MAPK1 mitogen-activated protein kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPK1provided by HGNC
Official Full Name: mitogen-activated protein kinase 1provided by HGNC
Primary source: HGNC:HGNC:6871
See related: Ensembl:ENSG00000100030 MIM:176948; AllianceGenome:HGNC:6871
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERK; p38; p40; p41; ERK2; ERT1; NS13; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
Summary: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in brain (RPKM 63.3), thyroid (RPKM 32.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q11.22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (21759657..21867680, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (22173148..22281196, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (22113946..22221970, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CARM1 phosphorylation at S595 by p38gamma MAPK drives ROS-mediated cellular senescence.
Title: CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence.
MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation.
Title: MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation.
Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export.
Title: Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export.
LncRNA PVT1 inhibits endothelial cells apoptosis in coronary heart disease through regulating MAPK1 expression via miR-532-3p.
Title: LncRNA PVT1 inhibits endothelial cells apoptosis in coronary heart disease through regulating MAPK1 expression via miR-532-3p.
Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
Title: Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression.
Title: Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression.
Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
Title: Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
Title: ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
PP4R1 promotes glycolysis and gallbladder cancer progression through facilitating ERK1/2 mediated PKM2 nuclear translocation.
Title: PP4R1 promotes glycolysis and gallbladder cancer progression through facilitating ERK1/2 mediated PKM2 nuclear translocation.
Circ-LDLRAD3/miR-655-3p/MAPK1 axis enhances cell migration and invasion in papillary thyroid carcinoma.
Title: Circ-LDLRAD3/miR-655-3p/MAPK1 axis enhances cell migration and invasion in papillary thyroid carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (1625)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Noonan syndrome 13 MedGen: C5436773 OMIM: 619087 GeneReviews: Noonan Syndrome	not available

