|
| Status |
Public on Oct 10, 2017 |
| Title |
Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the zinc transporter ZIP8 (SLC39A8) protein.
In this study, we have attempted to explore the effects of ZIP8 overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.
|
| |
|
| Overall design |
Primary mouse articular chondrocytes were isolated from mouse femoral condyles and tibial plateaus cartilage tissue (WT ICR 5-day-old mice) and were infected with null(control) or recombinant adenovirus expressing zinc transporter ZIP8 for 24 hours. At 24 hours post-infection, total RNA was extracted from infected with null(control) adenovirus (4 biological replicates) or infected with recombinant adenovirus expressing the zinc transporter ZIP8 (4 biological replicates) on primary mouse articular chondrocytes and subjected to microarray analysis.
|
| |
|
| Contributor(s) |
Chun J |
| Citation(s) |
26903440, 30622281, 30728500, 33853646, 33559324, 37259103, 38057865 |
| |
| Submission date |
Oct 10, 2017 |
| Last update date |
Dec 14, 2023 |
| Contact name |
Yoonkyung Won |
| E-mail(s) |
ykwon@gist.ac.kr
|
| Organization name |
Gwangju Institute of Science and Technology
|
| Street address |
123 Cheomdangwagiro
|
| City |
Gwangju |
| ZIP/Postal code |
61005 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (8)
|
| GSM2807985 |
Ad-null infected primary mouse articular chondrocytes, rep 1 |
| GSM2807986 |
Ad-null infected primary mouse articular chondrocytes, rep 2 |
| GSM2807987 |
Ad-null infected primary mouse articular chondrocytes, rep 3 |
| GSM2807988 |
Ad-null infected primary mouse articular chondrocytes, rep 4 |
| GSM2807989 |
Ad-Zip8 infected primary mouse articular chondrocytes, rep 1 |
| GSM2807990 |
Ad-Zip8 infected primary mouse articular chondrocytes, rep 2 |
| GSM2807991 |
Ad-Zip8 infected primary mouse articular chondrocytes, rep 3 |
| GSM2807992 |
Ad-Zip8 infected primary mouse articular chondrocytes, rep 4 |
|
| Relations |
| BioProject |
PRJNA413833 |
Less...
More...