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Series GSE120823 Query DataSets for GSE120823
Status Public on Oct 15, 2018
Title RNA-Seq of adult chicken sickle feather tissues between male and female
Organism Gallus gallus
Experiment type Expression profiling by high throughput sequencing
Summary Many animals can change their coats in response to different ages, sexes, or seasonal environmental changes. The hormones can also alter the size, shape, texture and color of the regenerated coat. Here we propose feather core branching morphogenesis module can be modulated by sex hormone or other environmental factors to change the form, texture or colors, thus generate a large spectrum of complexity for adaptation. We use sexual dimorphisms of the feather coat to explore the role of hormones in in coat morphogenesis and regeneration. A long-standing question is whether the sex-dependent feather morphologies are autonomously controlled by the male or female cell types, or extrinsically controlled and reversible. We have recently identified core feather branching molecular modules which control the anterior-posterior (BMP, Wnt gradient), medio-lateral (retinoic signaling, gremlin), and proximo-distal (sprouty, BMP) patterning of feathers. We hypothesize that modulatory signaling modules can be added upon these core branching modules to topologically tune the dimension of each parameter. Here we explore the involvement of hormones in generating sexual dimorphisms using exogenously delivered hormones. Our strategy is to mimic androgen levels by applying exogenous dihydrotestosterone and aromatase inhibitors to adult females and injecting exogenous estradiol to adult males. We also examine differentially expressed genes in the feathers of wildtype male and female chickens to identify potential downstream modifiers of feather morphogenesis. The data show male and female feather morphology and their color patterns can be modified extrinsically through molting and reseting the stem cell niche during regeneration.
 
Overall design Six kinds of adult chicken sickle feather tissues between male (M) and female (F), including lower follicle sheath (LFS), upper follicle sheath (UFS), pulp (PP), epithelium (EPi), papilla ectoderm (PE), and dermal papilla (DP)
 
Contributor(s) Widelitz RB, Chuong C
Citation(s) 30569461
Submission date Oct 04, 2018
Last update date Jan 03, 2019
Contact name Randall B. Widelitz
E-mail(s) widelitz@med.usc.edu
Organization name University of Southern California
Department Department of Pathology
Street address 2011 Zonal Ave HMR 305
City Los Angeles
State/province California
ZIP/Postal code 90033
Country USA
 
Platforms (1)
GPL19787 Illumina NextSeq 500 (Gallus gallus)
Samples (24)
GSM3416411 M_LFS_R394
GSM3416412 M_UFS_R395
GSM3416413 M_PP_R396
Relations
BioProject PRJNA494645
SRA SRP163400

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE120823_RAW.tar 1.9 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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