RXFP1 relaxin family peptide receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RXFP1provided by HGNC
Official Full Name: relaxin family peptide receptor 1provided by HGNC
Primary source: HGNC:HGNC:19718
See related: Ensembl:ENSG00000171509 MIM:606654; AllianceGenome:HGNC:19718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LGR7; RXFPR1
Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Expression: Biased expression in brain (RPKM 6.2), endometrium (RPKM 3.9) and 7 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q32.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (158521714..158653372)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (161872384..162004104)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (159442866..159574524)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The consequences of manipulating relaxin family peptide receptor 1 (RXFP1) level in ovarian cancer cells.
Title: The consequences of manipulating relaxin family peptide receptor 1 (RXFP1) level in ovarian cancer cells.
Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Title: Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1.
Title: Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1.
Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.
Title: Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.
The anti-fibrotic actions of relaxin are mediated through AT2 R-associated protein phosphatases via RXFP1-AT2 R functional crosstalk in human cardiac myofibroblasts.
Title: The anti-fibrotic actions of relaxin are mediated through AT(2) R-associated protein phosphatases via RXFP1-AT(2) R functional crosstalk in human cardiac myofibroblasts.
In mice expressing human RXFP1 gene treated with carbon tetrachloride, ML290 significantly reduced collagen content, alpha-smooth muscle actin expression, and cell proliferation around portal ducts.
Title: Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.
Idiopathic pulmonary fibrosis lung fibroblasts transfected with anti-miR-144-3p had increased RXFP1 expression and reduced alpha-smooth muscle actin expression.
Title: MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.
Binding of relaxin to RXFP1 recruits G proteins with subsequent activation of adenylyl cyclase and elevation of cAMP.
Title: Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies.
The decreased expression of the endometrial RLX receptor in women with implantation failures, both in vitro fertilization failure and recurrent pregnancy loss, suggests that RLX may play a crucial role in the structural and functional changes of the endometrium during the window of implantation.
Title: Endometrial LGR7 expression and implantation failure.
Hormone receptor expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves
Title: Hormone receptor expression in human fascial tissue.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D4S3354 (e-PCR), detects polymorphism
- UniSTS:55305

SHGC-50975 (e-PCR)
- UniSTS:19486

SHGC-67714 (e-PCR)
- UniSTS:16433

SHGC-147262 (e-PCR)
- UniSTS:175705

D4S1266 (e-PCR)
- UniSTS:36962

D4S510 (e-PCR)
- UniSTS:45967

D4S3351 (e-PCR), detects polymorphism
- UniSTS:15031

RH119197 (e-PCR)
- UniSTS:138706

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lung connective tissue development	IEA Inferred from Electronic Annotation more info
involved_in myofibroblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in nipple morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in parturition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: relaxin receptor 1

Names: leucine-rich repeat-containing G protein-coupled receptor 7; relaxin/insulin like family peptide receptor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031835.2 RefSeqGene

Range

5169..136659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001253727.2 → NP_001240656.1 relaxin receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001240656.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.

Source sequence(s)

AK294694, BX647980, BX647985

Consensus CDS

CCDS75204.1

UniProtKB/TrEMBL

B3KV27, B4DGP2

Related

ENSP00000405841.2, ENST00000423548.5

Conserved Domains (5) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:196 → 358

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:155 → 178

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:451 → 708

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:179 → 237

LRR_8; Leucine rich repeat
NM_001253728.2 → NP_001240657.1 relaxin receptor 1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001240657.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK300379, BX647980

Consensus CDS

CCDS58930.1

UniProtKB/TrEMBL

B3KV27

Related

ENSP00000420712.1, ENST00000470033.2

Conserved Domains (5) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:136 → 298

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:95 → 118

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:391 → 648

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:119 → 177

LRR_8; Leucine rich repeat
NM_001253729.2 → NP_001240658.1 relaxin receptor 1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001240658.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AY899849, BX647980, BX647985

Consensus CDS

CCDS58929.1

UniProtKB/TrEMBL

B3KV27

Related

ENSP00000345889.5, ENST00000343542.9

Conserved Domains (6) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:169 → 309

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:128 → 151

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:376 → 633

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12799
Location:152 → 191

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:152 → 210

LRR_8; Leucine rich repeat
NM_001253730.2 → NP_001240659.1 relaxin receptor 1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an internal exon, uses two alternate splice sites and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC143559, BX647980, BX647985

Consensus CDS

CCDS75205.1

UniProtKB/TrEMBL

A0A087WWV0, Q59H16

Related

ENSP00000480522.1, ENST00000613319.4

Conserved Domains (4) summary

sd00033
Location:1 → 21

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:22 → 80

LRR_8; Leucine rich repeat

cd15965
Location:275 → 561

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors

cl26161
Location:39 → 201

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001253732.2 → NP_001240661.1 relaxin receptor 1 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) includes an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB208943, BX647980, BX647985, DA308373

