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| Status |
Public on Jan 29, 2008 |
| Title |
Differential expression of inflammatory and immune response genes in sheep infected with Anaplasma phagocytophilum. |
| Platform organisms |
Sus scrofa; Bos taurus; Ovis aries |
| Sample organism |
Ovis aries |
| Experiment type |
Expression profiling by array
|
| Summary |
Anaplasma phagocytophilum is the causative agent of tick-borne fever (TBF) in ruminants and human, equine and canine granulocytic anaplasmosis. A. phagocytophilum modifies host gene expression and immune response. The objective of this work was to analyze differential gene expression in A. phagocytophilum-infected sheep using microarray hybridization and real-time RT-PCR in experimentally and naturally infected animals.
Keywords: disease state analysis
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| Overall design |
one-month old lambs from an experimental flock without a known history of contact with ticks and tick-borne pathogens were weaned and left uninfected to serve as controls or infected with a pool of blood samples obtained from commercial flocks with a previous history of TBF, located in the Basque Country, Northern Spain.
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| Contributor(s) |
Patricia AJ |
| Citation(s) |
18640728 |
| |
| Submission date |
Jan 26, 2008 |
| Last update date |
Mar 19, 2012 |
| Contact name |
Patricia J Ayoubi |
| E-mail(s) |
ayoubi@okstate.edu
|
| Phone |
405-744-6209
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| Fax |
405-744-7799
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| URL |
http://microarray.okstate.edu
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| Organization name |
Oklahoma State University
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| Department |
Biochemistry and Molecular Biology
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| Lab |
OSU Microarray Core Facility
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| Street address |
246 NRC
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| City |
Stillwater |
| State/province |
OK |
| ZIP/Postal code |
74078 |
| Country |
USA |
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| Platforms (1) |
| GPL4456 |
OSU RIGUA (Ruminant Immuno-inflammatory Gene Universal Array) 4K |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA108493 |
