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| Status |
Public on Jan 19, 2022 |
| Title |
Transcriptome-wide expression analysis of pooled brain samples of patients with Alzheimer's disease compared to controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by genome tiling array
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| Summary |
Brain tissue of 3 patients with Alzheimer's disease (AD) and 3 healthy controls dying without any history of neurological or psychiatric illness was used. The diagnosis of AD was made on the basis of both clinical and neuropathological evidence according to the criteria of the International Working Group (IWG) for New Research Criteria for the diagnosis of AD in the revision of 2014 (IWG-2),16 the NIA-AA diagnostic criteria in the revision of 201117 and the NIA-AA guidelines for the neuropathological assessment of AD. Only cases with typical AD according to IWG-2 criteria were included.
Transcriptome-wide expression of AD and healthy control samples was assessed with Affymetrix Human Whole Genome Tiling Array 1.0 Set.
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| Overall design |
Equal masses of total RNA derived from three patients with Alzheimer's disease and three control samples, respectively, were pooled. For each pool the Affymetrix Human Whole Genome Tiling Array 1.0 Set consisting of 14 arrays was used to assess transcriptome-wide expression.
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| Contributor(s) |
Arendt T, Arnold C, Hackermüller J, Horn F, Reiche K, Stadler PF, Ueberham U |
| Citation(s) |
32203153 |
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| Submission date |
Sep 30, 2019 |
| Last update date |
Jan 20, 2022 |
| Contact name |
Kristin Reiche |
| E-mail(s) |
kristin.reiche@izi.fraunhofer.de
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| Organization name |
Fraunhofer Institute for Cell Therapy and Immunology
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| Department |
Diagnostics
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| Street address |
Perlickstr. 1
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| City |
Leipzig |
| ZIP/Postal code |
04103 |
| Country |
Germany |
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| Platforms (14)
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| GPL6156 |
[Hs35b_M01R] Affymetrix Human Tiling 1.0R Set, Array 1 |
| GPL6157 |
[Hs35b_M02R] Affymetrix Human Tiling 1.0R Set, Array 2 |
| GPL6158 |
[Hs35b_M03R] Affymetrix Human Tiling 1.0R Set, Array 3 |
| GPL6159 |
[Hs35b_M04R] Affymetrix Human Tiling 1.0R Set, Array 4 |
| GPL6160 |
[Hs35b_M05R] Affymetrix Human Tiling 1.0R Set, Array 5 |
| GPL6161 |
[Hs35b_M06R] Affymetrix Human Tiling 1.0R Set, Array 6 |
| GPL6162 |
[Hs35b_M07R] Affymetrix Human Tiling 1.0R Set, Array 7 |
| GPL6163 |
[Hs35b_M08R] Affymetrix Human Tiling 1.0R Set, Array 8 |
| GPL6164 |
[Hs35b_M09R] Affymetrix Human Tiling 1.0R Set, Array 9 |
| GPL6165 |
[Hs35b_M10R] Affymetrix Human Tiling 1.0R Set, Array 10 |
| GPL6166 |
[Hs35b_M11R] Affymetrix Human Tiling 1.0R Set, Array 11 |
| GPL6167 |
[Hs35b_M12R] Affymetrix Human Tiling 1.0R Set, Array 12 |
| GPL6168 |
[Hs35b_M13R] Affymetrix Human Tiling 1.0R Set, Array 13 |
| GPL6169 |
[Hs35b_M14R] Affymetrix Human Tiling 1.0R Set, Array 14 |
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| Samples (28)
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| GSM4102027 |
Brain, AD_TilingArray_M04 |
| GSM4102028 |
Brain, AD_TilingArray_M05 |
| GSM4102029 |
Brain, AD_TilingArray_M06 |
| GSM4102030 |
Brain, AD_TilingArray_M07 |
| GSM4102031 |
Brain, AD_TilingArray_M08 |
| GSM4102032 |
Brain, AD_TilingArray_M09 |
| GSM4102033 |
Brain, AD_TilingArray_M10 |
| GSM4102034 |
Brain, AD_TilingArray_M11 |
| GSM4102035 |
Brain, AD_TilingArray_M12 |
| GSM4102036 |
Brain, AD_TilingArray_M13 |
| GSM4102037 |
Brain, AD_TilingArray_M14 |
| GSM4102038 |
Brain, Control_TilingArray_M01 |
| GSM4102039 |
Brain, Control_TilingArray_M02 |
| GSM4102040 |
Brain, Control_TilingArray_M03 |
| GSM4102041 |
Brain, Control_TilingArray_M04 |
| GSM4102042 |
Brain, Control_TilingArray_M05 |
| GSM4102043 |
Brain, Control_TilingArray_M06 |
| GSM4102044 |
Brain, Control_TilingArray_M07 |
| GSM4102045 |
Brain, Control_TilingArray_M08 |
| GSM4102046 |
Brain, Control_TilingArray_M09 |
| GSM4102047 |
Brain, Control_TilingArray_M10 |
| GSM4102048 |
Brain, Control_TilingArray_M11 |
| GSM4102049 |
Brain, Control_TilingArray_M12 |
| GSM4102050 |
Brain, Control_TilingArray_M13 |
| GSM4102051 |
Brain, Control_TilingArray_M14 |
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| This SubSeries is part of SuperSeries: |
| GSE138261 |
Alzheimer-related genes show accelerated evolution |
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| Relations |
| BioProject |
PRJNA575194 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE138214_RAW.tar |
611.9 Mb |
(http)(custom) |
TAR (of BED, CEL) |
| GSE138214_Ueberham_AD_K_highdiff3.bed.gz |
28.8 Kb |
(ftp)(http) |
BED |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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