ankhb ANKH inorganic pyrophosphate transport regulator b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ankhbprovided by ZNC
Official Full Name: ANKH inorganic pyrophosphate transport regulator bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2458
See related: Ensembl:ENSDARG00000014969 AllianceGenome:ZFIN:ZDB-GENE-030131-2458
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ankh; wu:fc08d03
Summary: Predicted to enable inorganic diphosphate transmembrane transporter activity and phosphate transmembrane transporter activity. Predicted to be involved in regulation of bone mineralization. Predicted to act upstream of or within phosphate ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (31957615..32006312)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (31974397..32023094)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc08d03.x1 (e-PCR)
- UniSTS:192343

fc08d03.x1 (e-PCR)
- UniSTS:192344

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables inorganic diphosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: progressive ankylosis protein homolog B

Names: ANK-B; ankylosis, progressive homolog b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194370.1 → NP_919351.1 progressive ankylosis protein homolog B

See identical proteins and their annotated locations for NP_919351.1

Status: PROVISIONAL

Source sequence(s)

AJ302035

UniProtKB/Swiss-Prot

B0UY66, P58368, Q66I27

Related

ENSDARP00000002526.7, ENSDART00000012413.8

Conserved Domains (2) summary

pfam07260
Location:1 → 345

ANKH; Progressive ankylosis protein (ANKH)

cl09326
Location:327 → 438

MATE_like; Multidrug and toxic compound extrusion family and similar proteins