|
| Status |
Public on Sep 17, 2019 |
| Title |
Dissecting the dynamics of signaling events in the BMP,WNT and NODAL cascade during self-organized fate patterning in human gastruloids |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To determine the in vivo cellular identity of BMP-treated human embryonic stem cells (hESCs), we performed bulk RNA sequencing data of hESCs under pluripotency and BMP-treated conditions. Our analyses show that BMP-treated hESCs resemble human trophoblast cells in vivo.
|
| |
|
| Overall design |
mRNA profiles of four different samples, each with two biological replicates. Samples: 1) hESCs in mTeSR1 for 48h, 2) hESCs in mTeSR1+BMP4 for 48h, 3) hESCs in mTeSR1+BMP4+IWP2 for 48h, 4) hESCs in mTeSR1+BMP4+SB for 48h
|
| |
|
| Contributor(s) |
Chhabra S, Liu L, Goh R, Kong X, Warmflash A |
| Citation(s) |
31613879 |
| |
| Submission date |
Sep 16, 2019 |
| Last update date |
Nov 12, 2019 |
| Contact name |
Aryeh Warmflash |
| E-mail(s) |
aw21@rice.edu
|
| Phone |
7133482456
|
| Organization name |
Rice University
|
| Street address |
6100 Main St
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77005 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA565722 |
| SRA |
SRP221734 |
Less...
More...