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    TBK1 TANK binding kinase 1 [ Homo sapiens (human) ]

    Gene ID: 29110, updated on 1-Mar-2024

    Summary

    Official Symbol
    TBK1provided by HGNC
    Official Full Name
    TANK binding kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11584
    See related
    Ensembl:ENSG00000183735 MIM:604834; AllianceGenome:HGNC:11584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAK; T2K; IIAE8; FTDALS4
    Summary
    The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in testis (RPKM 15.8), bone marrow (RPKM 10.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TBK1 in Genome Data Viewer
    Location:
    12q14.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (64452120..64502114)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (64430747..64480735)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (64845900..64895894)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6592 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:64798894-64799770 Neighboring gene ribosomal protein S11 pseudogene 6 Neighboring gene exportin for tRNA Neighboring gene MPRA-validated peak1761 silencer Neighboring gene mitochondrial ribosomal protein S25 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6593 Neighboring gene uncharacterized LOC105369803 Neighboring gene Ras association domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6594 Neighboring gene small nucleolar RNA SNORD83

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif co-immunoprecipitates with TBK1 suggesting an interaction between Vif and TBK1 PubMed
    Vpr vpr HIV-1 Vpr co-immunoprecipitates with TBK1 suggesting an interaction between Vpr and TBK1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11330

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cytoplasmic pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in dendritic cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of xenophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of serine/threonine protein kinase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase TBK1
    Names
    NF-kB-activating kinase
    NF-kappa-B-activating kinase
    NP_037386.1
    XP_005268866.1
    XP_005268867.1
    XP_054227832.1
    XP_054227833.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046906.1 RefSeqGene

      Range
      5061..55055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1306

    mRNA and Protein(s)

    1. NM_013254.4NP_037386.1  serine/threonine-protein kinase TBK1

      See identical proteins and their annotated locations for NP_037386.1

      Status: REVIEWED

      Source sequence(s)
      AA970899, AC135279, AC136977, BC034950
      Consensus CDS
      CCDS8968.1
      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
      Related
      ENSP00000329967.5, ENST00000331710.10
      Conserved Domains (3) summary
      smart00220
      Location:9242
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd12219
      Location:297385
      UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
      cd13988
      Location:15330
      STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      64452120..64502114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268810.2XP_005268867.1  serine/threonine-protein kinase TBK1 isoform X1

      See identical proteins and their annotated locations for XP_005268867.1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
      Conserved Domains (3) summary
      smart00220
      Location:9242
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd12219
      Location:297385
      UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
      cd13988
      Location:15330
      STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1
    2. XM_005268809.2XP_005268866.1  serine/threonine-protein kinase TBK1 isoform X1

      See identical proteins and their annotated locations for XP_005268866.1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
      Conserved Domains (3) summary
      smart00220
      Location:9242
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd12219
      Location:297385
      UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
      cd13988
      Location:15330
      STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1

    RNA

    1. XR_007063071.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      64430747..64480735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371858.1XP_054227833.1  serine/threonine-protein kinase TBK1 isoform X1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646
    2. XM_054371857.1XP_054227832.1  serine/threonine-protein kinase TBK1 isoform X1

      UniProtKB/Swiss-Prot
      A8K4S4, Q8IYV3, Q9NUJ5, Q9UHD2
      UniProtKB/TrEMBL
      A0A7I2V646

    RNA

    1. XR_008488571.1 RNA Sequence