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Series GSE119275 Query DataSets for GSE119275
Status Public on Oct 31, 2018
Title Expression-based drug screening of neural progenitor cells from individuals with schizophrenia [MSA101]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Integration of in silico and in vitro approaches to design and conduct transcriptomic drug screening in patient-derived neural cells, in order to survey novel pathologies and points of intervention in schizophrenia.
 
Overall design Here we compare the transcriptional responses of eight commonly used cancer cell lines (CCLs) directly to that of human induced pluripotent stem cell (hiPSC)-derived neural progenitor cells (NPCs) from twelve individuals with SZ and twelve controls across 135 drugs, generating over 4,300 unique drug-response transcriptional signatures.
 
Contributor(s) Brennand KJ
Citation(s) 30356048
Submission date Aug 30, 2018
Last update date Dec 31, 2020
Contact name Ben Readhead
E-mail(s) ben.readhead@asu.edu
Organization name ASU-Banner Neurodegenerative Disease Research Center
Street address 797 E. Tyler Street
City Tempe
State/province AZ
ZIP/Postal code 85281
Country USA
 
Platforms (1)
GPL25480 Genometry L1000™ Expression Profiling
Samples (374)
GSM3363001 MSA101_A03_dihydroergocristine 1_uM 6_hours BJ-2-A
GSM3363002 MSA101_A05_Chlorpromazine 0.1_uM 6_hours BJ-2-A
GSM3363003 MSA101_A06_Chlorpromazine 0.1_uM 6_hours 2484-2-A
This SubSeries is part of SuperSeries:
GSE119291 Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
Relations
BioProject PRJNA488646

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary data files not provided
Processed data included within Sample table

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