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| Status |
Public on Oct 20, 2020 |
| Title |
Expression data from different expressed genes(DEGs) in human esophageal squamous cell carcinoma(ESCC) EC109 cells transfected with empty lentiviral vector(Lv-NC) or lentiviral vector carrying MEG3(Lv-MEG3) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Maternally expressed gene 3 (MEG3), a member of lncRNAs, has tumor-suppressor properties and is downregulated in the majority of malignancies. MEG3 was found to suppress some sorts of tumors through regulating epithelial mesenchymal transformation,inducing cell cycle arrest,triggering apoptosis and so on.
We used microarrays to investigate the possible regulatory mechanism of MEG3 in ESCC cell line.
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| Overall design |
MEG3 was overexpressed with lentivirus.Hence,EC109 cells harvested from three dishes were divided into two groups: Lv-NC(control group, Control) and Lv-MEG3 (overexpressing MEG3 group, MEG3).A DNA microarray was applied to analyze DEGs,accompanied by bioinformatics analyses including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway.
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| Contributor(s) |
Wu L, Li M |
| Citation(s) |
32901893 |
| |
| Submission date |
Dec 13, 2019 |
| Last update date |
Oct 20, 2020 |
| Contact name |
Li Ming kai |
| E-mail(s) |
limingkai27@126.com
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| Phone |
13794121482
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| Organization name |
Shantou University
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| Street address |
Dong Xia
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| City |
Shantou |
| ZIP/Postal code |
515041 |
| Country |
China |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA595609 |
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