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of ERK2 by siRNA decreases incorporation of ERK2 into virions, leading to the decreased infectivity of the ERK2-defective virus in TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env (gp120) binds to CD209 (DC-SIGN), which activates NFKB1 (NF-kB), MAPK1 (ERK1/2), and MAPK14 (p38)	PubMed
	env	HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation	PubMed
	env	HIV-1 gp120 induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells	PubMed
	env	HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38	PubMed
	env	HIV-1 gp120 induces nuclear localization of the phosphoinositide-specific phospholipase C (PI-PLC) beta 1 isozyme in MDMs, which requires activation of the MAPK ERK1/2 pathway	PubMed
	env	HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2	PubMed
	env	Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway	PubMed
	env	NHERF1 increases ERK1/2 phosphorylation levels following HIV-1 gp120 stimulation in cells	PubMed
	env	HIV-1 X4-tropic gp120 upregulates alpha-SMA (ACTA2) and collagen I alpha 1 expression via the ERK1/2 pathway in a CXCR4-dependent manner in activated human hepatic stellate cells	PubMed
	env	Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha	PubMed
	env	HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and an ERK signaling pathway	PubMed
	env	HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in macrophages and primary human central nervous system (CNS) cells	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK	PubMed
Envelope surface glycoprotein gp160, precursor	env	The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells	PubMed
	env	Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin	PubMed
Envelope transmembrane glycoprotein gp41	env	The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6	PubMed
	env	HIV-1 gp41 is able to activate the ERK/MAPK pathway by binding to CD74	PubMed
Nef	nef	HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1	PubMed
	nef	HIV-1 Nef induces phosphorylation of MAPK1 (ERK2) in M2-type macrophages	PubMed
	nef	HIV-1 Nef expression in a human astrocytic cell line inhibits the endothelin-1 mediated activation of ERK1 and ERK2 activity	PubMed
	nef	The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation	PubMed
	nef	HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi	PubMed
	nef	HIV-1 Nef-induced relocalization of LCK increases phosphorylated ERK1/2 induction in infected and trasduced primary T cells	PubMed
	nef	Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells	PubMed
	nef	The formation of Nef/LCK/PKCtheta complex activates the ERK MAPK signaling pathway	PubMed
	nef	HIV-1 Nef and ALK are capable of cumulatively influencing the MAP-K phosphorylation in astrocytic glioma cells	PubMed
	nef	HIV-1 Nef upregulates ICAM-1 expression on endothelial cells via Erk /Mapk signaling pathway	PubMed
	nef	A proline-rich repeat sequence [(Pxx)4] in HIV-1 Nef occurring between amino acid residues 69 to 78 binds to MAPK and significantly decreases its kinase activity in vitro	PubMed
	nef	HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes	PubMed
	nef	HIV-1 Nef induces ERK/MAPK signaling, which is essential for Nef-mediated Bcl-XL upregulation and cell survival in TF-1 macrophages cells	PubMed
	nef	In human and murine monocyte-macrophages, HIV-1 Nef induces both DNA binding and transcriptional activities of the activator protein-1 (AP-1) through an association with ERK1 and 2 signaling pathways	PubMed
	nef	HIV-1 Nef-induced Fas ligand transcription is regulated by p38 MAPK-mediated activator protein-1 (AP-1) activation	PubMed
	nef	HIV-1 Nef expression in primary CD4 T cells upregulates ERK, MEK, and Elk induction in a T cell receptor stimulation dependent manner, leading to enhanced viral replication and infectivity	PubMed
	nef	Phospho-MAPK1,2 and phospho-Stat3 staining increase in podocytes of kidneys from HIV-associated nephropathy patients, suggesting HIV-1 Nef-induced activation of these pathways is responsible for podocyte proliferation and dedifferentiation	PubMed
	nef	MAPK and JNK activities are activated in the presence of HIV-1 Nef after TNF-alpha treatment in human glial cells	PubMed
	nef	The activation of extracellular signal-regulated kinase 2 (ERK2) by endothelin-1 (ET-1) is inhibited by HIV-1 Nef in human astrocytes; a similar inhibitory action of Nef on ERK2 activation was observed after direct stimulation of G proteins	PubMed
Pr55(Gag)	gag	ERK2 phosphorylates HIV-1 CA at position Ser16 residue after the initiation of HIV-1 Gag processing by HIV-1 PR	PubMed
	gag	The CA region of HIV-1 Gag interacts with MAPK/ERK2 and sequentially encapsidates MAPK/ERK2 into virus particles. A domain comprising amino acids 56-110 in CA is critical for Gag interaction with MAPK/ERK2	PubMed
	gag	The p6 protein of HIV-1 Gag is phosphorylated by cellular kinases with ERK1 and ERK2 being the most likely kinases involved in p6 phosphorylation	PubMed
	gag	Phosphorylation of the Matrix protein of HIV-1 Gag on tyrosine and serine facilitates dissociation of Matrix from the cellular membrane, thus allowing it to translocate to the nucleus and participate in HIV-1 nuclear import	PubMed
	gag	Recombinant MAPK phosphorylates the Matrix protein of HIV-1 Gag on serine and threonine residues, whereas immunoprecipitated MAPK predominantly phosphorylates Matrix on serine residues	PubMed
Rev	rev	MAPK has been shown to phosphorylate Rev in vitro	PubMed
Tat	tat	HIV-1 Tat protein activates RELA (p65), MAP kinases ERK1/2 and p38, and PKC-bII in a TLR4-dependent manner in human monocytes	PubMed
	tat	HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat	PubMed
	tat	HIV-1 Tat induces phosphorylation of MAPK1 (ERK2) in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes	PubMed
	tat	Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression	PubMed
	tat	Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells	PubMed
	tat	Treatment with HIV-1 Tat and cocaine activates Ras/Erk pathway in human pulmonary artery endothelial cells	PubMed
	tat	Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells	PubMed
	tat	The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes	PubMed
	tat	HIV-1 Tat induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells	PubMed
	tat	HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways	PubMed
	tat	HIV-1 Tat induces ERK phosphorylation by the activation of the small GTPase Ras, but not the small GTPase Rac, in human endothelial cells	PubMed
	tat	Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38	PubMed
	tat	HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells	PubMed
	tat	HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation	PubMed
	tat	Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2	PubMed
	tat	HIV-1 Tat-linked intracellular third loop of the endothelin-1 type B receptor markedly enhances the endothelin-1 activation of ERK in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells	PubMed
	tat	The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells	PubMed
	tat	HIV-1 Tat inhibits the LPS-activation of ERK1/2 but not the p38 mitogen-activated protein kinases in primary blood monocytes/macrophages	PubMed
	tat	Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat	PubMed
	tat	Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3	PubMed
	tat	Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor	PubMed
	tat	Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells	PubMed
	tat	HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1)	PubMed
	tat	Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10	PubMed
	tat	Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways	PubMed
	tat	The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway	PubMed
	tat	HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes	PubMed
	tat	HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells	PubMed
	tat	Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT	PubMed
	tat	HIV-1 Tat alters the properties of human neural precursor cells via attenuation of the cell cycle regulatory unit cyclin D1 and the mitogen-activated protein kinase (MAPK) pathway, particularly extracellular signal-related kinase 1/2 (ERK1/2)	PubMed
	tat	HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT)	PubMed
	tat	HIV-1 Tat activates ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as suppression of p35 activator of cdk5, activation of CREB and increased albumin permeability	PubMed
	tat	Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter	PubMed
	tat	HIV-1 Tat is phosphorylated by MAPK in vitro	PubMed
	tat	The interaction of HIV-1 Tat with KDR/VEGFR2 is implicated in the activation of ERK1 and ERK2 signaling pathways	PubMed
Vif	vif	MAPK phosphorylates HIV-1 Vif on Thr96 and Ser165 and is important in the regulation of HIV-1 infectivity by Vif	PubMed
Vpr	vpr	HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation	PubMed
capsid	gag	ERK2 is incorporated into newly formed viral particles via its interaction with HIV-1 Gag and phosphorylates HIV-1 CA at Ser16 residue in virions. ERK2-packaging-defective virus exhibits lower infectivity than control virus	PubMed
integrase	gag-pol	Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that MAPK1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with MAPK1	PubMed
matrix	gag	HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways	PubMed
	gag	HIV-1 p17 variant S75X shows a similar activity to p17delta36 in modulating ERK1/2 signalling pathway in Raji and human primary B cells	PubMed
	gag	Expression of Pokeweed antiviral protein (PAP), a plant-derived N-glycosidase, activates the ERK1/2 MAPK pathway to a limited extent, resulting in increased phosphorylation of HIV-1 MA	PubMed
	gag	HIV-1 p17 induces phosphorylation of ERK1/ERK2 in human endothelial cells	PubMed
	gag	HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway	PubMed
	gag	HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor	PubMed
	gag	Phosphorylation of HIV-1 Matrix on tyrosine and serine prior to and during virus infection facilitates dissociation of Matrix from the cellular membrane, thus allowing it to translocate to the nucleus and participate in HIV-1 nuclear import	PubMed
	gag	Recombinant MAPK phosphorylates HIV-1 Matrix on serine and threonine residues, whereas immunoprecipitated MAPK predominantly phosphorylates HIV-1 Matrix on serine residues	PubMed
p6	gag	HIV-1 p6-Gag is phosphorylated by cellular kinases with ERK1 and ERK2 being the most likely kinases involved in p6 phosphorylation	PubMed
reverse transcriptase	gag-pol	MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S1011E (e-PCR)
- UniSTS:150799

