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| Status |
Public on Sep 15, 2020 |
| Title |
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Disturbance of heterologous cell communication is associated with a structural reorganization of the vascular niche, a process called capillarization, which is already initiated in early stages of liver tumor development. In this study, the molecular characterization of endothelial cell (EC) subpopulations from healthy livers and yes-associated protein (Yap)-induced liver tumors revealed a dynamic crosstalk between liver sinusoidal endothelial cells (LSECs) and capillary endothelial cells (CECs). Initial paracrine stimuli from parenchymal cells include the Yap/Tead4 target gene osteopontin (Opn), which promotes CECs expansion through the induction of c-Met and sensitization towards LSEC-derived hepatocyte growth factor (Hgf). In addition, Yap/Tead4-induced C-C motif chemokine ligand 2 (Ccl2) recruits bone-marrow-derived macrophages (BMDMs) with an unpolarized phenotype (M0) to the perivascular space of expanding CECs.
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| Overall design |
10 samples in total: 3 unstimulated, 4 samples 3 hours after HGF stimulation, 3 samples 6 h after HGF stimulation.
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| Contributor(s) |
Thomann S, Breuhahn K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 08, 2019 |
| Last update date |
Sep 17, 2020 |
| Contact name |
Carsten Sticht |
| Organization name |
University Heidelberg
|
| Department |
ZMF
|
| Street address |
Theodor-Kutzer-Ufer
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| City |
Mannheim |
| ZIP/Postal code |
68169 |
| Country |
Germany |
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| Platforms (1) |
| GPL23092 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array (mogene20st_Mm_ENTREZG_21.0.0) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE128047 |
An endothelial subtype-specific communication network orchestrates capillarization in liver tumorigenesis via the Hgf/c-Met pathway |
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| Relations |
| BioProject |
PRJNA526203 |
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