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    ckap5 cytoskeleton associated protein 5 [ Danio rerio (zebrafish) ]

    Gene ID: 492614, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ckap5provided by ZNC
    Official Full Name
    cytoskeleton associated protein 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-174
    See related
    Ensembl:ENSDARG00000102674 AllianceGenome:ZFIN:ZDB-GENE-051120-174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7143385; wu:fb14c01; wu:fb59e03; wu:fi33f02; zgc:123012
    Summary
    Predicted to enable microtubule binding activity and microtubule plus end polymerase. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within spindle organization. Predicted to be active in centrosome; kinetochore; and spindle pole. Predicted to colocalize with microtubule plus-end. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ckap5 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (13745056..13790064, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (13648654..13693671, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene coiled-coil domain containing 135 Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene uncharacterized LOC110438383 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1a Neighboring gene cryptochrome circadian regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of zebrafish magnetoreceptor and cryptochrome homologs. Zhou Z, et al. Sci China Life Sci, 2016 Dec. PMID 27614751
    2. Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Liu C, et al. Sci Rep, 2015 Jan 29. PMID 25630924, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123012

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus end polymerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus end polymerase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of microtubule cytoskeleton polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytoskeleton-associated protein 5
    Names
    microtubule-associated protein 215

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037667.3 → NP_001032756.3  cytoskeleton-associated protein 5

      Status: VALIDATED

      Source sequence(s)
      FP236801
      UniProtKB/TrEMBL
      A0A0R4IQI9, A0A8M1N8C2
      Related
      ENSDARP00000139073.1, ENSDART00000171461.2
      Conserved Domains (1) summary
      PRK14951
      Location:514 → 669
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      13745056..13790064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297902.4 → XP_009296177.1  cytoskeleton-associated protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B733
      Conserved Domains (1) summary
      PRK14951
      Location:514 → 669
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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