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Series GSE13440 Query DataSets for GSE13440
Status Public on Aug 05, 2009
Title Transcriptome patterns for Acute Cellular Rejection in Recipients with Recurrent Hepatitis C after Liver Transplantation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The histological evaluation of liver via biopsy remains as the standard for the diagnosis of both acute cellular rejection (ACR) and recurrent hepatitis C (RHC) after liver transplantation. Nevertheless, it is often difficult to diagnose ACR in HCV-positive recipients because of common co-existing and overlapping morphological changes with RHC. The aim of the study was to identify potential target genes for ACR in recipients with RHC. We analyzed 22 liver biopsy samples obtained from 21 HCV-positive recipients. The clinicopathological diagnoses for the biopsies were ACR-predominant with superimposed RHC in 9 samples (ACR group) and RHC with no ACR (non-ACR group) in the remaining. We compared the transcriptional alterations between the two groups with oligonucleotide microarray and selected 2206 genes which were significantly modulated in ACR. Subsequently we analyzed the regulatory networks in ACR using Ingenuity Pathway Analysis, and focused on 5 genes (IFNAR1, IL-12RB2, NFATC3, BMP2, and CASP8) from the core network as the target genes for ACR. In conclusion, our results demonstrated that novel transcriptome patterns of ACR and concurrent RHC were present and distinct from recipients with only RHC, suggesting that gene expression profiling may have a role in the diagnosis of ACR in recipients with hepatitis C.

Keywords: Gene identification in ACR with recurrent HCV infection
 
Overall design Of 22 liver biopsy samples, 9 represented the clinicopathological diagnoses for ACR-predominant with superimposed RHC (ACR group) and 13 represented the clinicopathological diagnoses for RHC with no ACR (non-ACR group) .
 
Citation(s) 19938108
Submission date Nov 03, 2008
Last update date Mar 20, 2012
Contact name Tadafumi Asaoka
E-mail(s) tasaoka@gesurg.med.osaka-u.ac.jp
Phone +81-6-6879-3251
Fax +81-6-6879-3259
Organization name Osaka University
Department Surgery
Street address 2-2, Yamadaoka
City Suita
ZIP/Postal code 565-0871
Country Japan
 
Platforms (1)
GPL1291 Hitachisoft AceGene Human Oligo Chip 30K 1 Chip Version
Samples (22)
GSM339241 Recipient 1 diagnosed as ACR-predominant with superimposed RHC
GSM339242 Recipient 2 diagnosed as ACR-predominant with superimposed RHC
GSM339243 Recipient 3 diagnosed as ACR-predominant with superimposed RHC
Relations
BioProject PRJNA110033

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE13440_RAW.tar 126.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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