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    PPOX protoporphyrinogen oxidase [ Homo sapiens (human) ]

    Gene ID: 5498, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PPOXprovided by HGNC
    Official Full Name
    protoporphyrinogen oxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:9280
    See related
    Ensembl:ENSG00000143224 MIM:600923; AllianceGenome:HGNC:9280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VP; PPO; VPCO; V290M
    Summary
    This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.3), skin (RPKM 3.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPOX in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161165728..161178013)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160303185..160315736)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161136216..161141010)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:161123368-161124567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1470 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161137271-161137934 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161146985-161147484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161148623-161149124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1983 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161162728-161163541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161166678-161167583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161170109-161170830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1985 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161187006-161187992 Neighboring gene Fc epsilon receptor Ig

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Extended haplotype studies in South African and Dutch variegate porphyria families carrying the recurrent p.R59W mutation confirm a common ancestry. van Tuyll van Serooskerken AM, et al. Br J Dermatol, 2012 Feb. PMID 21910705
    2. Homozygous variegate porphyria in South Africa: genotypic analysis in two cases. Corrigall AV, et al. Mol Genet Metab, 2000 Apr. PMID 10870850
    3. Homozygous variegate porphyria: 20 y follow-up and characterization of molecular defect. Kauppinen R, et al. J Invest Dermatol, 2001 Apr. PMID 11286631
    4. Clinical and biochemical characteristics and genotype-phenotype correlation in Finnish variegate porphyria patients. von und zu Fraunberg M, et al. Eur J Hum Genet, 2002 Oct. PMID 12357337
    5. Homozygous variegate porphyria: a compound heterozygote with novel mutations in the protoporphyrinogen oxidase gene. Palmer RA, et al. Br J Dermatol, 2001 Apr. PMID 11298551

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular characterization of a novel His333Arg variant of human protoporphyrinogen oxidase IX.
      Title: Molecular characterization of a novel His333Arg variant of human protoporphyrinogen oxidase IX.
    2. The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.
      Title: The hydrogen bonding network involved Arg59 in human protoporphyrinogen IX oxidase is essential for enzyme activity.
    3. Two new mutations in the PPOX gene in a patient with variegate porphyria.
      Title: Two new mutations in the PPOX gene in a patient with variegate porphyria.
    4. Mount Sinai Porphyrias Diagnostic Laboratory diagnosed 54 unrelated Variegate Porphyria individuals with 20 PPOX novel mutations.
      Title: Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.
    5. The genetic test showed a heterozygous mutation in the gene encoding Protoporphyrinogen Oxidase (PPOX); c.2T > A (p.Met1Lys) on chromosome 1q23, which supports the diagnosis of Variegate Porphyria
      Title: An unusual diagnosis in a 31-year-old man with abdominal pain and hyponatremia.
    6. the regulation of PPOX gene expression can also occur through a post-transcriptional modulation of the amount of gene product and this modulation can be mediated by 5' untranslated exon 1.
      Title: The assessment of noncoding variant of PPOX gene in variegate porphyria reveals post-transcriptional role of the 5' untranslated exon 1.
    7. GAPDH and protoporphyrinogen oxidase were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH or PPOX reduced the growth of colon cancer cells in vitro
      Title: Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
    8. Variegate porphyria is the result of decreased protoporphyrinogen oxidase activity. Diet supplementation with vitamins E and C restores PPOX gene expression in lymphocytes of variegate porphyria patients.
      Title: Antioxidants restore protoporphyrinogen oxidase in variegate porphyria patients.
    9. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX and HMBS
      Title: Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias.
    10. The mutation 1082-1083insC(1 base pair insertion at position 1082) in exon 10 of the PPOX gene was prevalent in the Swiss population.
      Title: Identification of a recurrent mutation in the protoporphyrinogen oxidase gene in Swiss patients with variegate porphyria: clinical and genetic implications.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Variegate porphyria
    MedGen: C0162532 OMIM: 176200 GeneReviews: Variegate Porphyria
    		Compare labs
    Variegate porphyria, childhood-onset
    MedGen: C5882681 OMIM: 620483 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8485

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxygen-dependent protoporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme B biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme O biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial intermembrane space TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    protoporphyrinogen oxidase
    NP_000300.1
    NP_001116236.1
    NP_001337057.1
    NP_001337058.1
    NP_001337059.1
    NP_001337060.1
    NP_001352327.1
    NP_001352328.1
    NP_001352329.1
    NP_001352330.1
    XP_005245348.2
    XP_005245352.2
    XP_006711467.3
    XP_011507965.1
    XP_011507966.1
    XP_011507967.1
    XP_011507969.1
    XP_011507970.1
    XP_011507972.1
    XP_011507973.1
    XP_011507974.2
    XP_011507975.1
    XP_011507976.1
    XP_011507980.1
    XP_016857055.1
    XP_024303632.2
    XP_047279525.1
    XP_047279537.1
    XP_047279548.1
    XP_047279560.1
    XP_054193244.1
    XP_054193245.1
    XP_054193246.1
    XP_054193247.1
    XP_054193248.1
    XP_054193249.1
    XP_054193250.1
    XP_054193251.1
    XP_054193252.1
    XP_054193253.1
    XP_054193254.1
    XP_054193255.1
    XP_054193256.1
    XP_054193257.1
    XP_054193258.1
    XP_054193259.1
    XP_054193260.1
    XP_054193261.1
    XP_054193262.1
    XP_054193263.1
    XP_054193264.1
    XP_054193265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012877.2 RefSeqGene

      Range
      5036..9830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1078

    mRNA and Protein(s)

    1. NM_000309.5 → NP_000300.1  protoporphyrinogen oxidase isoform 1

      See identical proteins and their annotated locations for NP_000300.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 7 encode the same protein (isoform 1).
      Source sequence(s)
      AI357309, BC002357
      Consensus CDS
      CCDS1221.1
      UniProtKB/Swiss-Prot
      D3DVG0, P50336, Q5VTW8
      UniProtKB/TrEMBL
      A0A494C146
      Related
      ENSP00000343943.5, ENST00000352210.9
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    2. NM_001122764.3 → NP_001116236.1  protoporphyrinogen oxidase isoform 1

      See identical proteins and their annotated locations for NP_001116236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 7 encode the same protein (isoform 1).
      Source sequence(s)
      AI357309, BC002357, BX384814
      Consensus CDS
      CCDS1221.1
      UniProtKB/Swiss-Prot
      D3DVG0, P50336, Q5VTW8
      UniProtKB/TrEMBL
      A0A494C146
      Related
      ENSP00000356978.4, ENST00000367999.9
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    3. NM_001350128.2 → NP_001337057.1  protoporphyrinogen oxidase isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI357309, AL590714, BC002357, BX384814, DC399187
      UniProtKB/TrEMBL
      A0A494C0D4, B4DY76
      Conserved Domains (1) summary
      cl27533
      Location:3 → 438
      HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]

    4. NM_001350129.2 → NP_001337058.1  protoporphyrinogen oxidase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: Variants 4 and 9 encode the same protein (isoform 3).
      Source sequence(s)
      AI357309, BC002357, DA061615, DA745403, DC399187
      UniProtKB/TrEMBL
      A0A494C0D4
      Conserved Domains (1) summary
      TIGR00562
      Location:30 → 335
      proto_IX_ox; protoporphyrinogen oxidase

    5. NM_001350130.2 → NP_001337059.1  protoporphyrinogen oxidase isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: Variants 5, 6 and 10 encode the same protein (isoform 4).
      Source sequence(s)
      AI357309, BC002357, EL954312
      UniProtKB/TrEMBL
      A0A494C0D4
      Conserved Domains (1) summary
      TIGR00562
      Location:4 → 309
      proto_IX_ox; protoporphyrinogen oxidase

    6. NM_001350131.2 → NP_001337060.1  protoporphyrinogen oxidase isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: Variants 5, 6 and 10 encode the same protein (isoform 4).
      Source sequence(s)
      AI357309, BC002357, DA268550
      UniProtKB/TrEMBL
      A0A494C0D4
      Conserved Domains (1) summary
      TIGR00562
      Location:4 → 309
      proto_IX_ox; protoporphyrinogen oxidase

    7. NM_001365398.1 → NP_001352327.1  protoporphyrinogen oxidase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 2 and 7 encode the same protein (isoform 1).
      Source sequence(s)
      AL590714
      Consensus CDS
      CCDS1221.1
      UniProtKB/Swiss-Prot
      D3DVG0, P50336, Q5VTW8
      UniProtKB/TrEMBL
      A0A494C146
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    8. NM_001365399.1 → NP_001352328.1  protoporphyrinogen oxidase isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL590714
      UniProtKB/TrEMBL
      A0A494C146
      Related
      ENSP00000498884.1, ENST00000652182.1
      Conserved Domains (1) summary
      COG1232
      Location:5 → 434
      HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]

    9. NM_001365400.1 → NP_001352329.1  protoporphyrinogen oxidase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: Variants 4 and 9 encode the same protein (isoform 3).
      Source sequence(s)
      AL590714
      UniProtKB/TrEMBL
      A0A494C0D4
      Conserved Domains (1) summary
      TIGR00562
      Location:30 → 335
      proto_IX_ox; protoporphyrinogen oxidase

    10. NM_001365401.1 → NP_001352330.1  protoporphyrinogen oxidase isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: Variants 5, 6 and 10 encode the same protein (isoform 4).
      Source sequence(s)
      AL590714
      UniProtKB/TrEMBL
      A0A494C0D4
      Conserved Domains (1) summary
      TIGR00562
      Location:4 → 309
      proto_IX_ox; protoporphyrinogen oxidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161165728..161178013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423581.1 → XP_047279537.1  protoporphyrinogen oxidase isoform X5

    2. XM_011509674.3 → XP_011507976.1  protoporphyrinogen oxidase isoform X12

      Conserved Domains (2) summary
      COG1232
      Location:43 → 317
      HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    3. XM_011509670.3 → XP_011507972.1  protoporphyrinogen oxidase isoform X6

      Conserved Domains (2) summary
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:232 → 366
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_011509673.3 → XP_011507975.1  protoporphyrinogen oxidase isoform X11

      Conserved Domains (2) summary
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:182 → 316
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_011509663.3 → XP_011507965.1  protoporphyrinogen oxidase isoform X1

      Conserved Domains (2) summary
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:270 → 404
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. XM_011509665.3 → XP_011507967.1  protoporphyrinogen oxidase isoform X3

      Conserved Domains (2) summary
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:270 → 404
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_011509664.2 → XP_011507966.1  protoporphyrinogen oxidase isoform X2

      Conserved Domains (2) summary
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:265 → 399
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    8. XM_047423569.1 → XP_047279525.1  protoporphyrinogen oxidase isoform X4

    9. XM_011509671.2 → XP_011507973.1  protoporphyrinogen oxidase isoform X9

      UniProtKB/TrEMBL
      A0A494C146
      Conserved Domains (3) summary
      TIGR00562
      Location:41 → 509
      proto_IX_ox; protoporphyrinogen oxidase
      pfam13450
      Location:45 → 103
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:265 → 399
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    10. XM_011509672.4 → XP_011507974.2  protoporphyrinogen oxidase isoform X10

      UniProtKB/TrEMBL
      B4DY76

    11. XM_006711404.5 → XP_006711467.3  protoporphyrinogen oxidase isoform X8

    12. XM_024447864.2 → XP_024303632.2  protoporphyrinogen oxidase isoform X13

      Related
      ENSP00000498501.1, ENST00000652103.1

    13. XM_011509667.3 → XP_011507969.1  protoporphyrinogen oxidase isoform X5

      See identical proteins and their annotated locations for XP_011507969.1

      Conserved Domains (2) summary
      pfam13450
      Location:7 → 65
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:232 → 366
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    14. XM_005245291.5 → XP_005245348.2  protoporphyrinogen oxidase isoform X7

