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    kif2c kinesin family member 2C [ Danio rerio (zebrafish) ]

    Gene ID: 100136875, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kif2cprovided by ZNC
    Official Full Name
    kinesin family member 2Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-298
    See related
    Ensembl:ENSDARG00000076228 AllianceGenome:ZFIN:ZDB-GENE-070912-298
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-61f14.1
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in cytoskeleton and kinetochore. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule cytoskeleton. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kif2c in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (33926948..33949972)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (33943711..33966754)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487475 Neighboring gene microRNA 27a Neighboring gene microRNA mir-24b Neighboring gene patched 2 Neighboring gene eukaryotic translation initiation factor 2B, subunit 3 gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. MEF2C contributes to axonal branching by regulating Kif2c transcription. Wu R, et al. Eur J Neurosci, 2024 Jun. PMID 38663879
    2. Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of kif2a in Zebrafish. Partoens M, et al. eNeuro, 2021 Sep-Oct. PMID 34404749, Free PMC Article
    3. Comprehensive Transcriptome Analysis Reveals Sex-Specific Alternative Splicing Events in Zebrafish Gonads. Lin X, et al. Life (Basel), 2022 Sep 16. PMID 36143477, Free PMC Article
    4. Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish. Oh CK, et al. Int J Mol Sci, 2020 Apr 28. PMID 32354205, Free PMC Article
    5. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Bogdanović O, et al. Nat Genet, 2016 Apr. PMID 26928226, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEF2C contributes to axonal branching by regulating Kif2c transcription.
      Title: MEF2C contributes to axonal branching by regulating Kif2c transcription.
    2. Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish.
      Title: Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114593.1 → NP_001108065.1  kinesin-like protein KIF2C

      See identical proteins and their annotated locations for NP_001108065.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155585
      UniProtKB/TrEMBL
      A0A8M1NHQ3, A9JRA8
      Related
      ENSDARP00000099090.1, ENSDART00000111430.2
      Conserved Domains (2) summary
      cd01367
      Location:256 → 584
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:262 → 585
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      33926948..33949972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163472.5 → XP_005163529.1  kinesin-like protein KIF2C isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAP1, B0S7G2
      Related
      ENSDARP00000102193.3, ENSDART00000109849.5
      Conserved Domains (2) summary
      cd01367
      Location:267 → 595
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:273 → 596
      Kinesin; Kinesin motor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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