U.S. flag

An official website of the United States government

Links from Nucleotide

    • Showing Current items.

    DUSP1 dual specificity phosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 1843, updated on 5-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    DUSP1provided by HGNC
    Official Full Name
    dual specificity phosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:3064
    See related
    Ensembl:ENSG00000120129 MIM:600714; AllianceGenome:HGNC:3064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HVH1; MKP1; CL100; MKP-1; PTPN10
    Summary
    The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in gall bladder (RPKM 359.2), prostate (RPKM 315.6) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DUSP1 in Genome Data Viewer
    Location:
    5q35.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172768096..172771195, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173308211..173311310, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172195099..172198198, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene uncharacterized LOC107986479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172139792-172140399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172141615-172142220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172153656-172154156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172170835-172171336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172171337-172171836 Neighboring gene heart enhancer 25 Neighboring gene uncharacterized LOC101928093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23642 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172194940-172195132 Neighboring gene VISTA enhancer hs1828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16625 Neighboring gene uncharacterized LOC105377730 Neighboring gene cyclin Q pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172214701-172215202 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172232818-172233634 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:172233916-172235115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172246893-172247394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172250515-172251016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172251017-172251516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172262000-172262992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172262993-172263984 Neighboring gene uncharacterized LOC124901135 Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Gumpena R, et al. Acta Crystallogr F Struct Biol Commun, 2018 Sep 1. PMID 30198887, Free PMC Article
    2. DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection. Robitaille AC, et al. Sci Rep, 2017 Dec 12. PMID 29234123, Free PMC Article
    3. Corticosteroid-Induced MKP-1 Represses Pro-Inflammatory Cytokine Secretion by Enhancing Activity of Tristetraprolin (TTP) in ASM Cells. Prabhala P, et al. J Cell Physiol, 2016 Oct. PMID 26825339
    4. Angiotensin II signaling via type 2 receptors in a human model of vascular hyporeactivity: implications for hypertension. Calò LA, et al. J Hypertens, 2010 Jan. PMID 19797979
    5. Induction of MAPK phosphatase-1 by hypothermia inhibits TNF-alpha-induced endothelial barrier dysfunction and apoptosis. Yang D, et al. Cardiovasc Res, 2010 Feb 1. PMID 19793766

    See all (260) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arntl-induced upregulation of DUSP1 inhibits tumor progression in esophageal squamous cell carcinoma by inactivating ERK signaling.
      Title: Arntl-induced upregulation of DUSP1 inhibits tumor progression in esophageal squamous cell carcinoma by inactivating ERK signaling.
    2. Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation.
      Title: Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation.
    3. Upregulation of hsa-miR-141-3p promotes uterine cervical carcinoma progression via targeting dual-specificity protein phosphatase 1.
      Title: Upregulation of hsa-miR-141-3p promotes uterine cervical carcinoma progression via targeting dual-specificity protein phosphatase 1.
    4. CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth.
      Title: CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth.
    5. CSGALNACT2 restricts ovarian cancer migration and invasion by modulating MAPK/ERK pathway through DUSP1.
      Title: CSGALNACT2 restricts ovarian cancer migration and invasion by modulating MAPK/ERK pathway through DUSP1.
    6. DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression.
      Title: DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression.
    7. CIRCUSP42 AMELIORATES LPS-INDUCED HUMAN RENAL EPITHELIAL CELLS IN VITRO BY REGULATING THE MIR-182-5P/DUSP1 AXIS.
      Title: CIRCUSP42 AMELIORATES LPS-INDUCED HUMAN RENAL EPITHELIAL CELLS IN VITRO BY REGULATING THE MIR-182-5P/DUSP1 AXIS.
    8. [Hsa-miR-148a-3p promotes malignant behavior of breast cancer cells by downregulating DUSP1].
      Title: [Hsa-miR-148a-3p promotes malignant behavior of breast cancer cells by downregulating DUSP1].
    9. DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells.
      Title: DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells.
    10. Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in Airway Epithelial Cells.
      Title: Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in Airway Epithelial Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (207)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of dual specificity protein phosphatase 1 (DUSP1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef inhibits TNF-alpha release and enhances the expression of MKP-1 in human macrophages PubMed
    Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of MKP-1 PubMed
    Vif vif HIV-1 Vif upregulates the expression of dual specificity phosphatase 1 (DUSP1) in Vif-expression T cells PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables histone H2AXY142 phosphatase activity  
    enables mitogen-activated protein kinase binding  
    enables myosin phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables protein binding PubMed 
    enables protein serine/threonine phosphatase activity  
    enables protein tyrosine phosphatase activity PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent  
    enables protein tyrosine/serine/threonine phosphatase activity PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to chemokine PubMed 
    involved_in chromatin remodeling  
    involved_in endoderm formation  
    involved_in negative regulation of MAP kinase activity PubMed 
    involved_in negative regulation of MAPK cascade  
    involved_in negative regulation of cell adhesion PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of meiotic cell cycle  
    involved_in negative regulation of monocyte chemotaxis PubMed 
    involved_in negative regulation of p38MAPK cascade  
    involved_in negative regulation of p38MAPK cascade PubMed 
    involved_in peptidyl-serine dephosphorylation  
    involved_in peptidyl-threonine dephosphorylation  
    involved_in peptidyl-tyrosine dephosphorylation PubMed 
    involved_in peptidyl-tyrosine dephosphorylation  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    dual specificity protein phosphatase 1
    Names
    CL 100
    MAP kinase phosphatase 1
    dual specificity protein phosphatase hVH1
    mitogen-activated protein kinase phosphatase 1
    protein-tyrosine phosphatase CL100
    serine/threonine specific protein phosphatase
    NP_004408.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004417.4 → NP_004408.1  dual specificity protein phosphatase 1

      See identical proteins and their annotated locations for NP_004408.1

      Status: REVIEWED

      Source sequence(s)
      AK300487, BC022463
      Consensus CDS
      CCDS4380.1
      UniProtKB/Swiss-Prot
      D3DQL9, P28562, Q2V508
      UniProtKB/TrEMBL
      B4DRR4
      Related
      ENSP00000239223.3, ENST00000239223.4
      Conserved Domains (2) summary
      cd01446
      Location:7 → 136
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14638
      Location:174 → 324
      DSP_DUSP1; dual specificity phosphatase domain of dual specificity protein phosphatase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      172768096..172771195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      173308211..173311310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28562.3 GenPept UniProtKB/Swiss-Prot:P28562

    PreferencesTurn off
    External link. Please review our privacy policy.