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GEO help: Mouse over screen elements for information. |
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Status |
Public on Mar 30, 2009 |
Title |
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Elevated Met receptor tyrosine kinase (RTK) expression correlates with poor outcome in breast cancer, yet a causal role for Met in the development of breast cancer has not been directly established. To examine this question, we generated a transgenic mouse model that targets expression of an oncogenic Met receptor (MetMut) to the mammary epithelium. We show that MetMut induces mammary tumors with a variety of histopathologies that exhibit gene expression profiles sharing similarities with human basal and luminal breast tumor subtypes. Among all breast cancers, we further demonstrate that the Met receptor is primarily overexpressed in human basal and HER2 positive breast cancers, and that a Met associated gene expression signature identifies patients with poor prognosis. Keywords: Met, mammary, poor outcome, EMT, basal breast cancer
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Overall design |
Common reference design. 26 samples (including 20 normal tissue and 32 tumor tissue samples) replicated twice as dye swaps, generating a total of 52 arrays.
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Contributor(s) |
Ponzo MG, Lesurf R, Petkiewicz S, O’Malley FP, Pinnaduwage D, Andrulis IL, Bull SB, Chughtai N, Zuo D, Souleimanova M, Germain D, Omeroglu A, Cardiff RD, Hallett M, Park M |
Citation(s) |
19617568 |
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Submission date |
Feb 08, 2008 |
Last update date |
May 10, 2018 |
Contact name |
Robert Lesurf |
Organization name |
Washington University in St. Louis
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Department |
McDonnell Genome Institute
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Lab |
Griffith Lab
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Street address |
4444 Forest Park Ave
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City |
St. Louis |
State/province |
MO |
ZIP/Postal code |
63112 |
Country |
USA |
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Platforms (2) |
GPL2872 |
Agilent-012694 Whole Mouse Genome G4122A (Feature Number version) |
GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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Samples (52)
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Relations |
BioProject |
PRJNA108003 |
Supplementary file |
Size |
Download |
File type/resource |
GSE10450_RAW.tar |
629.2 Mb |
(http)(custom) |
TAR (of TXT) |
Processed data included within Sample table |
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