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    ABI3BP ABI family member 3 binding protein [ Homo sapiens (human) ]

    Gene ID: 25890, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ABI3BPprovided by HGNC
    Official Full Name
    ABI family member 3 binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17265
    See related
    Ensembl:ENSG00000154175 MIM:606279; AllianceGenome:HGNC:17265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TARSH; NESHBP
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including extracellular matrix organization; positive regulation of cell-substrate adhesion; and regulation of postsynapse organization. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in gall bladder (RPKM 33.8), lung (RPKM 26.2) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ABI3BP in Genome Data Viewer
    Location:
    3q12.2
    Exon count:
    68
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100749156..100993421, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103454905..103699234, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100468000..100712265, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC124906260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63759 Neighboring gene Sharpr-MPRA regulatory region 7106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63902 Neighboring gene Sharpr-MPRA regulatory region 14979 Neighboring gene ABRAXAS1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 865, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13899 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:100847709-100847923 Neighboring gene OCT4 hESC enhancer GRCh37_chr3:100917183-100917684 Neighboring gene small nucleolar RNA U13 Neighboring gene ACTR3 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Antiviral Effect of Extracellular Matrix Protein ABI3BP on Vesicular Stomatitis Virus and Its Mechanism: A Preliminary Study In Vitro. Meng XB, et al. Chin Med Sci J, 2024 Mar. PMID 38384000
    2. Cancer-associated loss of TARSH gene expression in human primary lung cancer. Terauchi K, et al. J Cancer Res Clin Oncol, 2006 Jan. PMID 16205947
    3. Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. Latini FR, et al. Endocr Relat Cancer, 2008 Sep. PMID 18559958, Free PMC Article
    4. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Zhang F, et al. Hum Genet, 2014 Jun. PMID 24442417
    5. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. Matsuda S, et al. J Hum Genet, 2001. PMID 11501947

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Antiviral Effect of Extracellular Matrix Protein ABI3BP on Vesicular Stomatitis Virus and Its Mechanism: A Preliminary Study In Vitro.
      Title: Antiviral Effect of Extracellular Matrix Protein ABI3BP on Vesicular Stomatitis Virus and Its Mechanism: A Preliminary Study In Vitro.
    2. A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.
      Title: A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.
    3. The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma.
      Title: The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma.
    4. The current study clarifies that MALAT1 silencing and ABI3BP elevation impede the GBC development through the H3K27 methylation suppression induced by EZH2, highlighting a promising competitive paradigm for therapeutic approaches of GBC.
      Title: Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.
    5. ABI3BP is a susceptibility gene for Kashin-Beck disease in the Chinese Han population.
      Title: Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease.
    6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study of suicide attempts in mood disorder patients.
    7. These results suggest that TARSH plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development.
      Title: Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    9. The loss of ABI3BP expression could play a functional role in thyroid tumorigenesis.
      Title: Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion.
    10. Thus, TARSH presumably represents a trigger gene for evoking cellular senescence, which has also been suggested to be involved in the prevention of tumorigenesis.
      Title: Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
    EBI GWAS Catalog
    Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41743, FLJ41754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region HDA PubMed 
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    target of Nesh-SH3
    Names
    ABI family, member 3 (NESH) binding protein
    ABI gene family member 3-binding protein
    ABI gene family, member 3 (NESH) binding protein
    nesh-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001349329.2 → NP_001336258.2  target of Nesh-SH3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:700 → 1197
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:1080 → 1332
      PRK10263; DNA translocase FtsK; Provisional
      cd00063
      Location:1479 → 1570
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001349330.2 → NP_001336259.2  target of Nesh-SH3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:670 → 1127
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:1010 → 1262
      PRK10263; DNA translocase FtsK; Provisional
      cd00063
      Location:1409 → 1500
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. NM_001349331.2 → NP_001336260.2  target of Nesh-SH3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      Consensus CDS
      CCDS93332.1
      UniProtKB/TrEMBL
      A0A1S5UZ16, H7C556
      Related
      ENSP00000419029.3, ENST00000486770.7
      Conserved Domains (4) summary
      PHA03247
      Location:422 → 845
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:986 → 1077
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:116 → 195
      fn3; Fibronectin type III domain
      pfam17823
      Location:289 → 546
      DUF5585; Family of unknown function (DUF5585)

