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| Status |
Public on Oct 12, 2019 |
| Title |
Expression data from murine gut and spleen tissues |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TIM-1 is a gene that regulates immune responses including transplantation tolerence, allergy and asthma, autoimmunity, viral infections as well as cancer, however its role in transplantation has not been evaluated. Here we use a murine model of graft versus host disease (GVHD) to evaluate the therapeutic potential of blocking TIM-1 using an antibody.
We used microarray data to look for difference in gene expession in the gut which is one of the main organs that are afffected by GVHD as well as the spleen an organ when the immune response is generated. This will give us evidence as to whether the blocking TIM-1 mAb may modulate the immune response and protects against GVHD and promoted a less proinflammatory immune response
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| Overall design |
Gut and spleen tissue was collected on day 9 post transplantation for RNA extraction and hybridization on Affymetrix microarray. The mice received anti-TIM-1 mAb (3D10) a day prior to bone marrow transplantation (BMT) and then on day 3, 7, 11,17 post BMT
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| Contributor(s) |
Yang Y |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 11, 2019 |
| Last update date |
Oct 14, 2019 |
| Contact name |
Panagiota Iliopoulou |
| E-mail(s) |
ilio@stanford.edu
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| Phone |
(650)723 5544
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| Organization name |
Stanford University
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| Street address |
269 Campus Dr.
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94070 |
| Country |
USA |
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| Platforms (2) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA577126 |
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