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| Status |
Public on Dec 31, 2018 |
| Title |
Comparison of microRNA expression profiling in pig spleens among three time points after infection by Chinese I genotype strain of Toxoplasma gondii |
| Organism |
Sus scrofa |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
The objectives of the present study were to analyze the changes on miRNA expression profile in swine spleen using next-generation sequencing (NGS) technology and bioinformatic analysis at 10, 25 and 50 days post inoculation (DPI) with Chinese I genotype strain of T. gondii. Compared to control group, 34, 6 and 86 differentially expressed miRNAs (DEMs) were respectively found in spleens of infected pigs at 10, 25 and 50 DPI. The results not only showed that the miRNA expression of the host can be changed by the invasion of T. gondii, but also revealed the differences on the regulation of the key biological processes or pathways involved in host responses between the acute and chronic T. gondii infection.
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| Overall design |
Differential expression of porcine microRNAs at three time points after infection with Chinese I genotype strain of Toxoplasma gondii were analyzed by deep sequencing
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| Contributor(s) |
Hou Z, Tao J |
| Citation(s) |
30700253, 35177094 |
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| Submission date |
Apr 13, 2018 |
| Last update date |
Mar 03, 2022 |
| Contact name |
Hou Zhaofeng |
| E-mail(s) |
hzf2006sj@163.com
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| Organization name |
Yangzhou University
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| Street address |
No. 12, Wenhui East Road
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| City |
Yangzhou |
| State/province |
Jiangsu |
| ZIP/Postal code |
225009 |
| Country |
China |
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| Platforms (1) |
| GPL19176 |
Illumina HiSeq 2500 (Sus scrofa) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA450089 |
| SRA |
SRP139950 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE113130_RAW.tar |
110.0 Kb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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