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| Status |
Public on Jan 01, 2020 |
| Title |
RNA-Seq analysis of gene expression in 25 cases of canine lymphoma undergoing CHOP chemotherapy |
| Organism |
Canis lupus familiaris |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Canine lymphoma is the most common hematological cancer in dogs and shares many molecular and clinical characteristics with human Non-Hodgkin lymphoma (NHL). The standard treatment for canine lymphoma is the “CHOP” sequential multiagent chemotherapy protocol consisting of Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Vincristine (Oncovin™), and Prednisone. Approximately 70 - 85% of patients treated with CHOP achieve clinical remission. However, duration of remission varies and the majority of dogs eventually relapse. To identify possible biomarkers for patients failing to achieve remission in response to CHOP, we performed RNA-Seq analysis on 25 cases of canine lymphoma taken at the start of their CHOP therapy regime, and determined patient progression free survival (PFS).
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| Overall design |
Tumor samples from 25 dogs with lymphoma. Samples were collected prior to treatment with CHOP. There were no replicate or control samples.
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| Contributor(s) |
Mee M, Coomber B |
| Citation(s) |
35317846 |
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| Submission date |
May 08, 2019 |
| Last update date |
Mar 31, 2022 |
| Contact name |
Miles Mee |
| E-mail(s) |
miles.william.mee@gmail.com
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| Organization name |
Ontario Institute for Cancer Research
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| Street address |
661 University Ave Suite 510
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| City |
Toronto |
| ZIP/Postal code |
M5G 0A3 |
| Country |
Canada |
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| Platforms (1) |
| GPL22370 |
Illumina MiSeq (Canis lupus familiaris) |
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| Samples (25)
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| GSM3755498 |
Lymphoma, long, 005_S5 |
| GSM3755499 |
Lymphoma, long, 006_S6 |
| GSM3755500 |
Lymphoma, long, 008_S7 |
| GSM3755501 |
Lymphoma, short, 009_S8 |
| GSM3755502 |
Lymphoma, long, 012_S9 |
| GSM3755503 |
Lymphoma, long, 016_S10 |
| GSM3755504 |
Lymphoma, long, 017_S11 |
| GSM3755505 |
Lymphoma, long, 022_S12 |
| GSM3755506 |
Lymphoma, short, 024A_S13 |
| GSM3755507 |
Lymphoma, long, 025A_S15 |
| GSM3755508 |
Lymphoma, long, 026A_S17 |
| GSM3755509 |
Lymphoma, short, 027A_S19 |
| GSM3755510 |
Lymphoma, short, 028A_S21 |
| GSM3755511 |
Lymphoma, short, 029A_S23 |
| GSM3755512 |
Lymphoma, short, 030A_S25 |
| GSM3755513 |
Lymphoma, long, 031A_S27 |
| GSM3755514 |
Lymphoma, long, 033A_S29 |
| GSM3755515 |
Lymphoma, long, 034A_S31 |
| GSM3755516 |
Lymphoma, short, 035A_S33 |
| GSM3755517 |
Lymphoma, long, 036A_S35 |
| GSM3755518 |
Lymphoma, long, 037A_S37 |
| GSM3755519 |
Lymphoma, long, 038A_S39 |
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| Relations |
| BioProject |
PRJNA541858 |
| SRA |
SRP197055 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE130874_FPKM_matrix.tsv.gz |
3.0 Mb |
(ftp)(http) |
TSV |
| GSE130874_read_count_matrix.tsv.gz |
1009.7 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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