      See identical proteins and their annotated locations for XP_005245348.2

      Conserved Domains (2) summary
      pfam13450
      Location:7 → 65
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:227 → 361
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    15. XM_011509668.3 → XP_011507970.1  protoporphyrinogen oxidase isoform X5

      See identical proteins and their annotated locations for XP_011507970.1

      Conserved Domains (2) summary
      pfam13450
      Location:7 → 65
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:232 → 366
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    16. XM_005245295.4 → XP_005245352.2  protoporphyrinogen oxidase isoform X14

      See identical proteins and their annotated locations for XP_005245352.2

      UniProtKB/TrEMBL
      B3KT30
      Conserved Domains (1) summary
      TIGR00562
      Location:30 → 236
      proto_IX_ox; protoporphyrinogen oxidase

    17. XM_011509678.2 → XP_011507980.1  protoporphyrinogen oxidase isoform X14

      See identical proteins and their annotated locations for XP_011507980.1

      UniProtKB/TrEMBL
      B3KT30
      Conserved Domains (1) summary
      TIGR00562
      Location:30 → 236
      proto_IX_ox; protoporphyrinogen oxidase

    18. XM_017001566.3 → XP_016857055.1  protoporphyrinogen oxidase isoform X15

      UniProtKB/TrEMBL
      A0A494C0D4
      Conserved Domains (1) summary
      TIGR00562
      Location:30 → 335
      proto_IX_ox; protoporphyrinogen oxidase

    19. XM_047423604.1 → XP_047279560.1  protoporphyrinogen oxidase isoform X16

    20. XM_047423592.1 → XP_047279548.1  protoporphyrinogen oxidase isoform X14

    RNA

    1. XR_007061329.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160303185..160315736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337275.1 → XP_054193250.1  protoporphyrinogen oxidase isoform X5

    2. XM_054337282.1 → XP_054193257.1  protoporphyrinogen oxidase isoform X12

    3. XM_054337276.1 → XP_054193251.1  protoporphyrinogen oxidase isoform X6

    4. XM_054337281.1 → XP_054193256.1  protoporphyrinogen oxidase isoform X11

    5. XM_054337269.1 → XP_054193244.1  protoporphyrinogen oxidase isoform X1

    6. XM_054337271.1 → XP_054193246.1  protoporphyrinogen oxidase isoform X3

    7. XM_054337270.1 → XP_054193245.1  protoporphyrinogen oxidase isoform X2

    8. XM_054337272.1 → XP_054193247.1  protoporphyrinogen oxidase isoform X4

    9. XM_054337279.1 → XP_054193254.1  protoporphyrinogen oxidase isoform X9

    10. XM_054337280.1 → XP_054193255.1  protoporphyrinogen oxidase isoform X10

      UniProtKB/TrEMBL
      B4DY76

    11. XM_054337278.1 → XP_054193253.1  protoporphyrinogen oxidase isoform X8

    12. XM_054337284.1 → XP_054193259.1  protoporphyrinogen oxidase isoform X13

    13. XM_054337273.1 → XP_054193248.1  protoporphyrinogen oxidase isoform X5

    14. XM_054337277.1 → XP_054193252.1  protoporphyrinogen oxidase isoform X7

    15. XM_054337274.1 → XP_054193249.1  protoporphyrinogen oxidase isoform X5

    16. XM_054337288.1 → XP_054193263.1  protoporphyrinogen oxidase isoform X14

    17. XM_054337286.1 → XP_054193261.1  protoporphyrinogen oxidase isoform X14

    18. XM_054337283.1 → XP_054193258.1  protoporphyrinogen oxidase isoform X17

    19. XM_054337287.1 → XP_054193262.1  protoporphyrinogen oxidase isoform X14

    20. XM_054337285.1 → XP_054193260.1  protoporphyrinogen oxidase isoform X18

    21. XM_054337289.1 → XP_054193264.1  protoporphyrinogen oxidase isoform X15

    22. XM_054337290.1 → XP_054193265.1  protoporphyrinogen oxidase isoform X16

    RNA

    1. XR_008486082.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50336.1 GenPept UniProtKB/Swiss-Prot:P50336

    Gene LinkOut

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