HumanHap300-2 v2.0 Genotyping BeadChip provides genome-wide coverage using >318,000 tag SNPs chosen from the International HapMap Project.
The HumanHap300-Duo BeadChip is a two-sample format and contains: • >318,000 tag SNPs derived from the Phase I and II HapMap data, >42,000 of these from Phase II HapMap data. • A higher density of tag SNPs in regions of the genome within 10kb of a gene or in evolutionarily conserved regions. • Approximately 7,300 nsSNPs (non-synonymous amino-acid changing SNPs). • A higher density of SNPs across Major Histocompatibility Complex (MHC) regions. • Higher genomic coverage with fewer SNPs compared to wholegenome genotyping strategies that use randomly selected SNPs. • Approximate 5kb median SNP spacing, providing unprecedented resolution for detecting chromosomal aberrations. • The ability to analyze matched (paired) samples for LOH and DNA copy number analysis applications. • Over 52,000 SNPs in reported copy number variant (CNV) regions1.
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