    4. NM_001349332.2 → NP_001336261.2  target of Nesh-SH3 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0A1S5UZ16
      Conserved Domains (4) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:257 → 591
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:422 → 832
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00063
      Location:857 → 948
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. NM_001365642.2 → NP_001352571.2  target of Nesh-SH3 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0A1S5UZ16
      Conserved Domains (3) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:447 → 867
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:1108 → 1199
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. NM_001365643.2 → NP_001352572.2  target of Nesh-SH3 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC080014, AC093009, AC106721
      Consensus CDS
      CCDS93333.1
      UniProtKB/TrEMBL
      F6R962, Q5JPC9
      Related
      ENSP00000433993.2, ENST00000495063.6
      Conserved Domains (2) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:471 → 926
      PHA03247; large tegument protein UL36; Provisional

    7. NM_001375547.2 → NP_001362476.1  target of Nesh-SH3 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      Consensus CDS
      CCDS93334.1
      UniProtKB/TrEMBL
      A0AA34QVJ5, D3YTG3
      Related
      ENSP00000420524.2, ENST00000471714.6
      Conserved Domains (4) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:771 → 1268
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:1151 → 1403
      PRK10263; DNA translocase FtsK; Provisional
      cd00063
      Location:1550 → 1641
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    8. NM_001375549.2 → NP_001362478.1  target of Nesh-SH3 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:771 → 1268
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:1151 → 1387
      PRK10263; DNA translocase FtsK; Provisional
      cd00063
      Location:1534 → 1625
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    9. NM_001375550.1 → NP_001362479.1  target of Nesh-SH3 isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:757 → 1254
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:1137 → 1389
      PRK10263; DNA translocase FtsK; Provisional
      cd00063
      Location:1536 → 1627
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    10. NM_001377332.1 → NP_001364261.1  target of Nesh-SH3 isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      PTZ00449
      Location:900 → 1258
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03247
      Location:533 → 1073
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:1301 → 1392
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:116 → 195
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    11. NM_015429.4 → NP_056244.3  target of Nesh-SH3 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068763, AC069223, AC080014, AC093009, AC106721
      Consensus CDS
      CCDS46880.2
      UniProtKB/Swiss-Prot
      B3KSL4, Q6ZW20, Q6ZW22, Q7Z7G0, Q9C082, Q9UFI6
      UniProtKB/TrEMBL
      A0A1S5UZ16
      Related
      ENSP00000284322.6, ENST00000284322.10
      Conserved Domains (4) summary
      PTZ00449
      Location:477 → 789
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00060
      Location:117 → 195
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:257 → 591
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:832 → 923
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      100749156..100993421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713572.4 → XP_006713635.1  target of Nesh-SH3 isoform X39

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1483 → 1574
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    2. XM_047447926.1 → XP_047303882.1  target of Nesh-SH3 isoform X45

    3. XM_047447922.1 → XP_047303878.1  target of Nesh-SH3 isoform X41

    4. XM_024453445.2 → XP_024309213.1  target of Nesh-SH3 isoform X46

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      cd00063
      Location:1463 → 1554
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:123 → 202
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl26464
      Location:724 → 1181
      Atrophin-1; Atrophin-1 family
      cl28087
      Location:1064 → 1316
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    5. XM_047447921.1 → XP_047303877.1  target of Nesh-SH3 isoform X38

    6. XM_047447920.1 → XP_047303876.1  target of Nesh-SH3 isoform X36

    7. XM_005247299.5 → XP_005247356.1  target of Nesh-SH3 isoform X29

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1508 → 1599
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    8. XM_011512641.3 → XP_011510943.1  target of Nesh-SH3 isoform X10

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      smart00060
      Location:124 → 202
      FN3; Fibronectin type 3 domain
      PHA03247
      Location:753 → 1250
      PHA03247; large tegument protein UL36; Provisional
      PRK10263
      Location:1133 → 1385
      PRK10263; DNA translocase FtsK; Provisional
      cd00063
      Location:1532 → 1623
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    9. XM_011512648.3 → XP_011510950.1  target of Nesh-SH3 isoform X25

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1511 → 1602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    10. XM_047447919.1 → XP_047303875.1  target of Nesh-SH3 isoform X33

    11. XM_047447914.1 → XP_047303870.1  target of Nesh-SH3 isoform X20

    12. XM_047447917.1 → XP_047303873.1  target of Nesh-SH3 isoform X30

    13. XM_047447925.1 → XP_047303881.1  target of Nesh-SH3 isoform X44

    14. XM_047447918.1 → XP_047303874.1  target of Nesh-SH3 isoform X32

    15. XM_047447915.1 → XP_047303871.1  target of Nesh-SH3 isoform X21

    16. XM_005247288.4 → XP_005247345.1  target of Nesh-SH3 isoform X7

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1533 → 1624
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    17. XM_006713571.4 → XP_006713634.1  target of Nesh-SH3 isoform X37

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1485 → 1576
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    18. XM_011512640.3 → XP_011510942.1  target of Nesh-SH3 isoform X6

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1535 → 1626
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    19. XM_011512643.3 → XP_011510945.1  target of Nesh-SH3 isoform X13

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1530 → 1621
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    20. XM_011512647.3 → XP_011510949.1  target of Nesh-SH3 isoform X23

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1512 → 1603
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    21. XM_047447923.1 → XP_047303879.1  target of Nesh-SH3 isoform X42

    22. XM_047447911.1 → XP_047303867.1  target of Nesh-SH3 isoform X17

    23. XM_011512646.3 → XP_011510948.1  target of Nesh-SH3 isoform X16

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1526 → 1617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    24. XM_005247295.4 → XP_005247352.1  target of Nesh-SH3 isoform X24

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1511 → 1602
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    25. XM_024453444.2 → XP_024309212.1  target of Nesh-SH3 isoform X22

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (4) summary
      smart00060
      Location:124 → 202
      FN3; Fibronectin type 3 domain
      cd00063
      Location:1512 → 1603
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl26464
      Location:803 → 1230
      Atrophin-1; Atrophin-1 family
      cl28087
      Location:1113 → 1365
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    26. XM_005247289.4 → XP_005247346.1  target of Nesh-SH3 isoform X8

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1532 → 1623
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    27. XM_047447924.1 → XP_047303880.1  target of Nesh-SH3 isoform X43

    28. XM_005247303.4 → XP_005247360.1  target of Nesh-SH3 isoform X40

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1470 → 1561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    29. XM_011512651.3 → XP_011510953.1  target of Nesh-SH3 isoform X35

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1490 → 1581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    30. XM_005247296.4 → XP_005247353.1  target of Nesh-SH3 isoform X26

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1510 → 1601
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    31. XM_047447912.1 → XP_047303868.1  target of Nesh-SH3 isoform X18

    32. XM_005247284.4 → XP_005247341.1  target of Nesh-SH3 isoform X1

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1538 → 1629
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    33. XM_011512649.3 → XP_011510951.1  target of Nesh-SH3 isoform X27

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1509 → 1600
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    34. XM_011512644.3 → XP_011510946.1  target of Nesh-SH3 isoform X14

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1529 → 1620
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    35. XM_011512639.3 → XP_011510941.1  target of Nesh-SH3 isoform X4

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1537 → 1628
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    36. XM_005247285.4 → XP_005247342.1  target of Nesh-SH3 isoform X3

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1537 → 1628
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    37. XM_005247298.4 → XP_005247355.1  target of Nesh-SH3 isoform X28

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1509 → 1600
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    38. XM_011512645.3 → XP_011510947.1  target of Nesh-SH3 isoform X15

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1529 → 1620
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    39. XM_017006105.3 → XP_016861594.1  target of Nesh-SH3 isoform X2

      UniProtKB/TrEMBL
      A0AA34QVJ5

    40. XM_017006106.3 → XP_016861595.1  target of Nesh-SH3 isoform X11

      UniProtKB/TrEMBL
      A0AA34QVJ5

    41. XM_005247287.4 → XP_005247344.1  target of Nesh-SH3 isoform X5

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1535 → 1626
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    42. XM_005247293.4 → XP_005247350.1  target of Nesh-SH3 isoform X19

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1521 → 1612
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    43. XM_005247301.4 → XP_005247358.1  target of Nesh-SH3 isoform X34

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1490 → 1581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    44. XM_006713569.4 → XP_006713632.1  target of Nesh-SH3 isoform X31

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1506 → 1597
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    45. XM_005247291.4 → XP_005247348.1  target of Nesh-SH3 isoform X12

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1531 → 1622
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    46. XM_005247290.4 → XP_005247347.1  target of Nesh-SH3 isoform X9

      UniProtKB/TrEMBL
      A0AA34QVJ5
      Conserved Domains (2) summary
      cd00063
      Location:1532 → 1623
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:123 → 211
      fn3; Fibronectin type III domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      103454905..103699234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346084.1 → XP_054202059.1  target of Nesh-SH3 isoform X68

