lrmp lymphoid-restricted membrane protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lrmpprovided by ZNC
Official Full Name: lymphoid-restricted membrane proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-152
See related: Ensembl:ENSDARG00000045574 AllianceGenome:ZFIN:ZDB-GENE-041210-152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: irag2; fi05h08; wu:fi05h08; si:dkey-172o10.2; si:dkey-172o10.3; si:dkey-172o10.4
Summary: Involved in several processes, including mRNA transport; pronuclear fusion; and pronuclear migration. Located in several cellular components, including endoplasmic reticulum membrane; microtubule cytoskeleton; and nuclear membrane. Is expressed in blastomere and unfertilized egg. Orthologous to human IRAG2 (inositol 1,4,5-triphosphate receptor associated 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (17253421..17282531, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (17264445..17293558, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrmp's maternally inherited products are essential for nucleus-centrosome attachment and pronuclear congression during fertilization. Subcellular localization of lrmp products also suggests spatiotemporal regulation of their function in the early embryo.
Title: Localized products of futile cycle/lrmp promote centrosome-nucleus attachment in the zebrafish zygote.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pronuclear fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in pronuclear fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pronuclear migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pronuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol 1,4,5-triphosphate receptor associated 2

Names: fue; futile cycle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346283.1 → NP_001333212.1 inositol 1,4,5-triphosphate receptor associated 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

JX297440

UniProtKB/Swiss-Prot

Q5RHB5

Related

ENSDARP00000143787.2, ENSDART00000178686.2
NM_001346284.1 → NP_001333213.1 inositol 1,4,5-triphosphate receptor associated 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JX297440, JX297441

UniProtKB/Swiss-Prot

J9WMP5, Q5RHB5

Related

ENSDARP00000118448.1, ENSDART00000135730.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

17253421..17282531 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009300316.4 → XP_009298591.1 inositol 1,4,5-triphosphate receptor associated 2 isoform X2

UniProtKB/TrEMBL

A0A8M3ARP2

Conserved Domains (6) summary

pfam05781
Location:1008 → 1484

MRVI1; MRVI1 protein

pfam14658
Location:230 → 295

EF-hand_9; EF-hand domain

pfam14662
Location:347 → 538

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam14772
Location:433 → 535

NYD-SP28; Sperm tail

pfam16043
Location:356 → 472

DUF4795; Domain of unknown function (DUF4795)

cl03075
Location:637 → 833

GrpE; nucleotide exchange factor GrpE
XM_068219707.1 → XP_068075808.1 inositol 1,4,5-triphosphate receptor associated 2 isoform X5
XM_009300318.4 → XP_009298593.1 inositol 1,4,5-triphosphate receptor associated 2 isoform X4

See identical proteins and their annotated locations for XP_009298593.1

UniProtKB/Swiss-Prot

Q5RHB5

Conserved Domains (6) summary

pfam05781
Location:1012 → 1418

MRVI1; MRVI1 protein

pfam14658
Location:230 → 295

EF-hand_9; EF-hand domain

pfam14662
Location:347 → 538

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam14772
Location:433 → 535

NYD-SP28; Sperm tail

pfam16043
Location:356 → 472

DUF4795; Domain of unknown function (DUF4795)

cl03075
Location:637 → 833

GrpE; nucleotide exchange factor GrpE
XM_009300317.4 → XP_009298592.1 inositol 1,4,5-triphosphate receptor associated 2 isoform X3

See identical proteins and their annotated locations for XP_009298592.1

UniProtKB/Swiss-Prot

J9WMP5, Q5RHB5

Conserved Domains (6) summary

pfam05781
Location:1012 → 1447

MRVI1; MRVI1 protein

pfam14658
Location:230 → 295

EF-hand_9; EF-hand domain

pfam14662
Location:347 → 538

KASH_CCD; Coiled-coil region of CCDC155 or KASH

pfam14772
Location:433 → 535

NYD-SP28; Sperm tail

pfam16043
Location:356 → 472

DUF4795; Domain of unknown function (DUF4795)

cl03075
Location:637 → 833

GrpE; nucleotide exchange factor GrpE
XM_005164777.5 → XP_005164834.1 inositol 1,4,5-triphosphate receptor associated 2 isoform X1

See identical proteins and their annotated locations for XP_005164834.1

UniProtKB/TrEMBL

A0A8M9QBC0

Conserved Domains (4) summary

pfam05781
Location:1012 → 1488

MRVI1; MRVI1 protein

pfam14658
Location:230 → 295

EF-hand_9; EF-hand domain

pfam14662
Location:347 → 537

KASH_CCD; Coiled-coil region of CCDC155 or KASH

cl25732
Location:273 → 809

SMC_N; RecF/RecN/SMC N terminal domain
XM_021475075.2 → XP_021330750.1 inositol 1,4,5-triphosphate receptor associated 2 isoform X1

UniProtKB/TrEMBL

A0A8M9QBC0

Conserved Domains (4) summary

pfam05781
Location:1012 → 1488

MRVI1; MRVI1 protein

pfam14658
Location:230 → 295

EF-hand_9; EF-hand domain

pfam14662
Location:347 → 537

KASH_CCD; Coiled-coil region of CCDC155 or KASH

cl25732
Location:273 → 809

SMC_N; RecF/RecN/SMC N terminal domain