D22S1022E (e-PCR)
- UniSTS:150803

SHGC-172572 (e-PCR)
- UniSTS:183602

G30303 (e-PCR)
- UniSTS:81521

RH47000 (e-PCR)
- UniSTS:34196

Mapk1 (e-PCR), detects polymorphism
- UniSTS:143825

MAPK1_921 (e-PCR)
- UniSTS:277477

MAPK1_V207 (e-PCR)
- UniSTS:277477

SHGC-34055 (e-PCR)
- UniSTS:58607

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	TAS Traceable Author Statement more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Bergmann glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in ERBB signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB2-ERBB3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERK1 and ERK2 cascade	IC Inferred by Curator more info	PubMed
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Schwann cell development	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cardiac neural crest cell development involved in heart development	IEA Inferred from Electronic Annotation more info
involved_in caveolin-mediated endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in cytosine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in face development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	NAS Non-traceable Author Statement more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in outer ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of macrophage chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of macrophage proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progesterone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of Golgi inheritance	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cellular pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of early endosome to late endosome transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stress-activated MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to epidermal growth factor	IDA Inferred from Direct Assay more info	PubMed
involved_in response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in steroid hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
involved_in trachea formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	TAS Traceable Author Statement more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in early endosome	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase 1

Names: MAP kinase 1; MAP kinase 2; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; protein tyrosine kinase ERK2

NP_002736.3

EC 2.7.11.24

NP_620407.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023054.2 RefSeqGene

Range

5001..113024

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_786

mRNA and Protein(s)

NM_002745.5 → NP_002736.3 mitogen-activated protein kinase 1

See identical proteins and their annotated locations for NP_002736.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AP000553, AP000554, AP000555, BC017832, BC099905

Consensus CDS

CCDS13795.1

UniProtKB/Swiss-Prot

A8CZ64, P28482

UniProtKB/TrEMBL

Q1HBJ4, Q499G7

Related

ENSP00000215832.7, ENST00000215832.11

Conserved Domains (1) summary

cd07849
Location:19 → 353

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
NM_138957.3 → NP_620407.1 mitogen-activated protein kinase 1

See identical proteins and their annotated locations for NP_620407.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a different 3' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC017832, BQ774391

Consensus CDS

CCDS13795.1

UniProtKB/Swiss-Prot

A8CZ64, P28482

UniProtKB/TrEMBL

Q1HBJ4, Q499G7

Related

ENSP00000381803.3, ENST00000398822.7

Conserved Domains (1) summary

cd07849
Location:19 → 353

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases