Iterative deep learning-design of human enhancers exploits condensed sequence grammar to achieve cell type-specificity [RNA-Seq]

Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2 (Screen)

T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

Context dependent activity of p63-bound gene regulatory elements

Study of microbial species in extracellular vesicles of sclerosis multiple patients

Deep mutational scanning quantifies DNA binding and predicts clinical outcomes of PAX6 variants

Synthetic genetic circuit reveals overlapping binding sites underlie TF genomic occupancy

Ankrd11, a chromatin regulator and a KBG syndrome risk gene, is a critical regulator of cardiac neural crest cell biology and heart development [MERSCOPE]

A mutational atlas for Parkin

Deep mutational scanning reveals a tight correlation between protein degradation and toxicity of thousands of non-native aspartoacylase protein variants

MERFISH reveals embryonic endothelial heterogeneity

Proliferative Receptor Binding Domain (RBD)-specific CD4+ T cells correlate with neutralizing antibody levels after natural SARS-CoV-2 infection and are induced following vaccination

Analysis of the overlapping tri-nucleosome association with genomic and synthetic DNA

DMS-MapSeq Analysis of Antisense Oligonucleotide Binding to lncRNA PANDA

Macrophage Mannose receptor (MRC1) mediates uptake of dextran in murine bone-marrow derived macrophages via a receptor-mediated endocytic process

Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas

Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity 

Spatial Transcriptomics correlated Electron Microscopy [MERFISH]

Spatial Transcriptomics correlated Electron Microscopy

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay