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Series GSE10450 Query DataSets for GSE10450
Status Public on Mar 30, 2009
Title Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer
Organism Mus musculus
Experiment type Expression profiling by array
Summary Elevated Met receptor tyrosine kinase (RTK) expression correlates with poor outcome in breast cancer, yet a causal role for Met in the development of breast cancer has not been directly established. To examine this question, we generated a transgenic mouse model that targets expression of an oncogenic Met receptor (MetMut) to the mammary epithelium. We show that MetMut induces mammary tumors with a variety of histopathologies that exhibit gene expression profiles sharing similarities with human basal and luminal breast tumor subtypes. Among all breast cancers, we further demonstrate that the Met receptor is primarily overexpressed in human basal and HER2 positive breast cancers, and that a Met associated gene expression signature identifies patients with poor prognosis.
Keywords: Met, mammary, poor outcome, EMT, basal breast cancer
 
Overall design Common reference design. 26 samples (including 20 normal tissue and 32 tumor tissue samples) replicated twice as dye swaps, generating a total of 52 arrays.
 
Contributor(s) Ponzo MG, Lesurf R, Petkiewicz S, O’Malley FP, Pinnaduwage D, Andrulis IL, Bull SB, Chughtai N, Zuo D, Souleimanova M, Germain D, Omeroglu A, Cardiff RD, Hallett M, Park M
Citation(s) 19617568
Submission date Feb 08, 2008
Last update date May 10, 2018
Contact name Robert Lesurf
Organization name Washington University in St. Louis
Department McDonnell Genome Institute
Lab Griffith Lab
Street address 4444 Forest Park Ave
City St. Louis
State/province MO
ZIP/Postal code 63112
Country USA
 
Platforms (2)
GPL2872 Agilent-012694 Whole Mouse Genome G4122A (Feature Number version)
GPL4134 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)
Samples (52)
GSM262223 562T.tumor.Cy3
GSM262224 562T.tumor.Cy5
GSM262225 4164N.normal.Cy5
Relations
BioProject PRJNA108003

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10450_RAW.tar 629.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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