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    acvr1ba activin A receptor type 1Ba [ Danio rerio (zebrafish) ]

    Gene ID: 30183, updated on 28-Oct-2024

    Summary

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    Official Symbol
    acvr1baprovided by ZNC
    Official Full Name
    activin A receptor type 1Baprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-527
    See related
    Ensembl:ENSDARG00000018968 AllianceGenome:ZFIN:ZDB-GENE-980526-527
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    alk4; axis; acvr1b; tarama; taram-a; wu:fb75f01
    Summary
    Predicted to enable activin binding activity and activin receptor activity, type I. Acts upstream of or within dorsal/ventral pattern formation; fin regeneration; and formation of primary germ layer. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including DEL; blastodisc; germ ring; margin; and presumptive shield. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; malignant mesothelioma; pancreatic cancer; and stomach cancer. Orthologous to human ACVR1B (activin A receptor type 1B). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

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    See acvr1ba in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (27800519..27822920, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (27873978..27896383, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene desert hedgehog signaling molecule Neighboring gene lysine (K)-specific methyltransferase 2D Neighboring gene activin A receptor like type 1 Neighboring gene ankyrin repeat domain 33Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Inhibitory interactions controlling organizer activity in fish. Peyriéras N, et al. C R Acad Sci III, 1996 Dec. PMID 9091181
    2. An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Barone V, et al. Dev Cell, 2017 Oct 23. PMID 29033362
    3. Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Song C, et al. Gen Comp Endocrinol, 2010 Mar 1. PMID 19699739
    4. Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts. Dumortier JG, et al. Proc Natl Acad Sci U S A, 2012 Oct 16. PMID 23027928, Free PMC Article
    5. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Goudie DR, et al. Nat Genet, 2011 Feb 27. PMID 21358634

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables activin receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		  
    acts_upstream_of_or_within endoderm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within endoderm formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endodermal cell fate determination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesoderm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    activin A receptor type 1Ba
    Names
    activin A receptor, type IB
    activin A receptor, type IBa
    NP_571065.1
    XP_005162281.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130990.1 → NP_571065.1  activin A receptor type 1Ba precursor

      See identical proteins and their annotated locations for NP_571065.1

      Status: PROVISIONAL

      Source sequence(s)
      X94119
      UniProtKB/TrEMBL
      P79689
      Related
      ENSDARP00000004431.8, ENSDART00000023094.9
      Conserved Domains (4) summary
      smart00220
      Location:209 → 492
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14143
      Location:211 → 498
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:32 → 105
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:178 → 205
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      27800519..27822920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162224.5 → XP_005162281.1  activin A receptor type 1Ba isoform X1

      UniProtKB/TrEMBL
      A0A8M2B949
      Conserved Domains (4) summary
      smart00220
      Location:223 → 506
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14143
      Location:225 → 512
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:32 → 105
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:192 → 219
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
    Nucleotide Protein Strain
    Heading Accession and Version

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