|
| Status |
Public on May 10, 2019 |
| Title |
Inhibition of gene transcription after THZ1 treatment in HeLa |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To explore the transcriptional inhibition of the CDK7 inhibitor THZ1 in cervical cancer cells, we used gene expression miceoarray analysis to detect the gene expression profiles after THZ1 treatment in HeLa compared with negative control（DMSO）. HeLa was trreated with 100 nM THZ1 or DMSO, and total RNA was extracted after treatment for 6 hours. Microarray analysis showed that massive oncogene transcripts, especially those associated with tumorigenesis, were preferential suppressed after THZ1 treatment.
|
| |
|
| Overall design |
HeLa was treated with treatment with THZ1 or DMSO, and then total RNA was extracted using TRIZOL after treatment for 6 hours. Each group has three replicates.
|
| |
|
| Contributor(s) |
Zhong S, Zhang Y, Yin X, Di W |
| Citation(s) |
30962695 |
| |
| Submission date |
Jan 23, 2019 |
| Last update date |
May 10, 2019 |
| Contact name |
Shanshan Zhong |
| E-mail(s) |
zhongshanshan1128@163.com
|
| Phone |
8617521199484
|
| Organization name |
Ren Ji hospital
|
| Street address |
NO.160 Road, Pudong New District
|
| City |
Shanghai |
| ZIP/Postal code |
200127 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL21185 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Probe Name Version] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA516711 |
Less...
More...