Tissue-specific responses to DNA damage limit function and regulate ageing in progeroid mice

Genome-wide CRISPR screen reveals a key role for integrin avb3 in TH2 cell polarisation [CRISPRscr]

Genome-wide CRISPR screen reveals a key role for integrin avb3 in TH2 cell polarisation [RNA-seq I]

Genome-wide CRISPR screen reveals a key role for integrin avb3 in TH2 cell polarisation.

Identification of aceNKPs, a committed common progenitor of the ILC1 and NK cell continuum

An avb3 integrin checkpoint is critical for efficient TH2 cytokine polarisation and potentiating antigen-specific immunity [ChIP-seq]

An avb3 integrin checkpoint is critical for efficient TH2 cytokine polarisation and potentiating antigen-specific immunity [RNA-seq]

Single cell RNA-seq (smartseq2) analysis of the ETP population from E15.5 embryonic thymus of the 5x polychromILC mice

Single cell RNA-seq (10X Chromium 3') analysis of the DN1 population from E15.5 embryonic thymus of the 5x polychromILC mice

Examination of gene expression in different populations of the embryonic thymus at E15.5 and E19.5 by bulk RNA-seq

Examination of RORa and GATA-3 binding sites in ILC2 by ChIP-seq

Examination of genomic accessibility in embryonic thymus cell populations by ATAC-seq

RORa expression is a critical checkpoint for the bifurcation of the T cell and ILC2 lineages in the embryonic thymus

Polychromic reporter mice reveal unappreciated innate lymphoid cell progenitor heterogeneity and elusive ILC3 progenitors in bone marrow