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Status |
Public on Apr 20, 2020 |
Title |
Expression data of J3T-1, J3T-2, J3T-1shA, J3T-2A glioma |
Organism |
Canis lupus familiaris |
Experiment type |
Expression profiling by array
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Summary |
We have previously established two sibling glioma subclones, J3T-1 and J3T-2, showing distinct invasive and angiogenic phenotypes. J3T-1, expressing high annexin A2, demonstrates robust angiogenesis and tumor invasion around neovasculature. J3T-2, expressing low annexin A2, demonstrates diffuse invasion along white matter tracts. Knockdown of annexin A2 in J3T-1 (J3T-1shA) resulted in diffuse invasion pattern, and overexpression of annexin A2 in J3T-2 (J3T-2A) showed prominent angiogenesis. We used microarrays to identify genes which promote the phenotypic transition regulated by annexin A2.
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Overall design |
Total RNA of J3T-1, J3T-2, J3T-1shA, and J3T2A were isolated, and each gene expression profile was investigated using Affymetrix Canine Genome 2.0 Array.
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Contributor(s) |
Ichikawa T, Inoue S, Onishi M, Otani Y, Matsumoto Y |
Citation(s) |
32248843 |
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Submission date |
Oct 03, 2019 |
Last update date |
Apr 20, 2020 |
Contact name |
Yuji Matsumoto |
Organization name |
Okayama University
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Department |
Neurological Surgery
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Street address |
2-5-1 Shikata, kita-ku
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City |
Okayama |
ZIP/Postal code |
7008558 |
Country |
Japan |
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Platforms (1) |
GPL3738 |
[Canine_2] Affymetrix Canine Genome 2.0 Array |
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Samples (4)
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Relations |
BioProject |
PRJNA575655 |
Supplementary file |
Size |
Download |
File type/resource |
GSE138374_RAW.tar |
13.2 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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