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| Status |
Public on Jan 17, 2022 |
| Title |
Transcriptomic profile of YB-1 regulated downstream targets in LNCaP prostate cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The transcription factor and RNA-interacting Y-box binding protein-1 (YB-1 protein, YBX1 gene) has gained interest as a prognostic biomarker and therapeutic target in various malignancies including prostate cancer. Using a custom prostate-cancer-focussed microarray platform, we have established a transcriptome-wide profile of YB-1 target transcripts in the androgen sensitive prostate cancer cell line LNCaP, including RNAs regulated by YB-1 at the transcriptional and post-transcriptional level; under standard culture conditions (FBS), in androgen deprived culture conditions (CSS) and following stimulation with dihydrotestosterone (DHT).
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
The project consists of 3 data sets / SubSeries that were processed and analysed separately. Each data set was derived from 3-4 independent biological repeats for each sample group.
Refer to individual Series
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| Contributor(s) |
Rockstroh A, Pokorny MR, Walker C, Lehman ML, McPherson S, Nelson CC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 18, 2019 |
| Last update date |
Jul 17, 2024 |
| Contact name |
Colleen Nelson |
| Organization name |
Queensland University of Technology; University of British Columbia
|
| Department |
Institute of Health and Biomedical Innovation; Vancouver Prostate Centre
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| Street address |
199 Ipswich Road
|
| City |
Brisbane |
| State/province |
Queensland |
| ZIP/Postal code |
4102 |
| Country |
Australia |
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| Platforms (1) |
| GPL25684 |
Agilent-032034 VPC Human 180K v3 (Ensembl 77 / Gencode 21 / GRCh38 annotation) |
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| Samples (37)
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| This SuperSeries is composed of the following SubSeries: |
| GSE125337 |
YB-1 RIP.chip - Co-immunoprecipitation of RNAs present in YB-1 containing RNP granules in LNCaP cells in FBS, CSS and DHT culture |
| GSE125338 |
Transcriptome changes upon androgen deprivation and DHT stimulation in LNCaP cells |
| GSE125339 |
YB-1 knock.down - siRNA driven YBX1 knock.down in LNCaP cells in std FBS culture |
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| Relations |
| BioProject |
PRJNA515890 |
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