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| Status |
Public on Nov 14, 2018 |
| Title |
The in vitro influence of orexin B on the porcine endometrium on days 15 to 16 of gestation. |
| Platform organism |
Sus scrofa |
| Sample organism |
Sus scrofa domesticus |
| Experiment type |
Expression profiling by array
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| Summary |
Orexins, namely orexin A (OXA) and orexin B (OXB) belongs to the family of neuropeptides produced mainly by specific neurons of the lateral region of the hypothalamus. Primarily orexins were recognized as hormones involved exclusively in the regulation of food intake and energy homeostasis. However, a growing body of evidences indicate their involvement in the regulation of an increasing number of biological processes, inter alia, in the regulation of the reproductive functions. The aim of this study was to explore the influence of orexin B on global gene expression in the porcine endometrium during early gestation, on days 15 to 16 of pregnancy (implantation period).
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| Overall design |
We analized samples obtained from 4 indyviduals (n=4). Obtained from the uterine horns tissue explants were divided for two groups: controls [without treatment] and orexin B treated grous. The concentration of orexin B in the culture medium was 10 nM. In vitro tissue cultures were cultivated with treatments for 24 hours.
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| Contributor(s) |
Dobrzyn K, Szeszko K, Kiezun M, Rytelewska E, Kisielewska K, Gudelska M, Kaminski T, Smolinska N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 11, 2018 |
| Last update date |
Nov 15, 2018 |
| Contact name |
Kamil Dobrzyn |
| E-mail(s) |
kamil.dobrzyn@uwm.edu.pl
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| Organization name |
University of Warmia and Mazury
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| Department |
Department of Animal Anatomy and Physiology
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| Lab |
Faculty of Biology and Biotechnology
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| Street address |
Oczapowskiego, 1A
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| City |
Olsztyn |
| State/province |
Warminsko-Mazurskie |
| ZIP/Postal code |
10 719 |
| Country |
Poland |
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| Platforms (1) |
| GPL16571 |
Agilent-026440 Sus scrofa (Pig) Oligo Microarray v2 (Probe Name version) |
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| Samples (4)
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| GSM3466338 |
endometrium OXB treated vs non-treated 1 |
| GSM3466339 |
endometrium OXB treated vs non-treated 2 |
| GSM3466340 |
endometrium OXB treated vs non-treated 3 |
| GSM3466341 |
endometrium OXB treated vs non-treated 4 |
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| Relations |
| BioProject |
PRJNA505073 |
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