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| Status |
Public on Nov 09, 2018 |
| Title |
The transcriptomic profile of porcine anterior pituitary cells is influenced by adiponectin |
| Platform organism |
Sus scrofa |
| Sample organism |
Sus scrofa domesticus |
| Experiment type |
Expression profiling by array
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| Summary |
Adiponectin is thought to be involved in the regulation of metabolic homeostasis and reproductive processes. Adiponectin controls carbohydrate and lipid metabolism by regulating the fatty acid oxidation process, increasing insulin sensitivity and decreasing plasma triglyceride levels. Adiponectin also plays an important role in the modulation of female reproductive functions, both directly and by influencing the secretory functions of the higher branches of the hypothalamic-pituitary-gonadal axis. The main aim of this study was to determine the effect of adiponectin on global gene expression and on differentially expressed genes (DE-genes) under the influence of the studied hormone in porcine anterior pituitary (AP) cells.
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| Overall design |
We analyzed samples obtained from 4 individuals (n=4). Obtained from the anterior pituitary culture cells were divided for two groups: controls [without treatment] and adiponectin treated ones. The concentration of adiponectin in the culture medium was 10 μg/ml. In vitro cells cultures were cultivated with treatments for 24 hours.
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| Contributor(s) |
Szeszko K, Smolinska N, Kiezun M, Dobrzyn K, Rytelewska E, Kisielewska K, Gudelska M, Kaminski T |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 08, 2018 |
| Last update date |
Nov 10, 2018 |
| Contact name |
Kamil Dobrzyn |
| E-mail(s) |
kamil.dobrzyn@uwm.edu.pl
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| Organization name |
University of Warmia and Mazury
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| Department |
Department of Animal Anatomy and Physiology
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| Lab |
Faculty of Biology and Biotechnology
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| Street address |
Oczapowskiego, 1A
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| City |
Olsztyn |
| State/province |
Warminsko-Mazurskie |
| ZIP/Postal code |
10 719 |
| Country |
Poland |
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| Platforms (1) |
| GPL16571 |
Agilent-026440 Sus scrofa (Pig) Oligo Microarray v2 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA504627 |
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