|
| Status |
Public on Feb 01, 2010 |
| Title |
Expression of Cdx2 or Gata3 in R1 mouse embryonic stem cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify whether Cdx2 or Gata3 can activate trophoblast specific gene expression when expressed in R1 ES cells. To assess the dependency of Gata3 activity on Cdx2, Gata3 was also expressed in Cdx2-null ES cells.
Keywords: gene expression
|
| |
|
| Overall design |
a fusion construct of either Cdx2 or Gata3 and the tamoxifen responsive estrogen receptor ligand binding domain was expressed in R1 ES cells. Cell were induced with tamoxifen for 6 days to activate the transcription factor and cultured under trophoblast stem cell conditions
|
| |
|
| Contributor(s) |
Cox B, Ralston A, Rossant J |
| Citation(s) |
20081188 |
| |
| Submission date |
Sep 30, 2008 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Brian Joseph Cox |
| E-mail(s) |
b.cox@utoronto.ca
|
| Organization name |
University of Toronto
|
| Department |
Physiology
|
| Lab |
Cox System Biology
|
| Street address |
1 King's College Circle, Rm 3360
|
| City |
Toronto |
| State/province |
Ontario |
| ZIP/Postal code |
M5S1A8 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (10)
|
|
| This SubSeries is part of SuperSeries: |
| GSE12999 |
Gata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development |
|
| Relations |
| BioProject |
PRJNA114249 |
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