    2. XM_054346083.1 → XP_054202058.1  target of Nesh-SH3 isoform X67

    3. XM_054346080.1 → XP_054202055.1  target of Nesh-SH3 isoform X64

    4. XM_054346066.1 → XP_054202041.1  target of Nesh-SH3 isoform X50

    5. XM_054346064.1 → XP_054202039.1  target of Nesh-SH3 isoform X48

    6. XM_054346062.1 → XP_054202037.1  target of Nesh-SH3 isoform X45

    7. XM_054346058.1 → XP_054202033.1  target of Nesh-SH3 isoform X41

    8. XM_054346056.1 → XP_054202031.1  target of Nesh-SH3 isoform X38

    9. XM_054346073.1 → XP_054202048.1  target of Nesh-SH3 isoform X57

    10. XM_054346072.1 → XP_054202047.1  target of Nesh-SH3 isoform X56

    11. XM_054346055.1 → XP_054202030.1  target of Nesh-SH3 isoform X36

    12. XM_054346049.1 → XP_054202024.1  target of Nesh-SH3 isoform X29

    13. XM_054346081.1 → XP_054202056.1  target of Nesh-SH3 isoform X65

    14. XM_054346079.1 → XP_054202054.1  target of Nesh-SH3 isoform X63

    15. XM_054346077.1 → XP_054202052.1  target of Nesh-SH3 isoform X61

    16. XM_054346067.1 → XP_054202042.1  target of Nesh-SH3 isoform X51

    17. XM_054346053.1 → XP_054202028.1  target of Nesh-SH3 isoform X33

    18. XM_054346046.1 → XP_054202021.1  target of Nesh-SH3 isoform X20

    19. XM_054346074.1 → XP_054202049.1  target of Nesh-SH3 isoform X58

    20. XM_054346065.1 → XP_054202040.1  target of Nesh-SH3 isoform X49

    21. XM_054346050.1 → XP_054202025.1  target of Nesh-SH3 isoform X30

    22. XM_054346061.1 → XP_054202036.1  target of Nesh-SH3 isoform X44

    23. XM_054346052.1 → XP_054202027.1  target of Nesh-SH3 isoform X32

    24. XM_054346047.1 → XP_054202022.1  target of Nesh-SH3 isoform X21

    25. XM_054346039.1 → XP_054202014.1  target of Nesh-SH3 isoform X7

    26. XM_054346078.1 → XP_054202053.1  target of Nesh-SH3 isoform X62

    27. XM_054346082.1 → XP_054202057.1  target of Nesh-SH3 isoform X66

    28. XM_054346076.1 → XP_054202051.1  target of Nesh-SH3 isoform X60

    29. XM_054346075.1 → XP_054202050.1  target of Nesh-SH3 isoform X59

    30. XM_054346063.1 → XP_054202038.1  target of Nesh-SH3 isoform X47

    31. XM_054346059.1 → XP_054202034.1  target of Nesh-SH3 isoform X42

    32. XM_054346043.1 → XP_054202018.1  target of Nesh-SH3 isoform X17

    33. XM_054346070.1 → XP_054202045.1  target of Nesh-SH3 isoform X54

    34. XM_054346040.1 → XP_054202015.1  target of Nesh-SH3 isoform X8

    35. XM_054346071.1 → XP_054202046.1  target of Nesh-SH3 isoform X55

    36. XM_054346069.1 → XP_054202044.1  target of Nesh-SH3 isoform X53

    37. XM_054346068.1 → XP_054202043.1  target of Nesh-SH3 isoform X52

    38. XM_054346060.1 → XP_054202035.1  target of Nesh-SH3 isoform X43

    39. XM_054346057.1 → XP_054202032.1  target of Nesh-SH3 isoform X40

    40. XM_054346048.1 → XP_054202023.1  target of Nesh-SH3 isoform X26

    41. XM_054346044.1 → XP_054202019.1  target of Nesh-SH3 isoform X18

    42. XM_054346038.1 → XP_054202013.1  target of Nesh-SH3 isoform X1

    43. XM_054346045.1 → XP_054202020.1  target of Nesh-SH3 isoform X19

    44. XM_054346054.1 → XP_054202029.1  target of Nesh-SH3 isoform X34

    45. XM_054346051.1 → XP_054202026.1  target of Nesh-SH3 isoform X31

    46. XM_054346042.1 → XP_054202017.1  target of Nesh-SH3 isoform X12

    47. XM_054346041.1 → XP_054202016.1  target of Nesh-SH3 isoform X9

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7G0.2 GenPept UniProtKB/Swiss-Prot:Q7Z7G0

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