UniProtKB/TrEMBL

Q59H16

Conserved Domains (4) summary

sd00033
Location:24 → 43

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:24 → 78

LRR_8; Leucine rich repeat

cd15965
Location:274 → 560

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors

cl26161
Location:9 → 199

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001253733.2 → NP_001240662.1 relaxin receptor 1 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an internal exon, includes an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK122647, AK312470, BX647980, DA241507

Consensus CDS

CCDS75206.1

UniProtKB/TrEMBL

A0A0A0MT52, Q59H16

Related

ENSP00000414885.3, ENST00000448688.6

Conserved Domains (3) summary

sd00033
Location:24 → 43

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:24 → 78

LRR_8; Leucine rich repeat

cd15965
Location:250 → 536

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001363776.1 → NP_001350705.1 relaxin receptor 1 isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (8) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC019341, AC107219, AC108017, AC121161

Consensus CDS

CCDS87277.1

UniProtKB/TrEMBL

B3KV27, E9PCA3

Related

ENSP00000423306.1, ENST00000460056.6

Conserved Domains (3) summary

sd00033
Location:47 → 70

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:71 → 129

LRR_8; Leucine rich repeat

cd15965
Location:325 → 611

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors
NM_021634.4 → NP_067647.2 relaxin receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_067647.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

BX647980

Consensus CDS

CCDS43276.1

UniProtKB/Swiss-Prot

B4DHD1, B4DTV2, Q2M215, Q3KU24, Q3KU25, Q3KU26, Q9HBX9

UniProtKB/TrEMBL

B3KV27

Related

ENSP00000303248.5, ENST00000307765.10

Conserved Domains (4) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:128 → 151

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:152 → 210

LRR_8; Leucine rich repeat

cd15965
Location:406 → 692

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

NR_045579.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an exon and includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK295040, BX647980, BX647985, DA519897
NR_045580.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC143558, BX647980, BX647985
NR_045581.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC143556, BX647980, BX647985

Related

ENST00000342048.9
NR_045582.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks two consecutive internal exons and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC143557, BX647980, BX647985
NR_045583.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks an internal exon and uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK307889, BX647980, CR748189
NR_045584.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (13) contains an alternate internal exon and an alternate terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI653269, AY899848, BX647985, DA156504

Related

ENST00000471616.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

158521714..158653372

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011532179.3 → XP_011530481.1 relaxin receptor 1 isoform X7

Conserved Domains (4) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:196 → 358

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:155 → 178

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:179 → 237

LRR_8; Leucine rich repeat
XM_011532174.2 → XP_011530476.1 relaxin receptor 1 isoform X1

UniProtKB/TrEMBL

B3KV27

Conserved Domains (5) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:196 → 358

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:155 → 178

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:450 → 707

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:179 → 237

LRR_8; Leucine rich repeat
XM_011532175.2 → XP_011530477.1 relaxin receptor 1 isoform X2

UniProtKB/TrEMBL

B3KV27

Conserved Domains (5) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:167 → 334

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:155 → 178

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:427 → 684

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:179 → 237

LRR_8; Leucine rich repeat
XM_017008517.2 → XP_016864006.1 relaxin receptor 1 isoform X3

UniProtKB/TrEMBL

B3KV27
XM_017008523.3 → XP_016864012.1 relaxin receptor 1 isoform X8
XM_017008518.3 → XP_016864007.1 relaxin receptor 1 isoform X4

UniProtKB/TrEMBL

B3KV27
XM_011532176.3 → XP_011530478.1 relaxin receptor 1 isoform X5

UniProtKB/TrEMBL

B3KV27

Conserved Domains (5) summary

cd00112
Location:27 → 62

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:140 → 307

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:128 → 151

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:400 → 657

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:152 → 210

LRR_8; Leucine rich repeat
XM_017008524.3 → XP_016864013.1 relaxin receptor 1 isoform X9
XM_017008525.2 → XP_016864014.1 relaxin receptor 1 isoform X10
XM_017008520.2 → XP_016864009.1 relaxin receptor 1 isoform X6

UniProtKB/TrEMBL

B3KV27

Conserved Domains (3) summary

sd00033
Location:74 → 97

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:98 → 156

LRR_8; Leucine rich repeat

cd15965
Location:352 → 638

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017008526.2 → XP_016864015.1 relaxin receptor 1 isoform X11

UniProtKB/TrEMBL

A0A0A0MT52, Q59H16

Conserved Domains (3) summary

sd00033
Location:24 → 43

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:24 → 78

LRR_8; Leucine rich repeat

cd15965
Location:250 → 536

7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors