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Series GSE138374 Query DataSets for GSE138374
Status Public on Apr 20, 2020
Title Expression data of J3T-1, J3T-2, J3T-1shA, J3T-2A glioma
Organism Canis lupus familiaris
Experiment type Expression profiling by array
Summary We have previously established two sibling glioma subclones, J3T-1 and J3T-2, showing distinct invasive and angiogenic phenotypes. J3T-1, expressing high annexin A2, demonstrates robust angiogenesis and tumor invasion around neovasculature. J3T-2, expressing low annexin A2, demonstrates diffuse invasion along white matter tracts. Knockdown of annexin A2 in J3T-1 (J3T-1shA) resulted in diffuse invasion pattern, and overexpression of annexin A2 in J3T-2 (J3T-2A) showed prominent angiogenesis.
We used microarrays to identify genes which promote the phenotypic transition regulated by annexin A2.
 
Overall design Total RNA of J3T-1, J3T-2, J3T-1shA, and J3T2A were isolated, and each gene expression profile was investigated using Affymetrix Canine Genome 2.0 Array.
 
Contributor(s) Ichikawa T, Inoue S, Onishi M, Otani Y, Matsumoto Y
Citation(s) 32248843
Submission date Oct 03, 2019
Last update date Apr 20, 2020
Contact name Yuji Matsumoto
Organization name Okayama University
Department Neurological Surgery
Street address 2-5-1 Shikata, kita-ku
City Okayama
ZIP/Postal code 7008558
Country Japan
 
Platforms (1)
GPL3738 [Canine_2] Affymetrix Canine Genome 2.0 Array
Samples (4)
GSM4106194 J3T1
GSM4106195 J3T2
GSM4106196 J3T1shA
Relations
BioProject PRJNA575655

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138374_RAW.tar 13.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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