWED

      Source sequence(s)
      AC124916, AC139667
      UniProtKB/TrEMBL
      A0A0J9YW37

    143. NM_002375.5 → NP_002366.2  microtubule-associated protein 4 isoform 1

      See identical proteins and their annotated locations for NP_002366.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
      Source sequence(s)
      AA904866, AB209377, DA114613, M64571
      Consensus CDS
      CCDS33750.1
      UniProtKB/Swiss-Prot
      P27816, Q13082, Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76, Q96NS9
      Related
      ENSP00000353375.6, ENST00000360240.10
      Conserved Domains (2) summary
      PHA03247
      Location:575 → 919
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:992 → 1022
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    144. NM_030885.4 → NP_112147.2  microtubule-associated protein 4 isoform 3

      See identical proteins and their annotated locations for NP_112147.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple exons in the 3' region and uses an unique splice site at the 3' end-exon compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA206810, AI078534, BC051843, DA114613, DA150735
      Consensus CDS
      CCDS46821.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000397414.1, ENST00000439356.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      47850695..48088848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448133.1 → XP_047304089.1  microtubule-associated protein 4 isoform X23

    2. XM_047448129.1 → XP_047304085.1  microtubule-associated protein 4 isoform X18

    3. XM_047448128.1 → XP_047304084.1  microtubule-associated protein 4 isoform X17

    4. XM_047448125.1 → XP_047304081.1  microtubule-associated protein 4 isoform X14

    5. XM_047448119.1 → XP_047304075.1  microtubule-associated protein 4 isoform X7

    6. XM_047448132.1 → XP_047304088.1  microtubule-associated protein 4 isoform X22

    7. XM_047448127.1 → XP_047304083.1  microtubule-associated protein 4 isoform X16

    8. XM_047448122.1 → XP_047304078.1  microtubule-associated protein 4 isoform X10

    9. XM_047448121.1 → XP_047304077.1  microtubule-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E7EVA0
      Related
      ENSP00000407602.2, ENST00000426837.6

    10. XM_047448118.1 → XP_047304074.1  microtubule-associated protein 4 isoform X3

    11. XM_047448124.1 → XP_047304080.1  microtubule-associated protein 4 isoform X13

    12. XM_017006397.2 → XP_016861886.1  microtubule-associated protein 4 isoform X21

    13. XM_047448131.1 → XP_047304087.1  microtubule-associated protein 4 isoform X20

    14. XM_047448130.1 → XP_047304086.1  microtubule-associated protein 4 isoform X19

    15. XM_047448123.1 → XP_047304079.1  microtubule-associated protein 4 isoform X12

    16. XM_011533708.3 → XP_011532010.1  microtubule-associated protein 4 isoform X11

      Conserved Domains (1) summary
      pfam00418
      Location:2134 → 2163
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    17. XM_047448126.1 → XP_047304082.1  microtubule-associated protein 4 isoform X15

    18. XM_047448120.1 → XP_047304076.1  microtubule-associated protein 4 isoform X8

    19. XM_011533705.2 → XP_011532007.1  microtubule-associated protein 4 isoform X6

      Conserved Domains (1) summary
      pfam00418
      Location:2149 → 2178
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    20. XM_017006391.2 → XP_016861880.1  microtubule-associated protein 4 isoform X5

    21. XM_011533704.3 → XP_011532006.1  microtubule-associated protein 4 isoform X4

      Conserved Domains (1) summary
      pfam00418
      Location:2151 → 2180
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    22. XM_011533703.3 → XP_011532005.1  microtubule-associated protein 4 isoform X2

      Conserved Domains (1) summary
      pfam00418
      Location:2166 → 2195
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    23. XM_024453523.2 → XP_024309291.1  microtubule-associated protein 4 isoform X1

      Conserved Domains (3) summary
      pfam00418
      Location:2197 → 2226
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93 → 260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:1844 → 2093
      Atrophin-1; Atrophin-1 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      47878026..48116148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346540.1 → XP_054202515.1  microtubule-associated protein 4 isoform X23

    2. XM_054346535.1 → XP_054202510.1  microtubule-associated protein 4 isoform X18

    3. XM_054346534.1 → XP_054202509.1  microtubule-associated protein 4 isoform X17

    4. XM_054346531.1 → XP_054202506.1  microtubule-associated protein 4 isoform X14

    5. XM_054346524.1 → XP_054202499.1  microtubule-associated protein 4 isoform X7

    6. XM_054346539.1 → XP_054202514.1  microtubule-associated protein 4 isoform X22

    7. XM_054346533.1 → XP_054202508.1  microtubule-associated protein 4 isoform X16

    8. XM_054346527.1 → XP_054202502.1  microtubule-associated protein 4 isoform X10

    9. XM_054346526.1 → XP_054202501.1  microtubule-associated protein 4 isoform X9

    10. XM_054346520.1 → XP_054202495.1  microtubule-associated protein 4 isoform X3

    11. XM_054346530.1 → XP_054202505.1  microtubule-associated protein 4 isoform X13

    12. XM_054346538.1 → XP_054202513.1  microtubule-associated protein 4 isoform X21

    13. XM_054346537.1 → XP_054202512.1  microtubule-associated protein 4 isoform X20

    14. XM_054346536.1 → XP_054202511.1  microtubule-associated protein 4 isoform X19

    15. XM_054346529.1 → XP_054202504.1  microtubule-associated protein 4 isoform X12

    16. XM_054346528.1 → XP_054202503.1  microtubule-associated protein 4 isoform X11

    17. XM_054346532.1 → XP_054202507.1  microtubule-associated protein 4 isoform X15

    18. XM_054346525.1 → XP_054202500.1  microtubule-associated protein 4 isoform X8

    19. XM_054346523.1 → XP_054202498.1  microtubule-associated protein 4 isoform X6

    20. XM_054346522.1 → XP_054202497.1  microtubule-associated protein 4 isoform X5

    21. XM_054346521.1 → XP_054202496.1  microtubule-associated protein 4 isoform X4

    22. XM_054346519.1 → XP_054202494.1  microtubule-associated protein 4 isoform X2

    23. XM_054346518.1 → XP_054202493.1  microtubule-associated protein 4 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134365.1: Suppressed sequence

      Description
      NM_001134365.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_030884.3: Suppressed sequence

      Description
      NM_030884.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27816.3 GenPept UniProtKB/Swiss-Prot:P27816

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