|
| Status |
Public on May 01, 2021 |
| Title |
Kdm6 inhibitor as leptin sensitizer in the hypothalamus of high fat diet induced obesity mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To further identify the mostly influenced signal pathways under Kdm6 inhibitor treatment, the microarray analysis was performed to screen the gene expression profile in the hypothalamus of DIO mice. The DIO mice were administrated with vehicle or 30 mg/kg GSK-J4 i.p. for 4 days. Totally, 205 genes were up regulated over 2 fold and 845 genes were down regulated over 2 fold.
|
| |
|
| Overall design |
GSK-J4 induced gene expression in mouse hypothalamus was measured at 4 d after exposure to doses of 0 and 30mg/kg. Three independent experiments were performed using different mouse for each experiment.
|
| |
|
| Contributor(s) |
Wang X, Wei Y |
| Citation(s) |
34306972 |
| |
| Submission date |
May 30, 2018 |
| Last update date |
Jul 28, 2021 |
| Contact name |
Xu Wang |
| E-mail(s) |
wangx312016@sh9hospital.org.cn
|
| Phone |
+86-021-23271699
|
| Organization name |
Shanghai Jiao Tong university, School of Medicine
|
| Street address |
No. 639, Zhizaoju Road
|
| City |
Shanghai |
| ZIP/Postal code |
200011 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA473819 |
Less...
More...