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| Status |
Public on May 26, 2018 |
| Title |
Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [mouse gene expression] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis remains unknown. Here, we showed that B. wadsworthia synergize with HFD to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis unraveled pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by B. wadsworthia. Pharmacological suppression of B. wadsworthia-associated inflammation unmasked the bacterium’s intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Finally, the probiotic Lactobacillus rhamnosus CNCM I-3690 was able to limit B. wadsworthia-induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results support a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.
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| Overall design |
Microarray analysis was performed by using total tissue from caecum tip of mice on week 5 post-treatment.
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| Contributor(s) |
Natividad JM, Lamas B, Pham HP, Michel M, Rainteau D, Bridonneau C, da Costa G, Sovran B, Planchais J, Lavie-Richard M, Langella P, Veiga P, Sokol H |
| Citation(s) |
30022049 |
| Submission date |
Mar 06, 2018 |
| Last update date |
Aug 27, 2018 |
| Contact name |
Phuong Hang PHAM |
| E-mail(s) |
hp.pham@pareanbiotech.fr
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| Organization name |
Parean Biotechnologies
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| Department |
Data science
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| Lab |
Bat B, Lab 3
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| Street address |
7 allée Métis
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| City |
Saint-Malo |
| ZIP/Postal code |
35400 |
| Country |
France |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (27)
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| This SubSeries is part of SuperSeries: |
| GSE112388 |
Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners |
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| Relations |
| BioProject |
PRJNA437083 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE111451_RAW.tar |
355.2 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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