|
| Status |
Public on Oct 22, 2008 |
| Title |
Genotyping data from 54 patients with deficit schizophrenia |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Schizophrenia is a severe psychiatric disease with complex etiology, affecting approximately one percent of the general population. Most genetic studies so far focused on disease association with common genetic variation such as single nucleotide polymorphisms, but recently it has become apparent that large-scale genomic copy number variants (CNVs) are involved in disease development as well.
To assess the role of rare CNVs in schizophrenia, we screened 54 patients with deficit schizophrenia using Affymetrix’ GeneChip 250K SNP arrays.
Keywords: genomic hybridisation
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| |
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| Overall design |
We hybridized genomic DNA of 54 patients with deficit schizophrenia to Affymetrix' GeneChip 250K SNP (Nsp) arrays, and identified genome-wide CNV using the Copy Number Analyzer for Affymetrix GeneChip (CNAG v2.0) software, which uses a Hidden Markov Model (HMM) algorithm to calculate copy numbers.
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| |
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| Contributor(s) |
Veltman J, Hehir-Kwa J |
| Citation(s) |
18940311 |
| |
| Submission date |
Sep 09, 2008 |
| Last update date |
May 17, 2017 |
| Contact name |
Joris Andre Veltman |
| E-mail(s) |
j.veltman@gen.umcn.nl
|
| Phone |
+31 24 3614941
|
| Fax |
+31 24 3668752
|
| URL |
http://www.umcn.nl/Research/Departments/HumanGenetics/Pages/default.aspx
|
| Organization name |
Radboud University Nijmegen Medical Centre
|
| Department |
Human Genetics
|
| Lab |
Genomic Disorders
|
| Street address |
Geert Grooteplein 10
|
| City |
Nijmegen |
| ZIP/Postal code |
6500HB |
| Country |
Netherlands |
| |
|
| Platforms (1) |
| GPL3718 |
[Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array |
|
| Samples (54)
|
|
| Relations |
| BioProject |
PRJNA112649 |
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