IL-18-secreting multi-antigen targeting CAR T-cells eliminate antigen-low myeloma in an immunocompetent mouse model [in vivo]

A Lactate-induced SREBF2-dependent genetic program drives an immunotolerant dendritic cell population during cancer progression

Dissecting developmental disorders caused by CTCF mutation at R567 [SPARC-seq]

Dissecting developmental disorders caused by CTCF mutation at R567

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program. scRNA-Seq profiling of mouse tissue Tregs with TCR sequencing and CITE-Seq

CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

Maternal Schistosomaisis Early bone marrow B cell scRNA CITEseq

Histone lactylation antagonizes senescence via facilitating gene-expression reprogramming.

Well-ST-seq: cost-effective and cellular level spatial transcriptomics with high RNA capture efficiency

Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1

A critical requirement for IκBα in controlling dormancy in Hematopoietic stem cells via retinoic acid during embryonic development

Single-cell multimodal profiling of atherosclerosis identifies CD200 as a cell surface lineage marker of vascular smooth muscle cells and their derived cells

Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation

Spatial transcriptomic analysis of Nf1+/- mouse brain

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer

Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease

in situ Hi-C profiles of DP thymocyltes from control and Suv39h1/Suv39h2 double knockout mice

RNA-seq, LaminB1 ChIP-seq and in situ Hi-C of double positive thymocytes from control and Suv39h1/Suv39h2 double knockout mice

Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release in a spatial manner to amplify liver fibrosis