|
| Status |
Public on Jan 23, 2020 |
| Title |
Time-driven molding of the epidermal stem cell transcriptome |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Epidermal stem cells ensure proper faring of skin homeostatic processes under both physiological and challenging conditions. Currently, the molecular events underpinning ageing within the epidermal stem cell niche are poorly understood.
Here, we report that epidermal stem cells are endowed with a collection of time-sensitive genes which constitute specific functional programs that become deregulated in an age-dependent manner.
|
| |
|
| Overall design |
Epidermal stem cells (CD34+;Itga6+) from dorsal skin of 0.6-, 1-, 2.5-, 4-, 6- and 12-month-old mice (n = 3 per time point)
|
| |
|
| Contributor(s) |
Lorenzo-Martín LF, Bustelo XR |
| Citation(s) |
31936599, 37822868 |
| |
| Submission date |
Sep 10, 2019 |
| Last update date |
Oct 24, 2023 |
| Contact name |
L. Francisco Lorenzo-Martín |
| E-mail(s) |
luis.lorenzomartin@epfl.ch
|
| Organization name |
École Polytechnique Fédérale de Lausanne (EPFL)
|
| Lab |
Laboratory of Stem Cell Bioengineering
|
| Street address |
EPFL – SV – IBI – LSCB – Station 15
|
| City |
Lausanne |
| State/province |
Vaud |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA564747 |
Less...
More...